Graduate in Biological Sciences from Universidade Federal de Minas Gerais (1998), Master degree at Biochemistry from Universidade Federal de Minas Gerais (2000) and Ph.D. in Biochemistry from Universidade Federal de Minas Gerais (2002). Post-doctoral fellow in School of Medicine of São José do Rio Preto, Brasil (2003-2006), National Institute of Health (Bethesda, MD) (2006), and Virginia Commonwealth University, Richmond, USA (2015-2016). Associate Professor at the University of São Paulo. Has expertise in Biochemistry and Genetics, focusing on Biochemistry and Molecular Biology, acting on the following subjects: cancer, molecular biology, molecular oncology, human and medical genetics, sphingolipids, cellular signaling. (Source: Lattes Curriculum)
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Despite the reached breakthrough in the treatment of some cancer types, the search for new therapeutic targets and antitumor therapy strategies to overcome tumor metastases, relapse, and resistance to therapy, is required. The present research proposal aims to identify evidences on the role of SET protein regarding sphingolipid signaling pathway, as well as the sphingolipids role, in head…
As one of the subtypes of head and neck cancer (PBC), the oral squamous cell carcinoma, is the head and neck cancer more common and is strongly associated with use of tobacco and alcohol. The multifunctional protein SET is an oncoprotein involved in the regulation of apoptosis, transcription, besides being a subunit complex that inhibits histone acetylation by binding to and masking histo…
The boarding of this project is that used during the post doc in the exterior in the National Institute of Health (NIH, U.S.A.) (FAPESP process: 05/03380-2) and it constitutes a new line of research to be implanted and to be established in the Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP. The central objective is the protein study selected as markers tumoral using functional …
Sphingosine-1-phosphate (S1P), a bioactive sphingolipid, is produced by sphingosine kinase 1 (SK1) and SK2 and acts through paracrine, autocrine and intracellular signaling pathways. Changes in S1P levels, SK1 and SK2 enzymes, as well as S1P receptors, have been described in cancer. Furthermore, S1P have also been recognized as important cellular mediator in hypoxia and angiogenesis. Hypo…
Head and neck squamous cell carcinoma (HNSCC) has high incidence and recurrence rates. In addition to genomic alterations, epigenetics, such as dysregulation of microRNAs (miRNAs), also occur in HNSCC. Recently, our research group characterized the relationship of sphingolipids and sphingosine kinase 2 (SK2) with oral squamous cancer. Furthermore, the RNA sequence data showed the deregula…
Squamous cell carcinoma of the oral cavity (OSCC) is a malignant tumor and the main cause of morbidity and mortality among all cancers of the head and neck. It is an immunosuppressive disease, metastatic and highly resistant to conventional treatments. Recent studies have identified that biomolecules of the metabolic pathway of sphingolipids (SPs) are involved in the immunoregulation of t…
(Only some records are available in English at this moment)
Heterogeneous ribonucleoprotein K (hnRNPK) has been described as increased in many cancers, including in oral cancer, and associated with their worse prognosis. This protein binds toRNA and DNA and participates in different regulatory protein-protein interactions, being found in the nucleus, cytosol and mitochondria. HnRNPK protein is the target of a series of post-translational modificat…
(Only some records are available in English at this moment)
Squamous cell carcinoma of the oral cavity (OSCC) is a malignant tumor and the leading cause of mortality among all head and neck cancers. It is an immunosuppressive disease, metastatic, and resistant to conventional immune-based therapies. Thus, there is a critical need for more effective immunotherapies for OSCC. Recent studies have demonstrated that the Sigma-1 Receptor (Sig-1R), a bio…
This proposal will provide evidence that the SphK1/S1P/S1PR1 axis is one of the critical factors that bridge obesity, inflammation, and hepatocellular carcinoma (HCC)[1-5]. Surgical procedures such as liver resection and liver transplantation are the first-line treatments for HCC patients. However, the high incidence of tumor recurrence and metastasis after liver surgery remains a major p…
Cancer is the second cause of death in Brazil and the oral cancer is among the most predominant cancers worldwide. During tumorigenesis several changes occur in the genome, transcriptome, proteome and interatoma leading to malignant cells development. Some of the more important modifications occur in the PI3K-AKT pathway, such as the loss of PTEN phosphatase function, which increase PtdIn…
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancy worldwide, representing a major international health problem. Patients in early stages frequently exhibit few symptoms, resulting in diagnosis delay and decrease in survival. Unfortunately, despite intense research and improvements in early detection and therapeutic strategies, the prediction of tumor behav…
| 1 / 1 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 19 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 31 / 27 | All research grants and scholarships |
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CV Lattes
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