CV Lattes
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Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de Guarulhos (1990) and doctorate at Imunologia from Instituto de Ciências Biomédicas - Departamento de Imunologia (2000). Has experience in General Biology, focusing on General Biology, acting on the following subjects: antissoro, acidentes, toxina recombiante, atividades tóxicas and anticorpos recombinantes. (Source: Lattes Curriculum)
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Neurodegenerative and demyelinating diseases are major global challenges due to the lack of therapies promoting functional Central Nervous System (CNS) regeneration. The internationally patented TnP peptide, derived from the Thalassophryne nattereri fish, is a promising neuroprotective and immunomodulatory molecule. However, advancing it to clinical trials requires bridging two critical g…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Inappropriate activation of TLR pathways by endogenous or exogenous ligands may lead to the initiation and/or perpetuation of autoimmune responses and tissue injury. Recently we identified in the venom of Thalassophryne nattereri a new class of proteases named Natterins. Using intravital microscopy we demonstrated the TLR antagonist effect of Natterins in venules of cremaster muscle of mi…
(Only some records are available in English at this moment)
Researchers at the Butantan Institute have identified the peptide TnP, extracted from the venom of the venomous fish Thalassophryne nattereri, with anti-inflammatory properties demonstrated in a murine model of multiple sclerosis (MS). Toxicological studies have shown that TnP, at concentrations between 1 nM and 10 µM, has no lethal or toxic effects in zebrafish (Danio rerio) larvae, a mo…
A edição gênica é uma ferramenta revolucionária que permite a modificação precisa de sequências de DNA em organismos vivos, com aplicações que vão desde a pesquisa básica até o desenvolvimento de terapias genéticas. A tecnologia CRISPR/Cas9, um dos métodos mais populares, utiliza um RNA guia para direcionar a nuclease Cas9 a uma sequência específica no genoma, promovendo cortes de fita du…
Zebrafish is a robust model for the study of eye diseases, surpassing murine models because it presents anatomical and functional similarities with human eye tissue. In addition, it presents rapid embryonic development, ease of genetic manipulation and retinal regeneration capacity. Hypoxic/Degenerative Retinopathies cause vision loss and therefore represent a serious problem in public he…
The mission of the Platforma Zebrafish of the Butantan Institute - Applied Toxinology Laboratory is to use toxins as molecular tools for the study of regulatory mechanisms that control inflammation. In the Immune Regulation Unit, the study of venomous fish had started and a new family of Natterine toxins was discovered, as well as the novel TnP peptide with anti-inflammatory activity from…
(Only some records are available in English at this moment)
The project focuses on exploring the therapeutic potential of the TnP family, derived from the venom of the Brazilian fish Thalassophryne nattereri, particularly in the context of retinopathy. This family comprises synthetic peptides with immunomodulatory properties, as demonstrated in studies using murine models of Multiple Sclerosis (EAE). Research has shown that TnP, administered subcu…
Our group identified in the venom of the fish Thalassophryne nattereri a novel cyclic peptide, TnP, in a preclinical development stage indicated for chronic inflammatory diseases such as asthma and multiple sclerosis. Recent data show its valuable potential as a safe anti-inflammatory drug due to its ability to control the traffic and activation of leukocytes in response to inflammation. …