Abstract
Introduction: Previous studies from our research group (FAPESP Process No. 2012/02083-8 and 2012/02565-2; Prope-UNESP 005 /2011) demonstrated in an animal model that endodontic infection exerts effects on systemic health as well as certain systemic changes can modulate the development of endodontic infection (Cintra et al, 2013abc; 2014ab). Thus, we believe it is important to study therap…