CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor of Virology at the University of São Paulo School of Medicine (FMRP-USP). Physician, graduated from Federal University of Ceará - UFC (1981); Resident in Internal Medicine (UFC/1982-1983); and later in Clinical Pathology (University of Virginia/1996). Master's degree from Federal UNiversity of Sao Paulo - UNIFESP (1987); and PhD also from UNIFESP with Thesis developed at the University of Virginia (UVA) School of Medicine (1991). Was a postdoctoral reaesrch fellow in Virology at the University of Virginia (1992-1993). Joined the faculty at UVA as Research Assistant Professor of Virology (1993-1996). Runs the Viral Pathogenesis Laboratory in the Virology Research Center, at FMRP-USP. He is Fellow of the American Academy of Microbiology since 2014; was president of the Brazilian Society for Virology (2013-2014); Chairman, Department of Cellular and Molecular Biology at FMRP-USP (2020-2022); and President of the FMRP-USP Research Committee (2016-2020). He is advisor in the Postgraduate Programs in Cellular and Molecular Biology; and Otorhinolaryngology, both at FMRP-USP. He does research on pathogenesis and persistence of human respiratory viruses, including SARS-CoV-2, Oropouche virus, and vertical transmission of viruses. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| El virus evoluciona |
| The evolution of a virus |
| Natural guests |
| Los huéspedes naturales |
| Novel coronavirus in Brazil |
| El nuevo coronavirus llegó a Brasil |
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| News published in Agência FAPESP Newsletter about the researcher |
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| TITULO |
| Articles published in other media outlets ( ): |
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| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Little is known about the importance of the maternal virome in modulating the immune system of the fetus or newborn. The studies are focused on intrauterine, perinatal or postnatal vertical transmission of infectious viruses, on the pathogenesis of congenital infections and on therapeutic interventions to be carried out during the infection of a pregnant or lactating woman. However, it is…
This thematic research project is proposed based on a central backbone of research on viruses of great importance for human health. The proposal comes from five collaborative research groups, led by established professors, and consists of subprojects distributed in four major areas of work: 1) Virus-cell interaction; 2) Pathogenesis of viral infections; 3) Diagnosis and prospection of hum…
This thematic research project is proposed based on a central backbone of research on viruses of great importance for human health. The proposal comes from five collaborative research groups, led by established professors, and consists of subprojects distributed in four major areas of work: 1) Virus-cell interaction; 2) Pathogenesis of viral infections; 3) Diagnosis and prospection of hum…
(Only some records are available in English at this moment)
Rhinovirus (VR) is the infectious agent that most frequently affects the human species, causing acute respiratory infections (ARI), and is often associated with exacerbations of asthma and chronic bronchitis / emphysema, as well as secondary complications such as sinusitis and otitis media. Studies done by our group have shown that RV often infects tonsils and is excreted in nasopharyngea…
This thematic Project includes 29 subprojects, focusing on emerging zoonotic viruses of the family Bunyaviridae, distributed in 3 genera: Orthobunyavirus, Phlebovirus and Hantavirus. The project involves 3 Principal Researchers, 55 Brazilian and international collaborators, and will take 4 years. For studies on the genus Orthobunyavirus, serological diagnosis of Oropouche virus (OROV) by …
Infections caused by human paramyxoviruses have great impact in public health, but little is known about their pathogenesis. Evidence recently produced by our group suggests that these agents frequently persist in lymphoid tissue of human tonsils. Such tonsillar persistence of paramyxoviruses is importante because of the possible pathogenic and immunologic consequences, as well as because…
(Only some records are available in English at this moment)
The seasonal recurrence of viral respiratory diseases, such as Influenza A, and the increasing incidence of SARS-CoV-2 represent significant challenges in understanding the mechanisms underlying persistent viral infections. Mitochondrial dysfunctions may compromise the immune response, facilitating chronic infections. The S1PR1 receptor plays a crucial role in T cell response and mitochon…
The Oropouche virus (OROV) is a human pathogen transmitted by arthropods and widely distributed in tropical regions such as Central and South America, mainly present in the Amazon region. The OROV genome consists of three RNA strands named L, M, and S, where M and S encode the non-structural proteins NSm and NSs, respectively. Since the initial identification of the virus, a large number …
(Only some records are available in English at this moment)
SARS-CoV-2 is the virus responsible for the COVID-19 disease, a severe acute respiratory syndrome. One key aspect in understanding SARS-CoV-2 infection is the activation of the NLRP3 inflammasome. Our study aims to assess this activation in response to infection by clinically relevant variants of SARS-CoV-2 (Wuhan, Gamma, Delta, and Omicron) in THP1 monocytic lineage cells. To do so, we w…
Chronic rhinosinusitis is characterized as a pathology of multifactorial and chronic nature. One of its classifications is based on the presence or absence of nasal polyps, benign masses whose etiology remains unknown. Respiratory viruses affect both the lower and upper respiratory systems and can be of different classes, such as those used in this work: rhinoviruses (major and minor) and…
Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a prevalent pathology characterized by persistent inflammation in the nasal cavities and paranasal sinuses, which affects the nasal mucosa, causing important tissue remodeling. Respiratory viruses such as Rhinovirus (RV) and SARS, highly prevalent and distributed in the world population, commonly infect the nasal mucosa and can, in a ca…
(Only some records are available in English at this moment)
Respiratory syncytial virus (RSV) is the most important viral cause of severe respiratory infections in children worldwide. RSV infects the respiratory epithelium and is also frequently detected in CD4+ T cells from secondary lymphoid tissues of asymptomatic patients. Host factors such as progressive loss of immune functions, and impaired production of cytokines favor the maintenance of p…
Influenza viruses cause more than two million annual episodes of seasonal acute respiratory infections (ARI) and approximately 500 thousand deaths worldwide. Evidence from literature indicates that, depending on virus strain and host immune status, infections by influenza A virus (IAV) may be asymptomatic and reach sites other than the respiratory tract. Our previous results indicated tha…
In summary, as part of their evolution, both viruses and host cells are capable to manipulate the miRNAome, kinases, and inflammasome activation to regulate the overall immune response in a virus and cell type specific fashion. Understanding changes in miRNA and kinase-expression profiles, identifying target genes and their contribution to the…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 16 / 11 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 58 / 27 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 91 / 55 | All research grants and scholarships |
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