CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate in Biological Sciences from Universidade Federal de Minas Gerais (1998), Master degree at Biochemistry from Universidade Federal de Minas Gerais (2000) and Ph.D. in Biochemistry from Universidade Federal de Minas Gerais (2002). Post-doctoral fellow in School of Medicine of São José do Rio Preto, Brasil (2003-2006), National Institute of Health (Bethesda, MD) (2006), and Virginia Commonwealth University, Richmond, USA (2015-2016). Associate Professor at the University of São Paulo. Has expertise in Biochemistry and Genetics, focusing on Biochemistry and Molecular Biology, acting on the following subjects: cancer, molecular biology, molecular oncology, human and medical genetics, sphingolipids, cellular signaling. (Source: Lattes Curriculum)
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Despite the reached breakthrough in the treatment of some cancer types, the search for new therapeutic targets and antitumor therapy strategies to overcome tumor metastases, relapse, and resistance to therapy, is required. The present research proposal aims to identify evidences on the role of SET protein regarding sphingolipid signaling pathway, as well as the sphingolipids role, in head…
As one of the subtypes of head and neck cancer (PBC), the oral squamous cell carcinoma, is the head and neck cancer more common and is strongly associated with use of tobacco and alcohol. The multifunctional protein SET is an oncoprotein involved in the regulation of apoptosis, transcription, besides being a subunit complex that inhibits histone acetylation by binding to and masking histo…
The boarding of this project is that used during the post doc in the exterior in the National Institute of Health (NIH, U.S.A.) (FAPESP process: 05/03380-2) and it constitutes a new line of research to be implanted and to be established in the Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP. The central objective is the protein study selected as markers tumoral using functional …
Cancer biomarkers discovery are essential for diagnosis, prognosis and personalized cancer therapy personalized cancer therapy. The oral cancer is a worldwide health problem with high recurrence and mortality. In Brazil, there are about 15,000 new cases estimated for 2020. Diagnosis, prognosis and treatment are still currently performed based on traditional staging, without the applicatio…
Despite the breakthrough in treating some cancers, the search for new therapeutic targets and antitumor therapy to prevent metastasis, relapse and resistance to therapy is needed. The present thematic proposal aims to define the role of the SET protein in the signaling pathway of sphingolipids, as well as their role in head and neck squamous cell carcinoma (HNSCC). Numerous experimental a…
Heterogeneous ribonucleoprotein K (hnRNPK) has been described as increased in many cancers, including in oral cancer, and associated with their worse prognosis. This protein binds toRNA and DNA and participates in different regulatory protein-protein interactions, being found in the nucleus, cytosol and mitochondria. HnRNPK protein is the target of a series of post-translational modificat…
Despite the breakthrough in the treatment of some types of Cancer, the search for new therapeutic targets and antitumor therapy strategies to prevent metastasis, relapse and resistance to therapy is mandatory. The present proposal aims to define the role of sphingosine kinase 2 and SET in signaling by sphingolipids in oral Cancer. We will carry out studies on human cell derived from tumor…
Sphingolipids are a class of essential lipids in eukaryotes not only by composing the plasma membrane but because they are bioactive molecules. Thus, they are involved in the regulation of many cellular processes and different types of signaling. Among the diversity of pathways that sphingolipids are associated with are included cell proliferation, apoptosis, senescence, angiogenesis, end…
(Only some records are available in English at this moment)
This proposal will provide evidence that the SphK1/S1P/S1PR1 axis is one of the critical factors that bridge obesity, inflammation, and hepatocellular carcinoma (HCC)[1-5]. Surgical procedures such as liver resection and liver transplantation are the first-line treatments for HCC patients. However, the high incidence of tumor recurrence and metastasis after liver surgery remains a major p…
Cancer is the second cause of death in Brazil and the oral cancer is among the most predominant cancers worldwide. During tumorigenesis several changes occur in the genome, transcriptome, proteome and interatoma leading to malignant cells development. Some of the more important modifications occur in the PI3K-AKT pathway, such as the loss of PTEN phosphatase function, which increase PtdIn…
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancy worldwide, representing a major international health problem. Patients in early stages frequently exhibit few symptoms, resulting in diagnosis delay and decrease in survival. Unfortunately, despite intense research and improvements in early detection and therapeutic strategies, the prediction of tumor behav…
| 1 / 1 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 16 / 13 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 26 / 22 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 18 |
| Citations | 118 |
| Cit./Article | 6.6 |
| Data from Web of Science | |
ALMEIDA, LUCIANA O.; NETO, MARINALDO P. C.; SOUSA, LUCAS O.; TANNOUS, MARYNA A.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. ONCOTARGET, v. 8, n. 16, p. 26802-26818, APR 18 2017. Web of Science Citations: 6. (13/08135-2, 09/52228-0, 13/10898-4, 10/20384-0, 10/20536-4, 09/10783-7)
SOBRAL, LAYS M.; COLETTA, RICARDO D.; ALBERICI, LUCIANE C.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line. FEBS Journal, v. 284, n. 17, p. 2774-2785, SEP 2017. Web of Science Citations: 4. (13/08135-2, 10/18544-9, 13/10898-4)
PADOVANI, KARINA STRINGHETTA; GOTO, RENATA NISHIDA; FUGIO, LAIS BRIGLIADORI; GARCIA, CRISTIANA BERNADELLI; ALVES, VANI MARIA; BRASSESCO, MARIA SOL; GREENE, LEWIS JOEL; REGO, EDUARDO MAGALHAES; LEOPOLDINO, ANDREIA MACHADO. Crosstalk between hnRNP K and SET in ATRA-induced differentiation in acute promyelocytic leukemia. FEBS OPEN BIO, v. 11, n. 7, p. 2019-2032, JUL 2021. Web of Science Citations: 0. (13/01355-7, 13/00374-8, 13/10898-4, 13/08135-2, 16/19103-2)
FUGIO, LAIS BRIGLIADORI; COELI-LACCHINI, FERNANDA B.; LEOPOLDINO, ANDREIA MACHADO. Sphingolipids and Mitochondrial Dynamic. CELLS, v. 9, n. 3, MAR 2020. Web of Science Citations: 0. (18/14225-8, 16/19103-2, 13/08135-2)
LEOPOLDINO, ANDREIA MACHADO; CANDURI, FERNANDA; CABRAL, HAMILTON; JUNQUEIRA, MAGNO; MARQUI, ALESSANDRA BERNADETE TROVÓ DE; APPONI, LUCIANO H.; FONSECA, ISABEL OSÓRIO DA; DOMONT, GILBERTO BARBOSA; SANTOS, DIÓGENES S.; VALENTINI, SANDRO; et al. Expression, purification, and circular dichroism analysis of human CDK9. Protein Expression and Purification, v. 47, n. 2, p. 614-620, June 2006. (01/07532-0)
SOBRAL, LAYS M.; SOUSA, LUCAS O.; COLETTA, RICARDO D.; CABRAL, HAMILTON; GREENE, LEWIS J.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Molecular Cancer, v. 13, FEB 20 2014. Web of Science Citations: 26. (13/08135-2, 09/52228-0, 13/10898-4, 10/20384-0, 10/18544-9)
LEOPOLDINO, ANDREIA M.; SQUARIZE, CRISTIANE H.; GARCIA, CRISTIANA B.; ALMEIDA, LUCIANA O.; PESTANA, CEZAR R.; SOBRAL, LAYS M.; UYEMURA, SERGIO A.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS. SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncology, v. 48, n. 11, p. 1106-1113, NOV 2012. Web of Science Citations: 23. (09/52228-0, 05/03380-2, 06/06334-4, 10/20384-0)
ALMEIDA, LUCIANA O.; GARCIA, CRISTIANA B.; MATOS-SILVA, FLAVIA A.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation. Biochemical and Biophysical Research Communications, v. 445, n. 1, p. 196-202, FEB 28 2014. Web of Science Citations: 9. (09/52228-0, 07/02223-6, 13/10898-4, 10/20384-0, 09/10783-7)
ALMEIDA, LUCIANA O.; GOTO, RENATA N.; NETO, MARINALDO P. C.; SOUSA, LUCAS O.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario. Biochemical and Biophysical Research Communications, v. 458, n. 2, p. 300-306, MAR 6 2015. Web of Science Citations: 5. (09/52228-0, 13/10898-4, 10/20384-0, 13/01355-7, 09/10783-7)
FAEDO, RAQUEL ROMAN; DA SILVA, GABRIEL; DA SILVA, RODRIGO MOREIRA; USHIDA, TATIANE RESENDE; DA SILVA, RICARDO ROBERTO; LACCHINI, RICCARDO; MATOS, LEANDRO LUONGO; KOWALSKI, LUIZ PAULO; LOPES, NOBERTO PEPORINE; LEOPOLDINO, ANDREIA MACHADO. Sphingolipids signature in plasma and tissue as diagnostic and prognostic tools in oral squamous cell carcinoma. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1867, n. 1, JAN 2022. Web of Science Citations: 0. (18/17480-9, 19/05026-4, 17/18922-2, 18/03278-3, 16/19103-2)
ALMEIDA, LUCIANA O.; NETO, MARINALDO P. C.; SOUSA, LUCAS O.; TANNOUS, MARYNA A.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. ONCOTARGET, v. 8, n. 16, p. 26802-26818, APR 18 2017. Web of Science Citations: 6. (13/08135-2, 09/52228-0, 13/10898-4, 10/20384-0, 10/20536-4, 09/10783-7)
SOBRAL, LAYS M.; COLETTA, RICARDO D.; ALBERICI, LUCIANE C.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line. FEBS Journal, v. 284, n. 17, p. 2774-2785, SEP 2017. Web of Science Citations: 4. (13/08135-2, 10/18544-9, 13/10898-4)
PADOVANI, KARINA STRINGHETTA; GOTO, RENATA NISHIDA; FUGIO, LAIS BRIGLIADORI; GARCIA, CRISTIANA BERNADELLI; ALVES, VANI MARIA; BRASSESCO, MARIA SOL; GREENE, LEWIS JOEL; REGO, EDUARDO MAGALHAES; LEOPOLDINO, ANDREIA MACHADO. Crosstalk between hnRNP K and SET in ATRA-induced differentiation in acute promyelocytic leukemia. FEBS OPEN BIO, v. 11, n. 7, p. 2019-2032, JUL 2021. Web of Science Citations: 0. (13/01355-7, 13/00374-8, 13/10898-4, 13/08135-2, 16/19103-2)
FUGIO, LAIS BRIGLIADORI; COELI-LACCHINI, FERNANDA B.; LEOPOLDINO, ANDREIA MACHADO. Sphingolipids and Mitochondrial Dynamic. CELLS, v. 9, n. 3, MAR 2020. Web of Science Citations: 0. (18/14225-8, 16/19103-2, 13/08135-2)
LEOPOLDINO, ANDREIA MACHADO; CANDURI, FERNANDA; CABRAL, HAMILTON; JUNQUEIRA, MAGNO; MARQUI, ALESSANDRA BERNADETE TROVÓ DE; APPONI, LUCIANO H.; FONSECA, ISABEL OSÓRIO DA; DOMONT, GILBERTO BARBOSA; SANTOS, DIÓGENES S.; VALENTINI, SANDRO; et al. Expression, purification, and circular dichroism analysis of human CDK9. Protein Expression and Purification, v. 47, n. 2, p. 614-620, June 2006. (01/07532-0)
SOBRAL, LAYS M.; SOUSA, LUCAS O.; COLETTA, RICARDO D.; CABRAL, HAMILTON; GREENE, LEWIS J.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Molecular Cancer, v. 13, FEB 20 2014. Web of Science Citations: 26. (13/08135-2, 09/52228-0, 13/10898-4, 10/20384-0, 10/18544-9)
LEOPOLDINO, ANDREIA M.; SQUARIZE, CRISTIANE H.; GARCIA, CRISTIANA B.; ALMEIDA, LUCIANA O.; PESTANA, CEZAR R.; SOBRAL, LAYS M.; UYEMURA, SERGIO A.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS. SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncology, v. 48, n. 11, p. 1106-1113, NOV 2012. Web of Science Citations: 23. (09/52228-0, 05/03380-2, 06/06334-4, 10/20384-0)
ALMEIDA, LUCIANA O.; GARCIA, CRISTIANA B.; MATOS-SILVA, FLAVIA A.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation. Biochemical and Biophysical Research Communications, v. 445, n. 1, p. 196-202, FEB 28 2014. Web of Science Citations: 9. (09/52228-0, 07/02223-6, 13/10898-4, 10/20384-0, 09/10783-7)
ALMEIDA, LUCIANA O.; GOTO, RENATA N.; NETO, MARINALDO P. C.; SOUSA, LUCAS O.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario. Biochemical and Biophysical Research Communications, v. 458, n. 2, p. 300-306, MAR 6 2015. Web of Science Citations: 5. (09/52228-0, 13/10898-4, 10/20384-0, 13/01355-7, 09/10783-7)
FAEDO, RAQUEL ROMAN; DA SILVA, GABRIEL; DA SILVA, RODRIGO MOREIRA; USHIDA, TATIANE RESENDE; DA SILVA, RICARDO ROBERTO; LACCHINI, RICCARDO; MATOS, LEANDRO LUONGO; KOWALSKI, LUIZ PAULO; LOPES, NOBERTO PEPORINE; LEOPOLDINO, ANDREIA MACHADO. Sphingolipids signature in plasma and tissue as diagnostic and prognostic tools in oral squamous cell carcinoma. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, v. 1867, n. 1, JAN 2022. Web of Science Citations: 0. (18/17480-9, 19/05026-4, 17/18922-2, 18/03278-3, 16/19103-2)
(References retrieved automatically from State of São Paulo Research Institutions)
TANNOUS, Maryna Aguilar. O papel da proteína SET no perfil de metilação do miR-9 e no reparo de DNA em células humanas de carcinoma espinocelular oral. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (12/12928-5)
PADOVANI, Karina Stringhetta. Análise da proteína hnRNP K nas linhagens celulares NB4 e NB4-R2 de leucemia promielocítica aguda com ênfase na patogênese e na diferenciação celular pelo ácido all-trans retinoico. Tese (Doutorado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (13/00374-8)
MATSUMOTO, Camila Sayuri. Potenciais mecanismos de regulação da fosfatase PTEN pelas proteínas SET e PP2A e seu envolvimento na predisposição ao carcinoma bucal. Tese (Doutorado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (10/17985-1)
SILVA, Flávia Amoroso Matos e. Estudos das proteínas hnRNP K, SET e MARK3 como potenciais marcadores de prognóstico em câncer epidermóide de cabeça e pescoço (HNSCC). Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (07/02223-6)
GOTO, Renata Nishida. Estudo in vitro e in vivo de novos compostos: com alvo-específico (hnRNP K e SET) ou com ação na mitocôndria para uso como antitumoral em carcinoma oral ou como citoprotetor em célula não-tumoral. Tese (Doutorado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (13/01355-7)