CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor degree in Biomedical Sciences by the Federal University of Sao Paulo (2002). Graduated in Molecular Biology by the Federal University of Sao Paulo (2007), participating also in a graduate exchange program at the Max-Delbrück Institute for Molecular Medicine (Berlin, Germany). Postdoctoral fellow at Joslin Diabetes Center/Harvard Medical School (Boston, USA). Assistant Professor at the Department of Biophysics of the Federal University of Sao Paulo from 2011 to 2016. Currently holds a position of Associate Professor in the Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, serving as the head of Department from 2017 through 2021. He was also Research Coordinator of the Institute of Biology in the period of 2018-2020. Expertise in Molecular Biology with emphasis in Metabolism, dedicated mainly in investigating the molecular mechanisms associated with the Metabolic Syndrome and the Aging process. Former affiliated member of the Brazilian Academy of Sciences. (Source: Lattes Curriculum)
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| En un gusano, los frenos del envejecimiento |
| Worm may help put the brakes on aging |
| En un gusano, los frenos del envejecimiento |
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The project "Uncovering Adipose-Brain Crosstalk in Alzheimer's Disease" investigates the role of adipose tissue (AT)-derived microRNAs (miRNAs) in Alzheimer's disease (AD) pathogenesis. The central hypothesis is that miRNAs produced by AT can cross the blood-brain barrier, directly influence neuronal function, and contribute to disease progression. Using animal models and post-mortem samp…
Early onset Alzheimer's disease (AD) affects individuals under 65 years old, which are often in a very productive phase and possess several family responsibilities leading to profound negative impacts in the patients and their families' life. Despite extensive research showing that genetic mutations in the amyloid precursor protein (APP) and presenilin 1 (PS1) genes are associated with ea…
The present proposal aims to request resources for the acquisition of two medium-sized EMUs, which will be installed and made available at LaCTAD for the entire national scientific community: a platform for multiplex dosing of up to 500 analytes (xMAP intelliflex System from Luminex) and a platform for ultrasensitive immunoassays with biomarkers (Simoa SR-X from Quanterix). With this, the…
(Only some records are available in English at this moment)
This research proposal aims to discover the role of N6-methyladenosine (m6A) RNA methylation in sorting and packaging of microRNA (miRNA) into the extracellular vesicles during obesity and diabetes. The m6A methylation in eukaryotes is primarily operated by three key protein complexes: "writers" (methyltransferases), "erasers" (demethylases), and "readers" (m6A effector complex). "Writers…
A number of pathways have been shown to regulate animal lifespan and organismal aging. The Antebi lab has recently discovered the nucleolus as a crucial focal point for these pathways. The nucleolus is a subnuclear organelle dedicated to rRNA production and ribogenesis, which also controls other key processes in the RNA metabolism of the cell, including small RNA processing and assembly o…
COVID-19 has recently emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mechani…
(Only some records are available in English at this moment)
Adipose tissue acts as an endocrine organ, releasing hormones and microRNAs (miRNAs) that modulate metabolic processes. Recent evidence suggests that miRNAs produced by adipocytes, transported via extracellular vesicles, can cross the blood-brain barrier and exert their effects on the central nervous system (CNS). Alterations in the biogenesis or profile of these miRNAs are associated wit…
The project aims to deepen the understanding of the effects of N-Heptanoylglycine (C7-Gly), a medium-chain N-acylglycine (CM-NAG), over energy metabolism. C7-Gly has been identified as decreased in the circulation of rodents subjected to dietary restriction (DR) and demonstrates the ability to stimulate the gene encoding uncoupling protein 1 (UCP1) in brown adipocytes. Within the scope of…
O transplante autólogo de tecido adiposo é uma técnica estética e terapêutica amplamente utilizada para remodelação corporal e regeneração de estruturas danificadas. O bolsista buscará compreender a heterogeneidade celular e molecular do tecido adiposo usado na lipoenxertia facial, aprimorando a eficácia e a segurança do procedimento. O bolsista investigará o perfil celular em amostras de…
(Only some records are available in English at this moment)
The scientific community faces a unique challenge: to restore public trust in the scientific knowledge produced by laboratories, along with effectively communicating this knowledge to the general population. Laboratories have struggled to maintain this dynamic, given the high demands for productivity and the lack of training in scientific communication. Therefore, this project aims to cre…
Ageing is a natural process that affects all living beings. With advances in veterinary medicine, dogs have been living longer and longer and are more likely to reach old age. Pathological ageing is a degenerative process that affects the functions of various organs and tissues, including the central nervous system. Canine Cognitive Dysfunction Syndrome (CCDS) is a progressive neurodegene…
Lipodystrophy is defined as a heterogeneous set of metabolic disorders resulting from dysfunction of adipose tissue in its ability to accumulate lipids, commonly leading to insulin resistance, dyslipidemia and increased risk of cardiometabolic diseases. miRNAs are small non-coding molecules and endogenous regulators of gene expression, which are generated through the processing by the end…
(Only some records are available in English at this moment)
The study investigates thymic involution in the context of obesity, aging, and lipodystrophy, using wild-type (Lox) and AdicerKO mice at different ages (1, 6, and 18 months), fed either a standard diet (chow) or a high-fat diet (HFD). Histological analysis (H&E) revealed progressive structural changes in the thymus: at 6 months, AdicerKO on a chow diet and Lox on HFD already showed partia…
Cardiometabolic diseases are a public health issue, and they have high incidence in the elderly and obese individuals. Among the demographic, anthropometric and histopathological characteristics associated with cardiometabolic disease risk, adipocyte size is more associated with diabetes than age or fat percentage. Larger adipocytes can limit the capacity of adipose tissue to store lipids…
Metabolic syndrome affects 25% of the adult population, emerging as one of the largest public health concerns worldwide. Obesity, insulin resistance and impaired glucose metabolism are the main drivers of metabolic syndrome. Adipose tissue dysfunction is intimately linked to the onset of these conditions, and this is associated with the ability of adipocytes to synthesize and secrete micr…
Cardiovascular diseases (CVD) are the main cause of death worldwide, being responsible for around 31% of all deaths whereas obesity is an independent risk factor for the development of CVDs. Adipocytes extensively communicate with other organs via hormones called adipokines, and, as more recently demonstrated, via microRNAs (miRNAs). Our group has shown that the adipose tissue expression …
(Only some records are available in English at this moment)