CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from Universidade Estadual do Norte do Paraná (2008). Master in Genetics and Molecular Biology from Universidade Estadual de Londrina (2011). PhD in Biology/Genetics from University of São Paulo (2017). Develope a research project at National Institutes of Health using patients cells who have a syndrome known as Xeroderma Pigmentosum, characterized by mutations in Nucleotide Excision Repair (NER) genes or in DNA polymerase eta that participates in the tolerance pathway (Translesion Synthesis) of DNA damage induced by UV light. The focus of the research is to evaluate the UVA-induced DNA and cell damage and its deleterious effects in these cells related to genotoxicity, oxidative stress and mutagenesis. (Source: Lattes Curriculum)
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UVA light (UVA) is an environmental agent that induces DNA (cyclobutene pyrimidine dimers - CPDs, and oxidized bases) and protein damage, which are related to exposure outcome such as skin aging and carcinogenesis. The important functions of Nucleotide Excision Repair (NER) and Translesion Synthesis (TLS) to protect against UV-induced skin cancer is evidenced by the rare hereditary diseas…
The DNA molecule is constantly exposed to the physical (like UV light) and chemical agents (such as chemotherapy or reactive oxygen species and/or nitrogen) that can cause lesions. Such lesions can interfere with important cell processes such as DNA replication and RNA transcription, which can result in mutations or cell death. Ultraviolet light (UV) is indeed a genotoxic environmental ag…
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