bachelor's at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1992), master's at General Biology from Universidade Estadual de Campinas (1994) and doctorate at Biochemistry from Universidade Estadual de Campinas (1998). Has experience in Pharmacy, focusing on Pharmacy, acting on the following subjects: cultura de células, matriz extracelular, melanoma, crescimento tumoral and invasion and metastasis. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Piel de laboratorio |
| Laboratory Skin |
| Recreated skin |
| More itemsLess items |
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Chronic wounds affect a significant portion of the global population, particularly older adults with underlying health complications such as diabetes. The complex pathophysiology of chronic wounds involves persistent inflammation, reduced growth factor expression, and potential bacterial biofilm formation. Current treatment options lack specificity and face challenges posed by antimicrobi…
When diagnosed early, cutaneous melanoma is a curable neoplasm, but it is associated with a worse evolution in advanced disease. Melanoma lesions in sun-exposed sites and associated with a high mutational load and aberrant epigenetic regulation contribute to the development and progression of the disease. This is the type of skin cancer with the highest metastatic potential, which leads t…
(Only some records are available in English at this moment)
Melanoma is considered the most aggressive type of skin cancer and the one with the worst prognosis because of its high metastatic and proliferative capacity. Its carcinogenic process is related to the emergence of mutations on somatic genes related to cell cycle control, especially the MAPK pathway, in which BRAFV600E is the most frequent mutation. The development of immunotherapy and ta…
Melanoma is the most lethal type of skin cancer, characterized by its high metastatic potential. The MAPK pathway, frequently activated by mutations in BRAF(V600E), plays a central role in its pathogenesis. Despite significant progress with BRAF inhibitors and immunotherapies, treatment resistance amplified by intra-tumoral heterogeneity underscores the urgent need for new biomarkers and …
Melanogenesis is a complex and multifactorial process that is determinant for the safety of the skin against solar radiation. Inside melanocytes, the epidermal cells responsible for the melanin synthesis, melanossomes do the process with the transcription of key enzymes by the microphtalmia-associated transcription factor, conversion of L-tyrosine in dopaquinone by tyrosinase and subseque…
(Only some records are available in English at this moment)
Due to its metastatic and highly proliferative capacity, melanoma is the skin cancer with the highest mortality rate, although it is a minor incident. This scenario is mainly due to the waiting aspect in the MAPK pathway, mainly in the BRAFV600E protein, which exacerbates signals of growth, survival, invasion, and blocking of cell death. In this sense, the development of BRAF inhibitors (…
The skin is the largest organ in the human body and its main function is to act as a barrier against external agents. Atopic dermatitis (AD) is one of the most prevalent inflammatory skin diseases and is considered an expensive and difficult-to-control disease. It is estimated that at least 230 million people worldwide are affected by this condition. AD is a chronic disease that involves …
Human exposure to nickel (Ni), including dermatological exposure, result from contact with objects containing this metal, occupational exposure and environmental pollution. Ni is considered a skin sensitizing metal and allergies induced by it are among the main causes of contact dermatitis in industrialized countries. It is well demonstrated that, under physiological conditions, Ni in met…
(Only some records are available in English at this moment)
Melanoma is the most lethal type of skin cancer because it is more metastatic and has a high rate of resistance to conventional therapies, which results in a worse prognosis, especially in the elderly. About 50% of melanoma casa involve a mutation in the BRAF gene, in which valine is replaced by glutamic acid at codon 600. In melanoma there is a reduction in Hippo pathway signaling and th…
Melanoma arises from melanocytes transformed from the basal lamina of the dermal-epidermal junction and harbor a remarkable proliferation, metastasis, and immune evasion capacity propelling a patient's poor prognosis. Among other types of melanomas, acral lentiginous melanoma (ALM) is a rare subtype that appears in the palm, soles, and nail bed areas, most in non-white patients. Regardles…
Colorectal cancer (CRC) remains a major public health issue. The evolutionary events that cause colorectal localized tumors to progress to metastasis remain mostly unknown. Chromosomal alterations seem to be important in the chain of events that leads to the development of CRC that cooperate with mutations of well-described tumor-associated mutations such as APC, KRAS and p53. Furthermore…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 19 / 16 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 37 / 28 | Completed scholarships in Brazil |
| 13 / 11 | Completed scholarships abroad |
| 76 / 62 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID