CV Lattes
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ORCID
Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduate at Química from Universidade Estadual Paulista Júlio de Mesquita Filho (1996), master's at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1999) and Ph.D. at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (2003). Has experience in Chemistry, focusing on Fields of Coordination, acting on the following subjects: amino acids, metals in medicine and bioinorganic chemistry . (Source: Lattes Curriculum)
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Cancer is a major public health problem worldwide and ranks among the leading causes of death. Identifying new agents for the diagnosis and treatment of patients with cancer is highly desirable. For many centuries, metals have been used empirically to treat various diseases. Nowadays, metals and their compounds - stable or radioactive - are rationally applied in both the diagnosis and tre…
Ovarian cancer is one of the most common in women. Depending on the patient's conditions, the treatment may include surgery, radiotherapy, immunotherapy and chemotherapy, the last one including platinum(II) complexes such as cisplatin. However, platinum drugs present limitations during treatment, such as development of resistance and adverse effects. For this reason, the search for new an…
Several diseases caused by bacteria of different species, as well as those caused by some types of viruses, such as influenza and dengue, are a case of concern. Epidemiological data estimate 3 to 5 million cases of influenza per year and approximately 290 to 650 thousand deaths. The symptoms caused by severe cases of influenza are similar to the symptoms caused by dengue fever, which is a…
The discovery and the rational use of antimicrobial agents in the treatment of several infections brought a significant improvement in the life quality of patients. However, the indiscriminate use antimicrobial agents, including sulfonamides, has led to the appearance of multi-resistant bacterial strains, leading to the search for new drugs. One of the strategies to develop new antibacter…
(Only some records are available in English at this moment)
The emergence of a large number of new cases, as well as cellular resistance to multiple drugs, have been a challenge in the fight against several types of cancer. One of the strategies to overcome this challenge is the development of new drugs that combine drugs currently available in the clinic (or under clinical tests) and metals with recognized cytotoxic activities. Uracil derivatives…
The growing incidence of cancer, as well as its greater resistance to traditional treatments, such as the use of cisplatin, has given great relevance to the search of new forms of treatment for this disease. The modification of existing drugs to increase their efficiency, as well as their combination with other active species, have shown to be effective methods and reported in the literat…
The growing demand for new alternatives in the treatment of infectious diseases makes the search for new drugs with antiviral properties extremely important. Modifying existing drugs or combining them with other species that are equally active on microorganisms is a good strategy for obtaining new agents with potential clinical use. Amantadine, memantine and rimantadine are drugs from the…
Bacterial infections constitute a public health case of concern. The high frequency of these diseases is primarily caused by the lack of appropriate treatment of infections or the emergence of multidrug-resistant strains. Meanwhile, the search of alternatives for the treatment of skin tumours is also growing worldwide, as the primary treatment for this disease is surgical resection, which…
Squamous cell carcinoma of the skin (SCC) is one of the most prevalent tumors in humans, being classified as the second most common type of skin cancer. This type of tumor originates from the keratinocytes of the basal layer of the epidermis and usually manifests itself in areas of the body that are more exposed to the sun, such as the ears, face, nose, and neck. The treatments used for S…
The growing demand for new alternatives in the treatment of infectious diseases makes the search for new drugs with antibacterial, antifungal, and antiviral action extremely important. The modification of existing drugs or their combination with other species active on microorganisms is an interesting strategy to obtain new molecules with the potential for clinical use. Amantadine and mem…
(Only some records are available in English at this moment)
Bacterial infections remain a significant public health concern, due to the high incidence of these diseases and the growing challenge of multidrug-resistant bacterial strains. The lack of effective treatment options contributes to the persistence of these infections. At the same time, there is an increasing global focus on finding alternatives for treating skin tumours, as surgical remov…
Nucleobases are molecules considered as basic building blocks of DNA and RNA nucleic acids. When some part is chemically modified, they become known as nucleobase analogues, such as 2-thiouracil (2TU), 2,4-dithiouracil (2,4DTU) and 6-trifluorometiluracil (6-TFMU). Recent studies showed that when coordinated to metal ions like copper(II) and silver(II), their antitumoral, antiviral and ant…
Aminoadamantanes, such as amantadine, memantine and rimantadine, are molecules obtained from the functionalization of adamantane that present pharmacological activities. Amantadine and rimantadine are used as agents in the prevention and treatment of Influenza A virus infections, while memantine is used in medicine to treat neurodegenerative conditions such as Alzheimer's disease. Recent …
Polynuclear platinum(II) complexes are promising chemotypes for the development of new anticancer agents with distinct mechanisms of action when compared to cisplatin-derived mononuclear complexes. Triplatin BBR3464 is a successful polynuclear Pt(II) complex, the only non-cisplatin analog to reach Phase II human clinical trials. However, pharmacokinetic issues derived from thiol nucleophi…
| 1 / 1 | Ongoing grants |
| 7 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 25 / 19 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 40 / 33 | All research grants and scholarships |
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