graduate at Ciências Biológicas-Modalidade Médica from Universidade Federal de São Paulo (2001) and ph.d. at Microbiology from Universidade Federal de São Paulo (2007). Has experience in Biochemistry, focusing on Biochemetry of the Microorganisms (Source: Lattes Curriculum)
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The regulation of gene expression is crucial for the adaptation and survival of Trypanosoma cruzi, the etiological agent of Chagas disease. Specifically, post-transcriptional regulation has been described as fundamental in this process, as gene transcription occurs polycistronically (PTU), meaning that multiple genes are transcribed on a single messenger RNA (mRNA) strand. However, mechan…
At JP1, our group described many chromatin-associated proteins as well as more than 40 histone PTMs, differentially expressed in replicate versus non-replicative life forms of Trypanosoma cruzi. Classical eu- and heterochromatin regions are presented at their nucleus and changes dramatically during differentiation from epimastigotes to metacyclics (EàM). Traditionally, these chromatin reg…
Pathogenic trypanosomatids such as Leishmania spp. and Trypanosoma cruzi are the causative agents of leishmaniosis and Chagas disease, a group of neglected diseases endemic in the tropical and subtropical belt of the planet and the Americas, respectively. The therapeutic approaches against these diseases are largely unsatisfactory due to toxicity and emergence of resistance. Thus, new dru…
Trypanosoma cruzi is a unicellular eukaryote, a causative agent of Chagas disease that alternates between replicative and non-infective forms (epimastigotes and amastigotes) and non-replicative and infective forms (cellular and blood trypomastigotes). Differentiation between these forms is accompanied by differences in overall transcript levels and structural changes in chromatin. Several…
The nucleus is a complex organelle composed of nucleic acids and proteins in a tight relationship. The nuclear proteome, specially the chromatin proteome, plays a role in the regulation and management of genome that ultimately controls gene expression and cell phenotype. Many evidences demonstrate an important role of nucleus and chromatin in eukaryotic cell cycle control. The fibroblast …
The regulation of gene expression is crucial for the adaptation and survival of Trypanosoma cruzi, the etiological agent of Chagas disease. Specifically, post-transcriptional regulation has been described as fundamental in this process, as gene transcription occurs polycistronically (PTU), meaning that multiple genes are transcribed on a single messenger RNA (mRNA) strand. However, mechan…
Trypanosoma cruzi is the parasite that causes Chagas disease. Recently it was proposed that its genome is organized in two compartments: the central compartment - composed of highly conserved genes, and the disruptive compartment - composed of rapidly evolving genes, such as trans-sialidase, mucins and MASP virulence genes. Our group showed enrichment of histone H2B variant (H2B.V), a mar…
In trypanosomes, it is general accepted that gene expression is mainly regulated by post transcriptional mechanisms due to the lack of classical RNA Pol II promoters regions and policistronic transcription. However, previous low-scale run-on experiments indicate that satellites genes have lower expression, and a significant decrease in global transcription is observed when replicative for…
At JP1, our group described many chromatin-associated proteins as well as more than 40 histone PTMs differentially expressed in replicate versus non-replicative life forms in Trypanosoma cruzi. Classical eu- and heterochromatin regions are presented at their nucleus and changes dramatically during differentiation from epimastigotes to metacyclics (EàM). Traditionally, these chromatin regi…
Trypanosoma cruzi has peculiarities in genomic organization and gene expression where genes are transcribed into polycistronic transcription units. Mitosis in T. cruzi occurs with semi-condensation of the chromosomes hampering the application of classical cytogeneticsapproaches. The karyotype was determined by molecular biology techniques. Among the genomic characteristics of T. cruzi, fe…
Parasites will be subject to different metabolic backgrounds, such as severe metabolic stress by incubating them in deprivation of nutrients (PBS buffer) or under metabolic stress conditions with single carbon and energy sources for maintenance (PBS supplemented with glucose, proline, histidine or leucine). In parallel, parasites in different cell cycle stages will be obtained by cell sor…
(Only some records are available in English at this moment)
This proposal is designed to address nuclear three-dimensional features of two life forms of the parasite Trypanosoma cruzi, and to investigate its probable impacts on different aspects of T. cruzi biology. Gene expression in trypanosomes is broadly determined by post-transcriptional mechanisms, however, a significant decrease in global transcription has been observed if comparing their l…
Despite being a growth factor, FGF2 has anti-proliferative and tumor suppressive functions in some cellular contexts. In Y1 murine adrenocortical carcinoma cell line, the FGF2 promotes G0-G1 transition but delays S-phase and permanently blocks cells in G2/M. To better understand the chromatin response to proliferative and anti-proliferative stimuli induced, respectively, by Fetal Bovine S…
Despite being a growth factor, FGF-2 has anti-proliferative and tumor suppressive functions in some cellular contexts. In a murine adrenocortical tumor cell line (lineage Y1), FGF-2 triggers an initial mitogenic response through ERK1/2, PKC and AKT signaling but results in a G2/M cell cycle arrest through RhoA/GTP-src signaling. Recently, we found transcription factors related to early-ge…
| 2 / 2 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 15 / 12 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 26 / 23 | All research grants and scholarships |
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CV Lattes
ORCID