Bachelor degree in Biomedical Sciences by the Federal University of Sao Paulo (2002). Graduated in Molecular Biology by the Federal University of Sao Paulo (2007), participating also in a graduate exchange program at the Max-Delbrück Institute for Molecular Medicine (Berlin, Germany). Postdoctoral fellow at Joslin Diabetes Center/Harvard Medical School (Boston, USA). Assistant Professor at the Department of Biophysics of the Federal University of Sao Paulo from 2011 to 2016. Currently holds a position of Associate Professor in the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, serving as the head of Department from 2017 through 2021. He was also Research Coordinator of the Institute of Biology in the period of 2018-2020. Expertise in Molecular Biology with emphasis in Metabolism, dedicated mainly in investigating the molecular mechanisms associated with the Metabolic Syndrome and the Aging process. Former affiliated member of the Brazilian Academy of Sciences. (Source: Lattes Curriculum)
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| Worm may help put the brakes on aging |
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This research proposal aims to discover the role of N6-methyladenosine (m6A) RNA methylation in sorting and packaging of microRNA (miRNA) into the extracellular vesicles during obesity and diabetes. The m6A methylation in eukaryotes is primarily operated by three key protein complexes: "writers" (methyltransferases), "erasers" (demethylases), and "readers" (m6A effector complex). "Writers…
The project "Uncovering Adipose-Brain Crosstalk in Alzheimer's Disease" investigates the role of adipose tissue (AT)-derived microRNAs (miRNAs) in Alzheimer's disease (AD) pathogenesis. The central hypothesis is that miRNAs produced by AT can cross the blood-brain barrier, directly influence neuronal function, and contribute to disease progression. Using animal models and post-mortem samp…
The present proposal aims to request resources for the acquisition of two medium-sized EMUs, which will be installed and made available at LaCTAD for the entire national scientific community: a platform for multiplex dosing of up to 500 analytes (xMAP intelliflex System from Luminex) and a platform for ultrasensitive immunoassays with biomarkers (Simoa SR-X from Quanterix). With this, the…
(Only some records are available in English at this moment)
A number of pathways have been shown to regulate animal lifespan and organismal aging. The Antebi lab has recently discovered the nucleolus as a crucial focal point for these pathways. The nucleolus is a subnuclear organelle dedicated to rRNA production and ribogenesis, which also controls other key processes in the RNA metabolism of the cell, including small RNA processing and assembly o…
COVID-19 has recently emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mechani…
Dr. Jeremie Boucher is a Principal Scientist at AstraZeneca, R&D CVMD iMed and Group Leader at the Wallenberg Centre for Molecular and Translational Medicine in the University of Gothenburg, where he leads bench-to-bedside projects focused on finding new molecules targeting metabolic diseases. Dr. Boucher and AstraZeneca have established a collaboration with the laboratory of Dr. Marcelo …
(Only some records are available in English at this moment)
The global prevalence of obesity and type 2 diabetes mellitus has reached epidemic levels, now recognized as a critical health crisis of the 21st century. Lifestyle interventions are essential and first-line treatment for managing these metabolic disorders. Within this context, caloric restriction (CR) stands out as a longstanding and promising strategy for improving glucose homeostasis, …
Aging is a natural process that occurs across species, leading to a decline in adaptive homeostasis and reducing the organism's resistance to stressors, increasing the risk of chronic or infectious diseases. Caenorhabditis elegans is a model organism that facilitates experimental studies of aging due to its transparency, short lifespan, and ease of genetic manipulation. This organism has …
Ageing is a natural process that affects all living beings. With advances in veterinary medicine, dogs have been living longer and longer and are more likely to reach old age. Pathological ageing is a degenerative process that affects the functions of various organs and tissues, including the central nervous system. Canine Cognitive Dysfunction Syndrome (CCDS) is a progressive neurodegene…
(Only some records are available in English at this moment)
The challenge posed by aging is escalating with the global increase in life expectancy. As the elderly population expands, the incidence of chronic non-communicable and infectious diseases also rises, imposing a burden on public health systems. Aging is characterized by a progressive reduction in the body's functions, spanning from molecular aspects to entire systems, including the immune…
Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of the metabolic syndrome and it affects more than 25% of the global population. Due to its complexity and still not completely elucidated underlying etiology, NAFLD remains without approved pharmacological treatment. Obesity and lipodystrophy are both associated with adipose tissue dysfunction and ectopic l…
The processes of aging and decline in the functioning of the immune system are strongly related, and the nematode Caenorhabditis elegans has been shown to be an appropriate model for the study of both. Caloric restriction is an intervention capable of modulating the activity of signaling pathways related to both the control of lifespan and the functioning of the immune system. A compound …
(Only some records are available in English at this moment)
Cardiometabolic diseases are a public health issue, and they have high incidence in the elderly and obese individuals. Among the demographic, anthropometric and histopathological characteristics associated with cardiometabolic disease risk, adipocyte size is more associated with diabetes than age or fat percentage. Larger adipocytes can limit the capacity of adipose tissue to store lipids…
Metabolic syndrome affects 25% of the adult population, emerging as one of the largest public health concerns worldwide. Obesity, insulin resistance and impaired glucose metabolism are the main drivers of metabolic syndrome. Adipose tissue dysfunction is intimately linked to the onset of these conditions, and this is associated with the ability of adipocytes to synthesize and secrete micr…
Cardiovascular diseases (CVD) are the main cause of death worldwide, being responsible for around 31% of all deaths whereas obesity is an independent risk factor for the development of CVDs. Adipocytes extensively communicate with other organs via hormones called adipokines, and, as more recently demonstrated, via microRNAs (miRNAs). Our group has shown that the adipose tissue expression …
Population aging represents a relevant public health issue, justifying the pursue of interventions aiming to promote health in the elderly. In the aging process, cells tend to lose the ability to properly respond to endogenous and exogenous stressors, and one relevant stress related to aging is oxidative stress. High levels of pro-oxidant molecules associated with decreased antioxidant ca…
(Only some records are available in English at this moment)
| 10 / 10 | Ongoing grants |
| 7 / 7 | Completed research grants |
| 14 / 14 | Ongoing scholarships in Brazil |
| 50 / 45 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 9 / 9 | Completed scholarships abroad |
| 91 / 86 | All research grants and scholarships |
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CV Lattes
ORCID