CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
D.V.M. Degree at School of Veterinary Medicine and Animal Science - USP (1989), Master's on General Pathology at Tokyo University Of Fisheries (1994) and Ph.D. on Immunology at Tokyo University Of Fisheries (1998). Current position working as assistant professor at School of Veterinary Medicine and Animal Science of the University of Sao Paulo. Research fields include immunology of reproduction in bovine, rats and mice, fish immunology and mainly mammary tumor immunology in dogs and women, with focus on the enzyme indoleamine 2, 3 dioxygenase - IDO immunomodulation as a tool for immunotherapy. Regarding our fish immunology studies, nowadays we are focusing on improving the efficiency of the germ cell xenotransplantation by using immunosuppressive agents. Techniques skills: monoclonal/polyclonal antibody production, flow cytometry, cell culture, etc. (Source: Lattes Curriculum)
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Nowadays immunotherapy is a popular therapy approach for cancer patients. Although recent progress in cancer immunotherapy has had a significant clinical outcome, not all patients successfully respond to this therapy. Hence, understanding the molecular mechanisms of cancer immunotherapy and anti-tumor immune escape is essential in order to develop more efficient therapies. It is demonstra…
The heterogeneity, flexibility and cellular plasticity support the hypothesis of the association of bioactive biomaterials, with stem cells and / or bioactive molecules, as an alternative in the reconstruction of tissue losses. It is a relevant public health problem, since grafts and transplants show clinical results that are not always satisfactory. On the one hand, the lack of organs an…
The heterogeneity, flexibility and cellular plasticity support the hypothesis of the association of bioactive biomaterials, with stem cells and / or bioactive molecules, as an alternative in the reconstruction of tissue losses. It is a relevant public health problem, since grafts and transplants show clinical results that are not always satisfactory. On the one hand, the lack of organs an…
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The enzyme indoleamine 2,3 dioxygenase - IDO plays an important role on the immune system regulation, impairing the development of an immune response in the microenvironment it is expressed. Its activation leads to tryptophan catabolism consequently depriving it to proliferating cells along with metabolites generation that induce these cells to apoptosis. It is known that steroidal reprod…
On daily small animal veterinary practice throughout the world, mammary cancer is widely recognized as the leading females affecting neoplasia of the canine species. Indoleamine 2,3 - dioxygenase (IDO) is an enzyme expressed by various cells and, among its many functions, works mainly in immune system regulation. This enzyme acts by inhibiting T lymphocytes proliferation by tryptophan cat…
Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the cataboiism of tryptophan and by limiting the offer of this essential amino acid, impairs proliferation of alloreactive T cells, thus helping preventing rejection of the conceptus during pregnancy. Several studies have been conducted on the role of IDO on maternal-fetal tolerance in human and murine placental tissue. Changes in…
Indoleamine - 2,3 - dioxygenase (IDO) is an enzyme that catabolizes tryptophan, an essential amino acid necessary for T cells proliferation, therefore compromising its activity (BARKSDALE et al., 2004). IDO is expressed by several types of cells, including monocytes-derived macrophages and dendritic cells (MUNN et al., 2004). Evaluating the presence of IDO in blood cells and organs of rai…
| 4 / 4 | Ongoing grants |
| 6 / 3 | Completed research grants |
| 6 / 2 | Completed scholarships in Brazil |
| 16 / 9 | All research grants and scholarships |
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