CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1994) and doctorate at Bioquímica e Biologia Molecular from Universidade de São Paulo (2000). Has experience in Biochemistry, acting on the following subjects: células-tronco, câncer, cancer, expressao genica and terapia celular. (Source: Lattes Curriculum)
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The Animal Facilities of the Institute of Biosciences of the University of São Paulo have environments for breeding, maintaining and experimenting with amphibians, fish, reptiles, rodents, pigs and dogs. The diversity of models isan extremely important feature, enabling the research carried out at the Institute to contribute to integrated and significant advances in several areas of scien…
Neural tube defects (NTDs) are severe congenital anomalies that impact the central nervous system (CNS), posing significant public health challenges, especially in Brazil. These defects originate from malformations during the early stages of neural tube (NT) development. Despite advancements in understanding neural stem cell behavior and neurogenesis, substantial knowledge gaps persist du…
Glioblastoma multiforme (GBM) remains a formidable challenge in oncology, with limited treatment options and poor prognosis. In recent years, the emergence of immunotherapies has presented new treatment strategies based on immunotherapies, with promising results for more specific treatments that provide less cytotoxicity for patients. In particular, the development of Chimeric Antigen Rec…
Healthy aging and longevity are a growing topic of interest. They depend on the complex interplay between nuclear and mitochondrial DNA, the environment and the microbiota, that is, the whole set of bacteria living in the different parts of our body with their whole set of genes. Understanding this complex nature versus nurture balance is one of the greatest challenges in human genetics a…
The Human Genome Research Center (HGRC-CEPID I) was initiated in 2000 with the main goal of increasing our basic knowledge and diagnosis of prevalent genetic diseases in the Brazilian population. The HGRC concentrated largely on Mendelian disorders, mainly neuromuscular, craniofacial, and mental disability. The scope was expanded in 2005 by incorporating stem-cells research, both as a too…
The Human Genome Research Center (HGRC-CEPID I) was initiated in 2000 with the main goal of increasing our basic knowledge and diagnosis of prevalent genetic diseases in the Brazilian population. The HGRC concentrated largely on Mendelian disorders, mainly neuromuscular, craniofacial, and mental disability. The scope was expanded in 2005 by incorporating stem-cell research, both as a too…
(Only some records are available in English at this moment)
Glioblastoma (GBM) is the most frequent and aggressive primary malignant tumor that affects the Central Nervous System (CNS) in adults. Currently, treatment consists of surgical removal of the tumor, radiotherapy and chemotherapy, and yet the median survival of patients after diagnosis is around 15 months. Recent advances in cell therapies have increased the success in the treatment of ge…
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults, characterized by a high mortality rate and ineffective treatment options. In this scenario, CAR-T cells are considered one of the most promising emerging treatments for GBM, due to their specificity against the tumor. However, in vitro study models that accurately simulate the complex tumor conditions in…
Glioblastoma (GBM) is the most common type of central nervous system tumors, and its patients have an extremely low survival rate. One of the factors responsible for this is the inefficacy of available therapies, among which the drug Temozolomide (TMZ) stands out. This chemotherapy drug saw its use solidified after being adopted as a standard treatment protocol. Its cytotoxicity arises fr…
Glioblastoma (GBM) is an aggressive tumor that affects adult individuals. Because of this, the patient's median survival is estimated at just 15 months. Standard treatment consists of surgical resection followed by radiotherapy and chemotherapy with temozolomide (TMZ). Despite this, the tumor is highly recurrent. This pattern can be explained by the resistance GBM stem cells (GSC) acquire…
Embryonic tumors of the Central Nervous System (CNS), including Medulloblastomas (MEDs) and Atypical Rabatoid Teratoid Tumors (ATRTs), are extremely aggressive tumors that threaten the lives of children, being the main cause of Cancer-related death in the age group 0-4 years. Despite the aggressive therapeutic strategies used to treat these neoplasms (i.e. surgery, radio and chemotherapy)…
(Only some records are available in English at this moment)
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, with limited therapeutic options and poor patient survival. The failure of conventional preclinical models to replicate the cellular and molecular complexity of human brain tumors has hindered the development of effective therapies. Advances in 3D culture systems and microfluidic platforms now offe…
Hippo pathway is a phosphorylation cascade that culminates in YAP inactivation, inhibiting its activity as a transcription factor. Initially, Hippo pathway was related to the control of cell proliferation, tissue growth and stem cells phenotype. In addition, the inhibition of this pathway and hyperactivation of YAP have been related to several types of cancer. Efforts have been done to el…
Neural stem cells are regarded as new therapeutic potential for neurodegenerative diseases and injuries marrow by their ability to self-renew, proliferate and differentiate giving rise to new neural cells able to migrate to areas of injury and replacing damaged tissue. However, understanding the process of differentiation of neural stem cells is crucial to develop new cellular therapies. …