CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a bachelor's degree in Biological Sciences from the Federal University of Rio de Janeiro (2000), a master's degree in Biological Sciences with an emphasis on Genetics from the same institution (2002), and a doctorate in Biological Sciences specializing in Biochemistry from the University of São Paulo (2005). Completed a postdoctoral fellowship in the Department of Ecology and Evolution at the University of Chicago (2010), where she also served as an associate researcher from 2011 to 2012. She was an Associate Professor at Arizona State University from 2022 to 2023 and a FAPESP Young Investigator from 2016 to 2021.Currently, she is an Associate Professor in the Department of Genetics and Evolutionary Biology at the University of São Paulo. Her expertise encompasses Genetics and Evolution, with a focus on gene expression during gametogenesis, the evolution of new genes, sex chromosomes, and bioinformatics. (Source: Lattes Curriculum)
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Cytogenetics plays a pivotal role in unraveling the complexities of chromosomal structures and dynamic protein interactions during the cell cycle. The use of fluorescence-based chromosomal labeling techniques, such as Fluorescence in situ hybridization (FISH), holds paramount significance in this context. However, comprehensive labeling of chromosomes containing highly repetitive sequence…
New genes are frequently formed during evolution in a wide variety of organisms playing a key role in the emergence of novel traits. Recently, studies have shown that new genes can quickly assume critical roles in developmental pathways by producing essential structures. Despite their importance, new genes are still seriously under-characterized in functional studies and inconsistently an…
Since the last century, meiotic sex chromosome inactivation (MSCI) has been observed in a wide range of taxonomic groups with XY sex determination, such as mammals and insects. Therefore, MSCI is considered a crucial process for the proper development of spermatogenesis. In Drosophila, several studies have unequivocally shown a reduction in gene expression from the X chromosome during mei…
ew genes are a major source of novelties and show elevated testis expression in different taxa.Studies have shown that new genes evolve by adaptive changes and, therefore, can quickly assumecritical roles in developmental pathways, by producing essential structures. Our group hasdiscovered that new genes are more often expressed in later phases (haploid) of Drosophilaspermatogenesis. We p…
Translocations between the X chromosome and autosomes are one of the greatest causes of male infertility in drosophilidae. The reason why this occur may be related with differences on the regulation and the pattern of condensation of these chromosomes so that this translocations place the chromosomes in question under asynchronous control during a important period of spermatogenesis. This…
Researches that focuses on understanding the sequence and organization of heterochromatin allows essential functions for the organism to be better understood. One of the main obstacles in studies with the Y chromosome is related to the heterochromatic state of this structure, which in Drosophila melanogaster is formed by approximately 41 Mb of highly repetitive sequences. With application…
Meiotic Sex Chromosome Inactivation (MSCI) is a process of transcriptional silencing of the sex chromosomes in the early stages of meiosis in spermatogenesis. Scientists have investigated the existence and impact of MSCI on D. melanogaster and some aspects related to spermatogenesis raised a great debate about the existence of this mechanism. During the period of the master's degree, the …
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Drosophila's Y chromosome is mainly heterochromatic and poor in gene content. The paucity of Y-linked genes does not mean that it is irrelevant for proper male development since it is essential for male fertility. To gain further understanding on their functions, we have been working with differential expression analysis along spermatogenesis of Y-linked genes. RNAseq and cytogenetic data…
The genes that have recently appeared in the evolutionary history of a taxon, through various genetic mechanisms, such as DNA-level duplication, RNA-level duplication (retroposition) and lateral transfer, are called new genes. Sincemost of them emerge by duplication, their most common fate is pseudogeneization, asthe presence of one copy is usually sufficient for itsnormal function. Howev…
In female mammals, one X chromosome is transcriptionally inactivated (XCI), leading to dosage compensation between sexes, which is fundamental for embryo viability. We recently analyzed X chromosome allele-specific expression globally during human embryonic development, and identified the XCI process to start during human preimplantation development at the blastocyst stage in a random pat…
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| 3 / 3 | Ongoing scholarships in Brazil |
| 10 / 9 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 20 / 18 | All research grants and scholarships |
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