CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade de Guarulhos (1990) and doctorate at Imunologia from Instituto de Ciências Biomédicas - Departamento de Imunologia (2000). Has experience in General Biology, focusing on General Biology, acting on the following subjects: antissoro, acidentes, toxina recombiante, atividades tóxicas and anticorpos recombinantes. (Source: Lattes Curriculum)
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Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
The aim of the Interinstitutional Center for Applied Toxinology is to establish a world-class center for research into natural toxins. The Center will develop the study of toxins with the aim to investigate their potential therapeutic use, to foster contacts between science and industry and to raise the level of scientific human resources. The Institute Butantan with its history and tradi…
Zebrafish is a robust model for the study of eye diseases, surpassing murine models because it presents anatomical and functional similarities with human eye tissue. In addition, it presents rapid embryonic development, ease of genetic manipulation and retinal regeneration capacity. Hypoxic/Degenerative Retinopathies cause vision loss and therefore represent a serious problem in public he…
The mission of the Platforma Zebrafish of the Butantan Institute - Applied Toxinology Laboratory is to use toxins as molecular tools for the study of regulatory mechanisms that control inflammation. In the Immune Regulation Unit, the study of venomous fish had started and a new family of Natterine toxins was discovered, as well as the novel TnP peptide with anti-inflammatory activity from…
Studies developed previously by our group show that the venom of Thalassophryne nattereri venomous fish develops an inappropriate cellular inflammatory response characterized by a reduced number of leukocytes at the site of injury. As from a combined proteomic and transcriptomic approaches the composition of T. nattereri venom was studied and the majority proteins present in the venom of …
The poison of venomous fish Thalassophryne nattereri consists of proteins endowed with proteolytic, myotoxic properties and without phospholipase activity. Regarding inflammatory action, the T. nattereri poison demonstrate that after its injection in mice, there is a significant release of inflammatory cytokines such as TNF±, IL1² and IL6, however accompanied by a poor cellular inflammato…
Immunity is the reaction to foreign substances of any type, as feedback mechanisms having components of both innate immune response(phagocyte cells , physical, biochemical barriers, natural killer cells and blood protein constituents) that have receptors that recognize conserved structures, such as leukocyte components of the adaptive immune system or specific. The Thalassophryne natterer…
(Only some records are available in English at this moment)
The project focuses on exploring the therapeutic potential of the TnP family, derived from the venom of the Brazilian fish Thalassophryne nattereri, particularly in the context of retinopathy. This family comprises synthetic peptides with immunomodulatory properties, as demonstrated in studies using murine models of Multiple Sclerosis (EAE). Research has shown that TnP, administered subcu…
Our group identified in the venom of the fish Thalassophryne nattereri a novel cyclic peptide, TnP, in a preclinical development stage indicated for chronic inflammatory diseases such as asthma and multiple sclerosis. Recent data show its valuable potential as a safe anti-inflammatory drug due to its ability to control the traffic and activation of leukocytes in response to inflammation. …
| 1 / 1 | Ongoing research grants |
| 4 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 20 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 30 / 12 | All research grants and scholarships |
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