Leoberto Costa Tavares

• Abstract

  Considered as a neglected disease, Chagas' disease affects around 10 million people in Latin America and an increasing number of new cases in non-endemic areas. The search for therapeutic alternatives for this disease has an important role, since the current options are limited, and and only benznidazole is available in Brazil, which is the only active drug for the chronic phase of the di…

  Nitro-compounds with Trypanosoma cruzi activity: design, synthesis, evaluation of cytotoxicity and bioactivity in vitro and studies of structure-activity relationships in silico, AP.R

• Abstract

  The resistance of microorganisms to antimicrobial agents, which the best example is methicilin-resistant Staphylococcus aureus, MRSA strain, is considered a worldwide health public problem, due to the high levels of morbidity, mortality and easily spread wide.The vancomycin structure, first choice in the treatment of MRSA infections, is composed by seven amino acids, two sugar molecules a…

  Stability of vancomycin in large volume parenteral solution and/or in association with drugs: use of green fluorescent protein (GFP) as biosensor of stability, AP.R
• Design, synthesis, evaluation of antichagasical activity and structure-activity relationship studies of nitro-heterocyclic compounds with azomethynic and oxadiazolinic structures, AP.R

• Abstract

  The design of new drugs effective in the treatment of Chagas disease, caused by Trypanosoma cruzi, have shown great need because there are only two drugs currently in use, the benzinidazol and nifurtimox, the latter being banned in Brazil. Nitro Compounds with anti-cruzi activity have shown promising results thus this work involves a series of substituted 5-nitro-furfurylidene and their s…

  Design, synthesis and evaluation anti-T.cruzi activity of 5-nitrofurfurilidenes derivatives based in SAR/QSAR strategies, BP.IC

• Abstract

  Nosocomial infections are caused by fungis or bacteria and are the cause of millions of deaths every year. The primary aim are pacients with low immunity, like immunosuppressed and persons in the age extreme. Today, with the rising of resistant nosocomial infections, mainly because of the excess of antibiotics prescription, the research for new drugs is crucial, and the nitrocompounds, es…

  Design, synthesis and evaluation of antimicrobial activity of novel furfuryliden derivatives against nosocomial infections., BP.MS

• Abstract

  The search for alternative therapies for the treatment of Chagas disease is very important, since currently there are only two drugs available, benznidazole and nifurtimox. Both of them have considerable adverse effects, and only benznidazole is used in Brazil. In addition, these drugs are ineffective in the chronic phase. The need to search for new alternatives to combat Chagas disease i…

  Design, synthesis, identification and anti-Trypanosoma cruzi activity evaluation of furfurylidene azomethine and oxadiazole derivatives., BP.MS

(Only some records are available in English at this moment)