Andréia Machado Leopoldino
CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate in Biological Sciences from Universidade Federal de Minas Gerais (1998), Master degree at Biochemistry from Universidade Federal de Minas Gerais (2000) and Ph.D. in Biochemistry from Universidade Federal de Minas Gerais (2002). Post-doctoral fellow in School of Medicine of São José do Rio Preto, Brasil (2003-2006), National Institute of Health (Bethesda, MD) (2006), and Virginia Commonwealth University, Richmond, USA (2015-2016). Associate Professor at the University of São Paulo. Has expertise in Biochemistry and Genetics, focusing on Biochemistry and Molecular Biology, acting on the following subjects: cancer, molecular biology, molecular oncology, human and medical genetics, sphingolipids, cellular signaling. (Source: Lattes Curriculum)
- SET and sphingolipids in head and neck squamous cell carcinoma: signaling, targets and antiumoral therapy, AP.TEM
Abstract
Despite the reached breakthrough in the treatment of some cancer types, the search for new therapeutic targets and antitumor therapy strategies to overcome tumor metastases, relapse, and resistance to therapy, is required. The present research proposal aims to identify evidences on the role of SET protein regarding sphingolipid signaling pathway, as well as the sphingolipids role, in he...
- Identification of genes, miRNAs and proteins regulated by set oncoprotein and associated on malignization and tumor progression in HNSCC using in vitro and in vivo models, AP.R
Abstract
As one of the subtypes of head and neck cancer (PBC), the oral squamous cell carcinoma, is the head and neck cancer more common and is strongly associated with use of tobacco and alcohol. The multifunctional protein SET is an oncoprotein involved in the regulation of apoptosis, transcription, besides being a subunit complex that inhibits histone acetylation by binding to and masking his...
- Study molecular and functional of oncoprotein SET, AP.JP
Abstract
The boarding of this project is that used during the post doc in the exterior in the National Institute of Health (NIH, U.S.A.) (FAPESP process: 05/03380-2) and it constitutes a new line of research to be implanted and to be established in the Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP. The central objective is the protein study selected as markers tumoral using functiona...
- Heterogeneous ribonucleoprotein K role in DNA repair in oral epidermoid cells, BP.MS
Abstract
Heterogeneous ribonucleoprotein K (hnRNPK) has been described as increased in manycancers, including in oral cancer, and associated with their worse prognosis. This protein binds toRNA and DNA and participates in different regulatory protein-protein interactions, being found in thenucleus, cytosol and mitochondria. HnRNPK protein is the target of a series of post-translationalmodificati...
- Study of set and sphingolipids in head and neck cancer: signaling, targets and antitumor therapy, BP.PD
Abstract
Despite the breakthrough in treating some cancers, the search for new therapeutic targets and antitumor therapy to prevent metastasis, relapse and resistance to therapy is needed. The present thematic proposal aims to define the role of the SET protein in the signaling pathway of sphingolipids, as well as their role in head and neck squamous cell carcinoma (HNSCC). Numerous experimental...
- Study of sphingosine kinase 2 and set proteins in sphingolipids signaling in Head and Neck Cancer, BP.DD
Abstract
Despite the breakthrough in the treatment of some types of Cancer, the search for new therapeutic targets and antitumor therapy strategies to prevent metastasis, relapse and resistance to therapy is mandatory. The present proposal aims to define the role of sphingosine kinase 2 and SET in signaling by sphingolipids in oral Cancer. We will carry out studies on human cell derived from tum...
(Only some records are available in English at this moment)
- Evaluation of platelet activating factor receptor function in oral squamous carcinoma cells in vivo and in vitro, BP.DR
Abstract
The oral squamous carcinoma cell (OSCC) is the most common neoplasia of the oral cavity. OSCC has a high rate of local invasiveness and to regional lymph nodes which contributes to poor prognosis. The understanding of their etiopathogenesis can contribute to a better targeting of pharmacological strategies and, consequently, improving the prognosis of this disease. The literature has em...
- Ruthenium nitrosil complex as producer of nitric oxide and singlet oxygen: FOTOBIOLOGICAL studies, BICHEMICAL and their potential therapeutical aplication, BP.PD
Abstract
Elements supporting this project: (i) nitric oxide (NO) is a biological messenger of physiological and anticancer processes, (ii) its functions depend on its concentration and site of action, (iii) the use of NO donos compounds in clinical treatments such as photodynamic therapy (PDT) reach systems capable of releasing NO in a controlled way on biological systems, (iv) ruthenium- nitros...
- The role of set protein in miR-9 methylation profile and DNA repair in human oral squamous cell carcinoma, BP.MS
Abstract
Head and neck squamous cell carcinomas (HNSCC) are tumors of oral cavity, pharynx and larynx and are the sixth most common cancer worldwide. The onset and progression of oral squamous cell carcinoma (OSCC) is a process characterized by the acquisition of genetic and epigenetic alterations, and these are not fully understood. The neoplastic cells show global DNA hypomethylation and promo...
(Only some records are available in English at this moment)
- Targeting sphingosine-1-phosphate axis in obesity-promoted hepatocellular carcinoma, BE.PQ
Abstract
This proposal will provide evidence that the SphK1/S1P/S1PR1 axis is one of the critical factors that bridge obesity, inflammation, and hepatocellular carcinoma (HCC)[1-5]. Surgical procedures such as liver resection and liver transplantation are the first-line treatments for HCC patients. However, the high incidence of tumor recurrence and metastasis after liver surgery remains a major...
- Contribution of PTEN phosphatase in oral cancer formation, BE.EP.DD
Abstract
Cancer is the second cause of death in Brazil and the oral cancer is among the most predominant cancers worldwide. During tumorigenesis several changes occur in the genome, transcriptome, proteome and interatoma leading to malignant cells development. Some of the more important modifications occur in the PI3K-AKT pathway, such as the loss of PTEN phosphatase function, which increase Ptd...
- SET protein in head and neck squamous cell carcinoma , BE.PQ
Abstract
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancy worldwide, representing a major international health problem. Patients in early stages frequently exhibit few symptoms, resulting in diagnosis delay and decrease in survival. Unfortunately, despite intense research and improvements in early detection and therapeutic strategies, the prediction of tumor beh...
| 1 / 1 | Ongoing research grants |
| 3 / 2 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 13 / 10 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 24 / 20 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 130 |
| Cit./Article | 10.8 |
| Data from Web of Science | |
ALMEIDA, LUCIANA O.; GOTO, RENATA N.; PESTANA, CEZAR R.; UYEMURA, SERGIO A.; GUTKIND, SILVIO; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates. FEBS Journal, v. 279, n. 24, p. 4615-4628, DEC 2012. Web of Science Citations: 12. (10/20384-0, 09/10783-7, 09/52228-0, 10/20536-4)
DOS SANTOS, MARCELO; DA CUNHA MERCANTE, ANA MARIA; NUNES, FABIO DAUMAS; LEOPOLDINO, ANDREIA MACHADO; DE CARVALHO, MARCOS BRASILINO; GAZITO, DIANA; MENDOZA LOPEZ, ROSSANA VERONICA; OLGA CHIAPPINI, PAULA BLANDINA; DE CARVALHO NETO, PAULO BENTES; FUKUYAMA, ERICA ERINA; et al. Prognostic significance of NDRG1 expression in oral and oropharyngeal squamous cell carcinoma. MOLECULAR BIOLOGY REPORTS, v. 39, n. 12, p. 10157-10165, DEC 2012. Web of Science Citations: 13. (04/12054-9)
LEOPOLDINO, ANDREIA M.; SQUARIZE, CRISTIANE H.; GARCIA, CRISTIANA B.; ALMEIDA, LUCIANA O.; PESTANA, CEZAR R.; SOBRAL, LAYS M.; UYEMURA, SERGIO A.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS. SET protein accumulates in HNSCC and contributes to cell survival: Antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncology, v. 48, n. 11, p. 1106-1113, NOV 2012. Web of Science Citations: 24. (05/03380-2, 06/06334-4, 10/20384-0, 09/52228-0)
ALMEIDA, LUCIANA O.; GOTO, RENATA N.; NETO, MARINALDO P. C.; SOUSA, LUCAS O.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario. Biochemical and Biophysical Research Communications, v. 458, n. 2, p. 300-306, MAR 6 2015. Web of Science Citations: 5. (10/20384-0, 09/52228-0, 13/01355-7, 13/10898-4, 09/10783-7)
SOBRAL, LAYS M.; COLETTA, RICARDO D.; ALBERICI, LUCIANE C.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET/I2PP2A overexpression induces phenotypic, molecular, and metabolic alterations in an oral keratinocyte cell line. FEBS Journal, v. 284, n. 17, p. 2774-2785, SEP 2017. Web of Science Citations: 3. (13/10898-4, 10/18544-9, 13/08135-2)
ALMEIDA, LUCIANA O.; GARCIA, CRISTIANA B.; MATOS-SILVA, FLAVIA A.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. Accumulated SET protein up-regulates and interacts with hnRNPK, increasing its binding to nucleic acids, the Bcl-xS repression, and cellular proliferation. Biochemical and Biophysical Research Communications, v. 445, n. 1, p. 196-202, FEB 28 2014. Web of Science Citations: 11. (10/20384-0, 07/02223-6, 09/52228-0, 13/10898-4, 09/10783-7)
SOBRAL, LAYS M.; SOUSA, LUCAS O.; COLETTA, RICARDO D.; CABRAL, HAMILTON; GREENE, LEWIS J.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Molecular Cancer, v. 13, FEB 20 2014. Web of Science Citations: 29. (10/18544-9, 10/20384-0, 09/52228-0, 13/10898-4, 13/08135-2)
ALMEIDA, LUCIANA O.; NETO, MARINALDO P. C.; SOUSA, LUCAS O.; TANNOUS, MARYNA A.; CURTI, CARLOS; LEOPOLDINO, ANDREIA M.. SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. ONCOTARGET, v. 8, n. 16, p. 26802-26818, APR 18 2017. Web of Science Citations: 5. (13/10898-4, 09/10783-7, 10/20384-0, 09/52228-0, 13/08135-2, 10/20536-4)
GOTO, RENATA NISHIDA; SOBRAL, LAYS MARTIN; SOUSA, LUCAS OLIVEIRA; GARCIA, CRISTIANA BERNADELLI; LOPES, NORBERTO PEPORINE; MARIN-PRIDA, JAVIER; OCHOA-RODRIGUEZ, ESTAEL; VERDECIA-REYES, YAMILA; LAZARO PARDO-ANDREU, GILBERTO; CURTI, CARLOS; et al. Anti-cancer activity of a new dihydropyridine derivative, VdiE-2N, in head and neck squamous cell carcinoma. European Journal of Pharmacology, v. 819, p. 198-206, JAN 15 2018. Web of Science Citations: 8. (13/01355-7, 13/10898-4)
MARQUI, ALESSANDRA BERNADETE TROVÓ DE; VIDOTTO, ALESSANDRA; POLACHINI, GIOVANA MUSSI; BELLATO, CLÁUDIA DE MATTOS; CABRAL, HAMILTON; LEOPOLDINO, ANDRÉIA MACHADO; GÓIS FILHO, JOSÉ FRANCISCO DE; FUKUYAMA, ÉRICA ERINA; SETTANNI, FLÁVIO AURÉLIO PARENTE; ET AL.. Solubilization of proteins from human lymph node tissue and two-dimensional gel storage. Journal of Biochemistry and Molecular Biology, v. 39, n. 2, p. 216-222, Mar. 2006.
LEOPOLDINO, ANDREIA MACHADO; CANDURI, FERNANDA; CABRAL, HAMILTON; JUNQUEIRA, MAGNO; MARQUI, ALESSANDRA BERNADETE TROVÓ DE; APPONI, LUCIANO H.; FONSECA, ISABEL OSÓRIO DA; DOMONT, GILBERTO BARBOSA; SANTOS, DIÓGENES S.; VALENTINI, SANDRO; et al. Expression, purification, and circular dichroism analysis of human CDK9. Protein Expression and Purification, v. 47, n. 2, p. 614-620, June 2006. (01/07532-0)
LEOPOLDINO, ANDREIA M.; SQUARIZE, CRISTIANE H.; GARCIA, CRISTIANA B.; ALMEIDA, LUCIANA O.; PESTANA, CEZAR R.; POLIZELLO, ANA C. M.; UYEMURA, SERGIO A.; TAJARA, ELOIZA H.; GUTKIND, J. SILVIO; CURTI, CARLOS. Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling. Molecular and Cellular Biochemistry, v. 363, n. 1-2, p. 65-74, APR 2012. Web of Science Citations: 19. (05/03380-2, 06/06334-4, 09/52228-0)
OUCHIDA, AMANDA TOMIE; UYEMURA, VALERIA TUDELLA; QUEIROZ, ANDRE LIMA; BRAUER, VERONICA SOARES; CAVALCANTI-NETO, MARINALDO PACIFICO; SOUSA, LUCAS OLIVEIRA; UYEMURA, SERGIO AKIRA; CURTI, CARLOS; LEOPOLDINO, ANDREIA MACHADO. SET protein accumulation prevents cell death in head and neck squamous cell carcinoma through regulation of redox state and autophagy. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v. 1866, n. 4, p. 623-637, APR 2019. Web of Science Citations: 1. (16/19103-2, 09/52228-0, 13/10898-4)
VIDOTTO, ALESSANDRA; POLACHINI, GIOVANA M.; DE PAULA-SILVA, MARINA; OLIANI, SONIA M.; HENRIQUE, TIAGO; LOPEZ, ROSSANA V. M.; CURY, PATRICIA M.; NUNES, FABIO D.; GOIS-FILHO, JOSE F.; DE CARVALHO, MARCOS B.; et al. Differentially expressed proteins in positive versus negative HNSCC lymph nodes. BMC MEDICAL GENOMICS, v. 11, AUG 29 2018. Web of Science Citations: 0. (04/12054-9)
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Flávia Amoroso Matos e. Estudos das proteínas hnRNP K, SET e MARK3 como potenciais marcadores de prognóstico em câncer epidermóide de cabeça e pescoço (HNSCC). 2009. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (07/02223-6)
TANNOUS, Maryna Aguilar. O papel da proteína SET no perfil de metilação do miR-9 e no reparo de DNA em células humanas de carcinoma espinocelular oral. 2014. Dissertação (Mestrado) - Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (12/12928-5)
GOTO, Renata Nishida. Estudo in vitro e in vivo de novos compostos: com alvo-específico (hnRNP K e SET) ou com ação na mitocôndria para uso como antitumoral em carcinoma oral ou como citoprotetor em célula não-tumoral. 2017. Tese (Doutorado) – Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (13/01355-7)
MATSUMOTO, Camila Sayuri. Potenciais mecanismos de regulação da fosfatase PTEN pelas proteínas SET e PP2A e seu envolvimento na predisposição ao carcinoma bucal. 2016. Tese (Doutorado) – Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (10/17985-1)
PADOVANI, Karina Stringhetta. Análise da proteína hnRNP K nas linhagens celulares NB4 e NB4-R2 de leucemia promielocítica aguda com ênfase na patogênese e na diferenciação celular pelo ácido all-trans retinoico. 2017. Tese (Doutorado) – Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de São Paulo (USP). Ribeirão Preto. (13/00374-8)