Lea Rodrigues Simioni

• Abstract

  The Neuromuscular Junction Laboratory (NJL) of the Department of Pharmacology of the State University of Campinas (UNICAMP) has been investigating the neuromuscular actions of animal venoms (principally snake venoms and their neurotoxins and myotoxins) for over 25 years, with over 70 publications in peer-reviewed journals during this period. The NJL (~50 m2) has the basic infrastructure r…

  Proposal for a short-term visit by Dr. Edward G. Rowan to Brazil, AV.EXT
• Neuromulscular activity of toad (chaunus schneideri) venom., AR.EXT
• Purification and pharmacological characterization of btii-2 a novel presynaptic pla2 isolated from bothrops alternatus venom., AR.EXT

(Only some records are available in English at this moment)

• Abstract

  Bothropic snake venoms are a complex mixture of substances with different properties (mainly proteolytic, hemorrhagic and coagulant) that exert local action producing intense pain, edema, hemorrhage and necrosis, associated with systemic damage as coagulopathy, systemic bleeding and renal failure. Bothrops fonsecai, inhabits a limited area of Araucaria forest (Araucaria augustifolia) in A…

  Study of biological activities induced by Bothrops fonsecai snake venom and the uso of commercial bothropic antivenom as a pharmacological tool., BP.MS

• Abstract

  Bothrops sp. snake venoms cause an extensive local damage such as pain, edema, hemorrhage and necrosis, associated with systemic damage as coagulopathies systemic hemorrhage and renal failure. In Brazil, these cases are treated with serotherapy by commercial bothropic antivenom that consists in antivenom obtained by horse hyperimmunization with Bothrops snake venoms. Although not present …

  Analysis of antibody-antigen interactions (venom: antivenom) using size-exclusion high-performance liquid chromatography, BE.EP.MS