CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Química (FEQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Engenharia Química from Universidade Estadual de Campinas (1994) and ph.d. at Chemical Engineering from Universidade Estadual de Campinas (2006). Has experience in Chemical Engineering, focusing on Characteristic Operations of Biochemical Processes, acting on the following subjects: lipase, liposome, gas chromatography, monoacylglycerols and vinyl esters. (Source: Lattes Curriculum)
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This multidisciplinary research project aims to consolidate a microfluidic platform for the synthesis of nanomaterials and encapsulation of repositioned therapeutic compounds. These formulations will be evaluated in spheroids operating in perfusion mode, emphasizing the strategy of drug-sustained release and microfluidic systems for screening drugs for oncological treatment. As a proof of…
This research project involves the activities of the Laboratory of Nano&Biotechnology for Advanced Developments (LaNBDA), under the coordination of the researcher responsible for this project. The research uses emerging technologies such as microfluidics and 3D bioprinting to develop new products and processes. Microfluidics is the science and technology that involves the manipulation of …
The concept of organ-on-a-chip refers to different types of in vitro modeling or reproduction of tissues and organs by combining cells and biocompatible material. This approach has become an attractive alternative for various studies, such as drug testing. The initial push was the worldwide effort to reduce the number of lab animals used in research, by the application of the 3R's - repla…
This research project encompasses the activities of the Laboratory of Nano&Biotechnology for Advanced Developments (LaNBDA), under coordination of the responsible researcher of this project. The research activities are targeted to the microfluidics area, which is the science and technology that allow manipulation of microscale devices and handles small amounts of fluids that flow in artif…
(Only some records are available in English at this moment)
This work aims to fuse conventional liposomes (egg phosphatidylcholine/cholesterol) with cell membrane components (lipids and proteins) from the human mammary adenocarcinoma cell line (MDA-MB-231BR), which have brain tropism, advancing the construction of biomimetic nanovesicles (BNVs) with the capability to cross or interact with the blood-brain barrier (BBB). The hypothesis is that, wit…
This research project aims to produce and characterize carbon dots derived from passion fruit peel (CDCM) as a carbonaceous precursor, to complex them with flavonoids, and evaluate their neuroprotective activity in a three-dimensional model of Alzheimer's disease (AD). AD is a neurodegenerative disorder accounted for 50-75% of dementia cases worldwide, with a multifactorial cause and unkn…
Hydrogels are biomaterials widely used in tissue engineering and regenerative medicine due to their water absorption properties and biocompatibility. Among them, semi-synthetic hydrogels such as methacrylated gelatin (GelMA) and methacrylated hyaluronic acid (HAMA) stand out. These materials combine the properties of both natural and synthetic hydrogels and are commonly applied in the pro…
(Only some records are available in English at this moment)
Oral Squamous Cell Carcinoma (OSCC) is a type of cancer affecting a substantial portion of the global population, leading to premature deaths and considerable suffering among those affected. Its treatment depends mainly on surgery, radiotherapy, and chemotherapy. Chemotherapy employs cytotoxic agents that adversely impact the body, often resulting in significant side effects for patients.…
The aging of the world population and the development of degenerative diseases, such as Parkinson's and Alzheimer's, whose cures are still unknown, have required creating strategies that make it possible to study them. The development of new drugs to prevent and treat these diseases depends on drug delivery strategies that can cross the Blood-Brain Barrier (BBB). The BBB, composed of endo…
This research project aims to develop cell delivery systems based on biocompatible polymeric matrices by microfluidic technology and 3D bioprinting. A systematic study will evaluate the potential of gellan gum and fibrin to form hybrid hydrogels in order to act as macrophage encapsulation systems, attending their structural and biological needs. The development of hybrid hydrogels is a st…
(Only some records are available in English at this moment)
The therapeutic use of growth factors is fundamentally limited by their short biological half-lives, and rapid enzymatic degradation in physiological environments. These constraints significantly reduce their bioavailability and require the development of delivery systems capable of protecting the protein while ensuring controlled release. Nanoparticle-based carriers have emerged as a pro…
Wound healing remains a significant clinical challenge, particularly in the treatment of chronic and complex skin injuries. In this context, tissue engineering offers promising strategies through the development of biomaterials that can support and enhance the regenerative process. In this sense, this study will focus on training in 3D bioprinting and co-culture techniques for layered ski…
The aging of the world's population and the development of degenerative diseases such as Alzheimer's, whose cure is still unknown, have required the creation of new strategies that make it possible to study them more efficiently and quickly. However, developing new drugs to prevent and treat these diseases depends on drug delivery strategies that can cross the blood-brain barrier (BBB). T…
Gene therapy is a therapeutic strategy based on the intracellular delivery of genetic material (DNA or RNA). It is particularly promising to treat severe diseases for which the pathophysiology and genetic targets are known, e.g., cancer. In general, the success of gene therapy depends on (I) the protection of genetic material against nuclease-mediated degradation in the body fluids and (I…
Over the past decades, several comprehensive studies have led to the discovery of efficient treatment or prevention methods against genetic diseases. Among all methods, gene therapy, which is the introduction of suitable genetic material into specific cells to correct the abnormal genes, came out as a critical approach for this purpose. One of the crucial steps of gene therapy is understa…
(Only some records are available in English at this moment)