CV Lattes
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Hospital do Câncer de Barretos (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biotechnology from São Paulo State University, Brazil (2008). Master's degree (2010) and PhD (2014) in Health Sciences, at the São José do Rio Preto Medical School, Brazil. Postdoctoral at Barretos Cancer Hospital (BCH), Molecular Oncology Research Center (2014-2018) and PostDoctoral associate at University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, EUA (2018-2020). Experience in Genetics and Molecular Biology, working mainly in biomarker research for head and neck tumors (DNA methylation, microRNAs, mutations, polymorphisms), cell culture (2D and 3D, co-culture, spheroids and therapeutic response) and tumor immunology, mainly investigating immunological markers of response to immunotherapy (anti-PD-1/PD-L1 and anti-CTLA-4, BCG and imiquimod). Associate researcher and supervisor in the Graduate Program at Institute of Learning and Research, BCH. Coordinator of the Immuno-Oncology group and discipline at the BCH graduate program. Coordinator of the Barretos Cancer Hospital team in the international consortium HEADSpAcE (Translational studies of HEAD and neck cancer in South America and Europe), led by the International Agency for Research on Cancer (IARC) and funded by the European Union. Member of the international consortia MOONRISE (Elucidating the mutational signatures of biological and environmental causes of oral potentially malignant disorders - OPMDs), coordinated by IARC; and Melcaya (Melanomas in Children, Adolescents and Young Adults), both funded by the European Union. Associate Researcher in the FAPESP Thematic Project LOOPS (Identification of non-invasive methods for the early diagnosis of squamous cell carcinoma of the oral cavity and oropharynx) coordinating the Methylome sub-project. (Source: Lattes Curriculum)
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Lung cancer causes 1.8 million deaths annually, representing the highest cancer mortality rate, with 85% of patients falling under non-small cell lung cancer (NSCLC). Immunotherapy targeting immune checkpoint inhibitors (ICI) has shown significant advances, employing monoclonal antibodies to modulate co-stimulatory and co-inhibitory signals crucial for immune tolerance maintenance. Despit…
The BD FACSymphony A5 is a cell analyzer that uses the principle of flow cytometry. The equipment has 3 lasers: blue (488nm), red (640nm) and violet (405nm). All three lasers will have a power equal to 100mW and will allow the operator to control them individually via software (on, off and power adjustments). The instrument will be equipped with 21 independent detectors, allowing 21 diffe…
(Only some records are available in English at this moment)
Introduction: Melanoma is a highly lethal cancer with a rising global incidence. Immunotherapy has revolutionized the management of advanced melanoma, significantly improving patient survival. However, challenges such as treatment resistance, tumor heterogeneity, and high costs still limit its overall effectiveness. The identification of response biomarkers emerges as a strategy to select…
INTRODUCTION: Melanoma stands out in the oncological landscape due to its high lethality and invasive capacity. Immunotherapy with immune checkpoint inhibitors (ICI) has demonstrated improvements in survival rates for patients with advanced melanoma. However, there are currently no approved biomarkers for application in clinical practice. In this context, new studies are crucial for the i…
Justification: The heterogeneous clinical outcomes observed in patients with advanced melanoma treated with immune checkpoint inhibitors highlight the need to identify predictive biomarkers of response. In this context, the BRAF gene emerges as a potential predictive biomarker due to its activating mutations found in approximately 50% of melanomas, which induce a tumor microenvironment di…
(Only some records are available in English at this moment)
Background: Several studies aim to improve the diagnosis and treatment of melanoma, emphasizing immunotherapy due to its significant contribution to improving the prognosis in these patients. However, half of patients with metastatic melanoma do not obtain durable survival benefits, motivating the search for markers that identify non-responsive patients. Although histopathological evaluat…
(Only some records are available in English at this moment)
Melanoma, although less common, is the most invasive and lethal cutaneous neoplasm, with an increasing incidence, particularly among individuals with fair skin. Treatment strategies for melanoma include surgery, chemotherapy, radiotherapy, and immunotherapy, with immune checkpoint inhibitors (ICIs) showing significant efficacy in metastatic melanoma. These ICIs target molecules such as CT…
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver cancer with limited treatment options and poor prognosis. The tumor microenvironment (TME) significantly influences iCCA progression, drug resistance, and immune evasion. Single-cell and multiomics studies have revealed complex interactions between cancer cells, hepatic stellate cells (HSCs), cancer-associated fibroblasts (CAFs…
Lung cancer causes 1.8 million deaths annually, representing the highest cancer mortality rate, with 85% of patients falling under non-small cell lung cancer (NSCLC). Immunotherapy targeting immune checkpoint inhibitors (ICI) has shown significant advances, employing monoclonal antibodies to modulate co-stimulatory and co-inhibitory signals crucial for immune tolerance maintenance. Despit…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 9 / 9 | Ongoing scholarships in Brazil |
| 13 / 11 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 31 / 29 | All research grants and scholarships |
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