Graduate in Biological Sciences from Universidade Federal de Minas Gerais (1998), Master degree at Biochemistry from Universidade Federal de Minas Gerais (2000) and Ph.D. in Biochemistry from Universidade Federal de Minas Gerais (2002). Post-doctoral fellow in School of Medicine of São José do Rio Preto, Brasil (2003-2006), National Institute of Health (Bethesda, MD) (2006), and Virginia Commonwealth University, Richmond, USA (2015-2016). Associate Professor at the University of São Paulo. Has expertise in Biochemistry and Human and Medical Genetics, focusing on Cellular and Molecular Biology, acting on the following subjects: cancer, molecular biology, molecular oncology, human and medical genetics, sphingolipids, cellular signaling, and therapeutic target. (Source: Lattes Curriculum)
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Oral squamous cell carcinoma (OSCC) is the most common subtype of head and neck cancer, with late diagnosis in advanced stages, often metastasizing to cervical lymph nodes, and with a high rate of disease recurrence. Despite advances in therapy and increased knowledge about risk factors associated with OSCC, the survival rate for patients has not improved substantially in the last few yea…
Despite the reached breakthrough in the treatment of some cancer types, the search for new therapeutic targets and antitumor therapy strategies to overcome tumor metastases, relapse, and resistance to therapy, is required. The present research proposal aims to identify evidences on the role of SET protein regarding sphingolipid signaling pathway, as well as the sphingolipids role, in head…
As one of the subtypes of head and neck cancer (PBC), the oral squamous cell carcinoma, is the head and neck cancer more common and is strongly associated with use of tobacco and alcohol. The multifunctional protein SET is an oncoprotein involved in the regulation of apoptosis, transcription, besides being a subunit complex that inhibits histone acetylation by binding to and masking histo…
The boarding of this project is that used during the post doc in the exterior in the National Institute of Health (NIH, U.S.A.) (FAPESP process: 05/03380-2) and it constitutes a new line of research to be implanted and to be established in the Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP. The central objective is the protein study selected as markers tumoral using functional …
Cancer, as one of the leading causes of global mortality, demands highly effective therapeutic approaches and the identification of highly specific biomarkers for accurate diagnosis and prognosis. In this context, sphingolipids emerge as key players due to their implications in the cancer landscape. Ceramide, a well-known sphingolipid with anti-tumoral properties, takes a prominent role. …
Head and neck squamous cell carcinoma (HNSCC) is a group of neoplasms that develop in the epithelia of the oral cavity, pharynx and larynx. These are tumors with high incidence rates, mainly in the Southeast region of Brazil, and more than 50%of diagnoses occur in advanced stages. Smoking and consumption of alcohol are among the main factors and together with papilloma virus infection (HP…
Intercellular communication is a key point in the polarization of macrophages towards the M1 and M2 subtypes. The M1 subtype has a pro-inflammatory profile while the M2 does not. Among the various changes that occur in cells and in the tumor microenvironment, we highlight the deregulation of sphingolipids. Recently, our group showed that the increase of sphingosine kinase 2 (SPHK2) in non…
(Only some records are available in English at this moment)
Oral squamous cell carcinoma (OSCC) is a highly invasive and metastatic tumor, resistant to current multimodal therapies, mirroring therapeutic failure. Therefore, a better understanding of CEO biogenesis's molecular mechanisms is necessary. It is known that the biomolecules of the sphingolipid (SPs) metabolic pathway, such as sphingosine kinases 2 (SK2) and sphingosines-1-phosphate (S1P)…
(Only some records are available in English at this moment)
Late stage of oral squamous cell carcinoma (OSCC) is characterized by metastasis and high mortality rates. Cancer-associated fibroblasts (CAFs), especially the alpha smooth muscle actin positive subtype exert crucial influences on OSCC progression and metastasis through complex signaling pathways. However, the molecular mechanisms underlying CAF-induced OSCC progression and metastasis rem…
O Carcinoma Espinocelular de Cabeça e Pescoço (CECP) é o sexto câncer mais comum no mundo, sendo responsável por muitas mortes devido a falhas de terapias e recorrências. Alterações no metabolismo dos esfingolipídeos, causadas pela desregulação da esfingosina quinase 2 (SK2) e agregação de p53, estão relacionadas à progressão do tumor. Nossa hipótese é que a conformação/agregação de p53 p…
Squamous cell carcinoma of the oral cavity (OSCC) is a malignant tumor and the leading cause of mortality among all head and neck cancers. It is an immunosuppressive disease, metastatic, and resistant to conventional immune-based therapies. Thus, there is a critical need for more effective immunotherapies for OSCC. Recent studies have demonstrated that the Sigma-1 Receptor (Sig-1R), a bio…
This proposal will provide evidence that the SphK1/S1P/S1PR1 axis is one of the critical factors that bridge obesity, inflammation, and hepatocellular carcinoma (HCC)[1-5]. Surgical procedures such as liver resection and liver transplantation are the first-line treatments for HCC patients. However, the high incidence of tumor recurrence and metastasis after liver surgery remains a major p…
Cancer is the second cause of death in Brazil and the oral cancer is among the most predominant cancers worldwide. During tumorigenesis several changes occur in the genome, transcriptome, proteome and interatoma leading to malignant cells development. Some of the more important modifications occur in the PI3K-AKT pathway, such as the loss of PTEN phosphatase function, which increase PtdIn…
(Only some records are available in English at this moment)
| 2 / 1 | Ongoing grants |
| 4 / 3 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 25 / 22 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 42 / 37 | All research grants and scholarships |
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