Claudio Miguel da Costa Neto
CV Lattes
GoogleMyCitations
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduation in Biological Sciences at the Universidade Federal de São Carlos (1992) and PhD in Biochemistry at Universidade Federal de São Paulo / University of Copenhagen, Denmark (1998). Has experience in Molecular Pharmacology, acting on the following subjects: GPCRs, Angiotensina II, 7TM receptors, mutagenesis, signal transduction, and drug discovery and development. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Biosensors make new approaches to drug discovery possible |
- São Paulo School of Advanced Science On Medicines: from Target to Market, AO.R.ESPCA
- Jillian Glenda Baker | University Nottingham - Inglaterra, AV.EXT
Abstract
The following activities are planned for JGB mission in Brazil in 2016:1) Discussions with CMC-N, students and post-doctoral trainees about the experimental guidelines and initial results of the Project; 2) Seminar presentation by JGB; 3) Organization of a Workshop about GPCR biased signalling. Based on the results obtained with this initial project, we plan for the end of 2016 to write...
- Development of biosensors for monitoring signaling in subcellular compartments: a powerful molecular tool for drug discovery, AP.R SPRINT
Abstract
G protein-coupled receptors (GPCRs) constitute the largest family of signal transducer proteins in mammals and are considered a major target for drug discovery. After stimulation, GPCRs activate G proteins and then recruit β- arrestins, which more recently has been shown to lead to G protein-independent signaling that can persist even in the internalized endosomes. Recent advances in GP...
(Only some records are available in English at this moment)
- Biochemical and pharmacological characterization of oxytocin forms in New World monkeys: activities on oxytocin and vasopressin receptors, BP.PD
Abstract
Oxytocin (OXT) and vasopressin (AVP) are neuropeptides, and their interaction with their receptors (OXTR, AVPR1a, AVPR1b and AVPR2) promotes physiological and behavioral functions. These receptors are part of the large family of G protein-coupled receptors (GPCRs); currently they are target about 40% of all drugs and medications on the market.Although oxytocin is very conserved in place...
- Space-time characterization of g protein-coupled receptors (GPCRs) signal transduction through new bioluminescence resonance energy transfer (BRET)-based biosensors, BP.PD
Abstract
The G protein-coupled receptor (GPCR) superfamily mediates the majority of the physiological processes and is target for approximately 40% of the drugs currently in the market. Despite the recent advances in the study of GPCR signaling, the role of lipid rafts in GPCRs signaling regulation is still not defined, probably due to the lack of accurate enough technologies to study lipid raft...
- Comparative analysis of the AT1 receptor signaling profile after activation by balanced and biased agonists by proteomic approach, BP.DR
Abstract
G-protein coupled receptors (GPCRs) are integral membrane proteins characterized as having seven transmembrane alpha-helices. These receptors are important targets for biomedical studies, and approximately 40% of the currently marketed drugs act on them. The angiotensin II type 1 (AT1) receptor is a GPCR, and the main receptor of the renin-angiotensin system (SRA), mediating important ...
- New ligands of angiotensin II AT1 receptor with non-canonical signaling pathways activation potential: large-scale development and characterization, BP.PD
Abstract
G-protein coupled receptors (GPCRs) are important pharmacological targets in all clinical areas, for controlling many physiological processes. Currently, around 50% of drugs on the market act directly or indirectly through GPCRs. Large pharmaceutical companies are looking for new ligands targeting these receptors that show potential as new medicines. Recently the literature has highligh...
- Identification of molecular partners from Angiotensin II receptor type 1 (AT1) involved with the activation of a new signaling pathway, BP.PD
Abstract
G-protein-coupled receptors (GPCRs) belong to a superfamily of integral membrane proteins which have in their structure seven transmembrane alpha-helices, and for that reason, they are also known as 7 transmembrane receptors (7TMRs). 7TMRs constitute the largest class of cell surface receptors and they regulate a wide range of physiological and pathological processes, because of that, 7...
(Only some records are available in English at this moment)
- Assessing the microdomain localization-dependent role of GPCRs and effectors on signal transduction using bioluminescence resonance energy transfer (BRET)-based biosensors, BE.EP.DR
Abstract
G protein-coupled receptors (GPCRs) are integral membrane proteins characterized by a topology of seven transmembrane ±-helices that mediate a large number of physiological processes after binding of a wide range of ligands. It has been shown that during signal transduction, dynamic changes can occur in the localization of receptor and effectors in plasma membrane microdomains and intra...
- Functional crosstalk between Mas and AT1 receptors addressed by BRET-based biosensors, BE.EP.PD
Abstract
G protein-coupled receptors (GPCRs) are physiologically important cell-surface proteins that sense signaling messengers such as hormones, photons and even mechanical stress, and are the targets of several prescribed drugs. An important therapeutic target in hypertension and congestive heart failure is the renin-angiotensin system (RAS). Angiotensin II (AngII), the main component of the ...
- Bioengineering new BRET-based biosensors to analyze GPCR signal transduction from different intracellular compartments, BE.EP.PD
Abstract
G protein-coupled receptors (GPCRs) constitute the largest family of signal transducer proteins in mammals and are considered a major target for drug discovery. After stimulation, GPCRs activate G proteins and then recruit ²-arrestins, which lead to disruption of G protein signaling and initiation of the internalization process. Although b-arrestin was first discovered for its role in i...
| 12 / 7 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 18 / 8 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 35 / 20 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 14 |
| Citations | 205 |
| Cit./Article | 14.6 |
| Data from Web of Science | |
TEIXEIRA, LARISSA B.; PARREIRAS-E-SILVA, LUCAS T.; BRUDER-NASCIMENTO, THIAGO; DUARTE, DIEGO A.; SIMOES, SARAH C.; COSTA, RAFAEL M.; RODRIGUEZ, DEISY Y.; FERREIRA, PEDRO A. B.; SILVA, CARLOS A. A.; ABRAO, EMILIANA P.; et al. Ang-(1-7) is an endogenous beta-arrestin-biased agonist of the AT(1) receptor with protective action in cardiac hypertrophy. SCIENTIFIC REPORTS, v. 7, SEP 19 2017. Web of Science Citations: 20. (13/08216-2, 15/50086-4, 12/20148-0)
PARREIRAS-E-SILVA, LUCAS T.; LUCHESSI, AUGUSTO D.; REIS, ROSANA I.; OLIVER, CONSTANCE; JAMUR, MARIA C.; RAMOS, RICARDO G. P.; OLIVEIRA, EDUARDO B.; CURI, RUI; COSTA-NETO, CLAUDIO M.. Evidences of a Role for Eukaryotic Translation Initiation Factor 5A (eIF5A) in Mouse Embryogenesis and Cell Differentiation. Journal of Cellular Physiology, v. 225, n. 2, p. 500-505, NOV 2010. Web of Science Citations: 14.
SOUZA, LAURA L.; COSTA-NETO, CLAUDIO M.. Angiotensin-(1-7) decreases LPS-induced inflammatory response in macrophages. Journal of Cellular Physiology, v. 227, n. 5, p. 2117-2122, MAY 2012. Web of Science Citations: 41.
PARREIRAS-E-SILVA, LUCAS T.; VARGAS-PINILLA, PEDRO; DUARTE, DIEGO A.; LONGO, DANAE; ESPINOZA PARDO, GRACE VIOLETA; FINKLER, ANDREA DULOR; PAIXAO-CORTES, VANESSA RODRIGUES; PARE, PAMELA; ROVARIS, DIEGO L.; OLIVEIRA, EDUARDO B.; et al. Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 114, n. 34, p. 9044-9049, AUG 22 2017. Web of Science Citations: 13. (15/50086-4, 12/20148-0)
CORREA, MICHELLE F.; BARBOSA, ALEFE J. R.; TEIXEIRA, LARISSA B.; DUARTE, DIEGO A.; SIMOES, SARAH C.; PARREIRAS-E-SILVA, LUCAS T.; BALBINO, ALEKSANDRO M.; LANDGRAF, RICHARDT G.; BOUVIER, MICHEL; COSTA-NETO, CLAUDIO M.; et al. Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H-3 and H-4 Receptors with Anti-inflammatory Potential. FRONTIERS IN PHARMACOLOGY, v. 8, NOV 14 2017. Web of Science Citations: 7. (16/23139-2, 13/20479-9, 16/25028-3, 12/20148-0, 17/02042-3)
MARIA, ANDREA G.; DILLENBURG-PILLA, PATRICIA; REIS, ROSANA I.; FLORIANO, ELAINE M.; TEFE-SILVA, CRISTIANE; RAMOS, SIMONE G.; PESQUERO, JOAO B.; NAHMIAS, CLARA; COSTA-NETO, CLAUDIO M.. Host kinin B1 receptor plays a protective role against melanoma progression. SCIENTIFIC REPORTS, v. 6, FEB 22 2016. Web of Science Citations: 0. (11/02144-4, 12/20148-0, 10/13346-4)
NAMKUNG, YOON; LEGOUILL, CHRISTIAN; KUMAR, SAHIL; CAO, YUBO; TEIXEIRA, LARISSA B.; LUKASHEVA, VIKTORIYA; GIUBILARO, JENNA; SIMOES, SARAH C.; LONGPRE, JEAN-MICHEL; DEVOST, DOMINIC; et al. Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors. Science Signaling, v. 11, n. 559, DEC 4 2018. Web of Science Citations: 7. (12/20148-0)
SILVA, RAFAELA R.; PARREIRAS-E-SILVA, LUCAS T.; POMPEU, THAIS E. T.; DUARTE, DIEGO A.; FRAGA, CARLOS A. M.; BARREIRO, ELIEZER J.; MENEGATTI, RICARDO; COSTA-NETO, CLAUDIO M.; NOEL, FRANCOIS. Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D-2 Receptor. FRONTIERS IN PHARMACOLOGY, v. 10, JUN 4 2019. Web of Science Citations: 0. (12/20148-0)
PEREIRA, MARILIA G. A. G.; BECARI, CHRISTIANE; OLIVEIRA, JOSE A. C.; SALGADO, MARIA CRISTINA O.; GARCIA-CAIRASCO, NORBERTO; COSTA-NETO, CLAUDIO M.. Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy. Clinical Science, v. 119, n. 11-12, p. 477-482, DEC 2010. Web of Science Citations: 38. (02/09406-5, 05/56447-7)
DILLENBURG-PILLA, PATRICIA; MARIA, ANDREA G.; REIS, ROSANA I.; FLORIANO, ELAINE MEDEIROS; PEREIRA, CACILDA DIAS; DE LUCCA, FERNANDO LUIZ; RAMOS, SIMONE GUSMAO; PESQUERO, JOAO B.; JASIULIONIS, MIRIAM G.; COSTA-NETO, CLAUDIO M.. Activation of the Kinin B1 Receptor Attenuates Melanoma Tumor Growth and Metastasis. PLoS One, v. 8, n. 5, MAY 17 2013. Web of Science Citations: 5. (10/13346-4)
COSTA-NETO, CLAUDIO M.; PARREIRAS-E-SILVA, LUCAS T.; BOUVIER, MICHEL. A Pluridimensional View of Biased Agonism. MOLECULAR PHARMACOLOGY, v. 90, n. 5, p. 587-595, NOV 1 2016. Web of Science Citations: 34. (15/50086-4, 12/20148-0)
MARIA, ANDREA GUTIERREZ; DILLEMBURG-PILLA, PATRICIA; DURAND, MARINA DE TOLEDO; FLORIANO, ELAINE MEDEIROS; MANFIOLLI, ADRIANA OLIVEIRA; RAMOS, SIMONE GUSMAO; PESQUERO, JOAO BOSCO; NAHMIAS, CLARA; COSTA-NETO, CLAUDIO M.. Activation of the Kinin B1 Receptor by Its Agonist Reduces Melanoma Metastasis by Playing a Dual Effect on Tumor Cells and Host Immune Response. FRONTIERS IN PHARMACOLOGY, v. 10, SEP 25 2019. Web of Science Citations: 0. (11/02144-4, 12/20148-0, 10/13346-4)
PEREIRA, MARILIA G. A. G.; BECARI, CHRISTIANE; OLIVEIRA, JOSE A. C.; SALGADO, MARIA CRISTINA O.; GARCIA-CAIRASCO, NORBERTO; COSTA-NETO, CLAUDIO M.. Inhibition of the renin-angiotensin system prevents seizures in a rat model of epilepsy. Clinical Science, v. 119, n. 11-12, p. 477-482, DEC 2010. Web of Science Citations: 38. (02/09406-5, 05/56447-7)
DILLENBURG-PILLA, PATRICIA; MARIA, ANDREA G.; REIS, ROSANA I.; FLORIANO, ELAINE MEDEIROS; PEREIRA, CACILDA DIAS; DE LUCCA, FERNANDO LUIZ; RAMOS, SIMONE GUSMAO; PESQUERO, JOAO B.; JASIULIONIS, MIRIAM G.; COSTA-NETO, CLAUDIO M.. Activation of the Kinin B1 Receptor Attenuates Melanoma Tumor Growth and Metastasis. PLoS One, v. 8, n. 5, MAY 17 2013. Web of Science Citations: 5. (10/13346-4)