Cleslei Fernando Zanelli

• Abstract

  Many of the discoveries from the rapidly expanding genomic sciences are not effectively utilized in medicine, agriculture and industry. This is partly because of the disconnection between scientists in different disciplines, and because much of the translational research done in both industry and academia is patent-protected and not published in a timely manner. This INCT proposal address…

  INCT 2014: Open-acess Medicinal Chemistry Centre (OpenMedChem), AP.TEM

• Abstract

  The translation factor 5A (eIF5A) is highly conserved in Archaea and eukaryotes and is essential for cell viability. This is the only protein known to contain the amino acid residue hypusine, essential for eIF5A function, generated by a post-translational modification. The functional homolog of eIF5A in bacteria is the EF- P factor. The crystal structure of EF-P bound to 70S ribosome show…

  Study of the impact of the role of eIF5A in the cell proteomic profile using Saccharomyces cerevisiae as a model, AP.R
• 4th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives, AR.EXT

(Only some records are available in English at this moment)

• Abstract

  The eukaryotic translation factor 5A (eIF5A) is a highly conserved translation elongation factor in eukaryotes and it is essential for the viability of all organisms tested so far. eIF5A undergoes a specific post-translational modification, called hypusination, which is required for its function in the cell. Hypusination occurs in two steps, involving two different enzymes (deoxy-hypusine…

  Structural determination and search for inhibitors of the enzyme deoxy-hypusine synthase of eukaryotic organisms that cause neglected tropical diseases, BP.DR

• Abstract

  The ribosome is responsible for catalyzing protein synthesis and is supported by several translation factors at all stages of the process (initiation, elongation, termination, and recycling). Although important differences are observed in the initiation, termination and recycling phases between prokaryotes and eukaryotes, the translation elongation has conserved factors in the three major…

  Study of the impact of eIF5A function on cellular processes involving mitochondria, BP.IC

• Abstract

  The translation factor 5A (eIF5A) is highly conserved in Archaea and eukaryotes and is essential for cell viability. This is the only protein known to contain the amino acid residue hypusine, essential for eIF5A function, generated by a post-translational modification. The functional homolog of eIF5A in bacteria is the EF- P factor, which also undergoes a modification of lysyl or arginyl-…

  Study of the eIF5A impact on cellular proteomic profile using Saccharomyces cerevisiae as model, BP.DR

(Only some records are available in English at this moment)

• Abstract

  The eukaryotic initiation translation factor 5A (eIF5A) is highly conserved in eukaryotes and undergoes a specific post-translational modification, called hypusination. Hypusination is required for eIF5A function in the cell and is only present in eIF5A. Deoxyhypusine synthase (DHPS) catalyzes the first step of this modification in eIF5A. Both DHPS and eIF5A are essential for cell viabili…

  Search for inhibitors of the enzyme deoxyhypusine synthase of eukaryotic organisms that cause neglected tropical diseases by high-throughput in vitro drug screening, BE.EP.DR

• Abstract

  The translation factor 5A (eIF5A) is highly conserved in archaea and eukaryotes and is essential for cell viability in all organisms tested so far. eIF5A undergoes a unique post-translational modification which essential for its function, wherein a lysine residue is converted into a hypusine. eIF5A and its functional counterpart in bacteria, EF-P, associate between the peptidyl (P) and th…

  Functional correlation of eIF5A with the Quality Control (RQC) complex, BE.PQ

• Abstract

  The translation factor 5A (eIF5A) is conserved and essential for cell viability. This is the only protein known to contain the amino acid residue hypusine, essential for eIF5A function, generated by a post-translational modification. Although it was initially suggested a function for eIF5A in the translation initiation, eIF5A has been demonstrated to have a role in translation elongation.…

  Impact of the role of eIF5A in the translation of proteins imported into the Endoplasmic Reticulum and mitochondria, BE.EP.DR

(Only some records are available in English at this moment)