CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba (FOP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Odontologia from Universidade Estadual de Campinas (1992), graduation at Odontologia from Universidade Estadual de Campinas (1992), master's at Odontology from Universidade de São Paulo (1996) and doctorate at Odontology from Universidade de São Paulo (1999). He is currently professor doutor at Universidade Estadual de Campinas. Has experience in Microbiology, focusing on Microbiology, acting on the following subjects: streptococcus mutans, cárie dentária, dental caries, odontopediatria and reabilitação bucal. (Source: Lattes Curriculum)
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Streptococcus sanguinis is an abundant commensal species of the oral cavity with a high capacity to initiate dental biofilms. By mechanisms still poorly understood, S. sanguinis is also a common opportunistic pathogen of cardiovascular diseases, including infective endocarditis and atherosclerotic diseases. Previous studies of our research group indicate three genes consistently associate…
Streptococcus sanguinis is a ubiquitous commensal species of the oral microbiome associated with cardiovascular infections by mechanisms as yet to be understood. Recently, we verified that S. sanguinis strains can invade and persist in human coronary arterial endothelial cells (HCAEC), an important function for bacterial persistence in cardiovascular tissues. There is evidence that this p…
Streptococcus sanguinis (Ss) is a pioneer species of teeth, which inhibits pathogenic species of dental biofilms, but is frequently involved in infective endocarditis through mechanisms as yet unknown. Our recent results indicate that S. sanguinis has low susceptibility to deposition of C3b/iC3b of the complement system, a major opsonin involved in blood clearance by neutrophils (PMN). Th…
Streptococcus mutans (SM) is a common bacterial species of the oral cavity of humans involved in the pathogenesis of dental caries, which can promote bacterial endocarditis after gaining access to the bloodstream. Little is known about the virulence factors involved in the ability of this species to survive in the bloodstream to cause systemic infections. During the process of colonizatio…
(Only some records are available in English at this moment)
Streptococcus sanguinis is an abundant commensal species of the oral cavity with a high capacity to initiate dental biofilms. By mechanisms still poorly understood, S. sanguinis is also a common opportunistic pathogen of cardiovascular diseases, including infective endocarditis and atherosclerotic diseases. Previous studies of our research group indicate three genes consistently associate…
Streptococcus sanguinis is an abundant commensal species in the oral cavity, capable of initiating the formation of dental biofilms. Bacteria of this species are commonly involved in cases of infectious endocarditis (IE) in susceptible individuals and are also detected in atherosclerotic plaques. Streptococcus sanguinis expresses three genes, spxB, swan, and nox, potentially involved in c…
Streptococcus mutans and Streptococcus sanguinis are ubiquitous species of the dental biofilms, commonly involved in opportunistic cardiovascular infections, such as infective endocarditis (IE). There is evidence that systemic infections promoted by these bacteria involve a restricted sub-set of strains with increased expression of virulence genes, as consequence of spontaneous mutations …
Streptococcus sanguinis is an abundant commensal species of the oral cavity, which initiates tooth colonization, modulating the maturation of dental biofilms, and which can further promote opportunistic cardiovascular infections. These functions likely reflect the ability of S. sanguinis strains to adapt to oral and/or extra-oral environments, through the expression of a panel of signal …
Although Streptococcus sanguinis is one of the most common bacterial species of the oral microbiome associated with cardiovascular infections, its molecular mechanisms of virulence remain poorly understood. The gene nox, encoding for an NADH oxidase, was associated with S. sanguinis virulence in an in vivo model of infectious endocarditis by mechanisms as yet to be elucidated. In our pre…
Streptococcus sanguinis is a major comensal species of streptococci, which initiates tooth colonization and which modulates the maturation of dental biofilms. However, the molecular mechanisms involved in its capacity to form biofilms are poorly understood. As a pioneer species of dental surfaces, S. sanguinis needs to bind to the acquired dental pellicle (AP) and to produce exopolymers t…
(Only some records are available in English at this moment)
Streptococcus sanguinis is a commensal bacterium of the oral cavity frequently associated withinfective endocarditis (IE) and atherosclerosis. This species has particular ability to persist in the bloodstream to, eventually, infect cardiovascular tissues. No specific set of virulence genes has been detected in strains associated with cardiovascular infection as compared to commensal oral …
Streptococcus mutans (SM), a major pathogen of dental caries, can promote infective endocarditis and other systemic infections after accessing the bloodstream. Previously, we showed that mutants defective in CovR, a transcriptional repressor of genes for oral virulence, are resistant to phagocytosis by human PMN in a blood-dependent way. In the PhD fellowship project associated with this …
This project aims to complement the Scientific Initiation Research Project entitled "Analysis of the patterns of antibiotic sensitivity in pioneer strains of Streptococci from the oral cavity". In this project, we identified in the oral cavity of 2 to 16-month-old children, a high prevalence of strains of Streptococcus salivarius, which were resistant to several classes of antibiotics (be…
| 1 / 1 | Ongoing grants |
| 11 / 7 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 25 / 15 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 44 / 30 | All research grants and scholarships |
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