CV Lattes
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Sociedade Beneficente de Senhoras (SBSHSL). Hospital Sírio-Libanês (Institutional affiliation from the last research proposal) Birthplace: Brazil
He holds a degree in Molecular Sciences from the University of São Paulo (2003), completed his Ph.D. in Biochemistry, also at the University of São Paulo (2007), and conducted postdoctoral research at Harvard University in the USA (2008). Between 2009 and 2011, he held the position of Senior Researcher at the Ludwig Institute for Cancer Research. He served on the board of the Brazilian Association of Bioinformatics and Computational Biology (AB3C) from 2010 to 2014. Currently, he is a Senior Researcher at Instituto Sírio-Libanês de Ensino e Pesquisa do Hospital Sírio-Libanês, deputy coordinator of the Postgraduate Program in Health Sciences at the Hospital Sírio-Libanês and also works as a Volunteer Professor at the University of São Paulo (Department of Biochemistry). His expertise encompasses Bioinformatics, Computer Science, Molecular Biology, Genomics, and Cancer research. His research interests include a profound understanding of the following topics: i) Exploring the function of retrotransposable elements in the human genome and in other mammals, aiming to unveil their functional implications. ii) Investigating the role of post-transcriptional gene regulation in the origin and maintenance of tumoral processes, contributing to a broader and more comprehensive knowledge of cancer. iii) Identifying new biomarkers and therapeutic targets for aggressive tumors, aiming to develop more effective treatment strategies. iv) Developing innovative computational tools and algorithms in the fields of bioinformatics, genomics, and transcriptomics, enhancing the analytical and interpretive capacities of these research areas. Currently, he has more than 100 scientific articles published in high-impact international journals and has successfully mentored students who are now active in renowned institutions in Brazil, the United States, and Europe. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| The era of whole genome sequencing |
| La era de la secuenciación completa de genomas |
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| News published in Agência FAPESP Newsletter about the researcher |
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been causing a pandemic of unprecedented rate in human history. In about 3.5 months of the disease, this virus has infected more than 2.5 million people, causing more than 177,000 deaths. Initially, it was believed that people affected by SARS-CoV-2 would be almost exclusively those with pre-existing chronic diseases and…
The origin of new gene regions is a preponderant factor in the evolution of several species. Retrocopies (gene duplicates generated from mRNAs) have been classified as non-functional since 1980s. However, it is currently accepted that this type of gene duplication is one of the main driving forces in generating genetic novelties in many species. In humans and mice, have been identified ~8…
Dr. Luiz O. Penalva and Dr. Pedro AF Galante have a long time of collaborations in the fields of cancer genomics, bioinformatics and RNA binding proteins (RBPs). They were funded by agencies, such as CNPq (400262/2014-2), FAPESP (2013/25483-4; 2013/07159-5) and NIH (R21CA205475-01) along the past. Over the past four years, Dr. Penalva visited Dr. Galante's laboratory (CNPq funding (400262…
(Only some records are available in English at this moment)
Retrocopies are processed messenger RNA copies that originate through reverse transcription-mediated protein-encoded LINE-1 elements. Retrocopies were first identified in the 1980s in humans and subsequently in several other species, and are therefore considered a recurrent event during mammalian evolution. The complete sequencing of the Human Genome in the 2000s and the subsequent advanc…
Retrotransposons are a class of mobile DNA elements that utilize an RNA intermediate to move within the genome. These elements are categorized into LTR retrotransposons (derived from ancestral exogenous infections by retroviruses) and non-LTR retrotransposons (mainly LINEs and SINEs). Moreover, occasionally, the machinery of LINEs can capture other mature mRNAs (in trans) and re-insert th…
It is well known that malignant tumors exhibit an altered pattern of gene expression, with several genes being overexpressed or underexpressed. Our group and others have identified expressed retrocopies capable of regulating the expression of their parental protein-coding genes or genes neighboring the insertion site. Here, we hypothesize that retrocopies without a known function may play…
Currently, it has been reported several expressed retrocopies. However, due to the high similarity between retrocopies and their respective parental genes, it is still a challenge to accurately measure the expression profile of these gene copies. Additionally, a large fraction of this "JP-2" project is based on the investigation of expressed retrocopies. Thus, here we propose to build an …
Currently, it has been reported several expressed retrocopies. However, due to the high similarity between retrocopies and their respective parental genes, it is still a challenge to accurately measure the expression profile of these gene copies. Additionally, a large fraction of this "JP-2" project is based on the investigation of expressed retrocopies. Thus, here we propose to build an …
(Only some records are available in English at this moment)
Retrocopies, also known as retroposed copies or processed pseudogenes, arise from the reverse transcription and subsequent integration of messenger RNA (mRNA) molecules into the genome. While many retrocopies were historically considered non-functional pseudogenes, advancements in OMICs technologies and bioinformatics have unveiled a myriad of potentially functional retrocopies. The human…
The brain is unique in evolutionary terms, allowing humans to perform complex tasks such as thinking and memory formation. Likewise, the difficulty observed for many years in studying this organ is equally notorious. Fortunately, a recent and powerful cellular tool, the cerebral organoids ("minibrains"), have boosted the way we investigate brain development and neuronal disorders, such as…
Transposable elements were discovered in the 1940s, but their importance in genome composition, evolution and its role as regulatory elements occurred after the development of DNA sequencing methodologies. Those elements can be subdivided in two classes, DNA-transposons and retrotransposons, being the latter our focus of interest. Retrotransposition process is mediated by an enzymatic mac…
(Only some records are available in English at this moment)
| 6 / 5 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 17 / 15 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 29 / 26 | All research grants and scholarships |
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