CV Lattes
ORCID
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Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade Presbiteriana Mackenzie (1998), master's at Genetics from Universidade Estadual Paulista Júlio de Mesquita Filho (2001) and doctorate at Genetics from Universidade de São Paulo (2006). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: bovino, marcadores moleculares, receptores de hormônios, embrião and clonagem. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Fertilization markers |
| Marcadores de la fertilización |
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| News published in Agência FAPESP Newsletter about the researcher |
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| TITULO |
| Articles published in other media outlets ( ): |
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| VEICULO: TITULO (DATA) |
During early development, the pre-implantation embryo undergoes an intense process of metabolic, molecular, and epigenetic reprogramming, which must be adequately orchestrated to support the events that will culminate in the generation of a new individual. Understanding these mechanisms is of fundamental importance for the development of increasingly efficient assisted reproduction techni…
Reproductive processes involve complex and finely orchestrated events that allow for the maintenance and propagation of species. Currently, scientific and technological advances allow research to be conducted globally, which may represent a revolution in the understanding of the mechanisms involved in these processes. In addition to elucidating the key events of these processes, there may…
During the early stages of development, the pre-implantation embryo undergoes an intense process of metabolic, molecular, and epigenetic reprogramming, which must be properly orchestrated for it to support the events that will lead to the generation of a new individual. Understanding these mechanisms is of fundamental importance for the development of efficient assisted reproduction techn…
(Only some records are available in English at this moment)
In vitro culture systems are determinant in embryo development and can impact not only blastocyst rates and viability but also the offspring. One of the main factors influenced by changes in these systems is the embryonic metabolism. At the earliest stages of embryo development, the energetic requirements are mainly maintained by oxidative phosphorylation through high consumption of pyruv…
The effects of the in vitro system on the development of the pre-implantation embryo are determinant for its viability and post-transfer success. Modifications in this system have been suggested, especially in relation to the increase of energy metabolism by the modulation of substrates such as glucose, pyruvate and several amino acids. However, the impact of these supplements may be beyo…
In vitro production of bovine embryos is still considered a low-efficiency biotechnology, once the technique has, on average, lower pregnancy rates when compared to in vivo. Although the in vitro culture system tries to mimic what occurs in vivo, embryos end up being exposed to various stress factors that they would usually do not suffer inside the reproductive tract. In addition to intri…
(Only some records are available in English at this moment)
The development of technologies for improving the in vitro embryo production (IVP) system has been widely investigated due to the impacts this environment has on embryonic development. Recently, the epigenetic profile of the embryo has become a focus of research, following studies that show that IVP embryos exhibit different levels of DNA methylation compared to embryos produced in vivo-a…
Epigenetic mechanisms, such as DNA methylation and hydroxymethylation, play crucial roles in organism development, regulating the expression of genes essential for lineage determination and cellular identity. During bovine embryonic development, there is a shift in the utilization of energy substrates, which is directly linked to DNA methylation and other epigenetic mechanisms. Despite im…
(Only some records are available in English at this moment)
Modifications of the in vitro embryo production system may be determinant for the adequate development of the pre-implantation embryo. Modifications related to energy metabolism, such as increased or decreased availability of substrates, may have consequences not only in survival but also in molecular control of the embryo. At the beginning of development, pyruvate and to some extent lact…
The oviduct is the anatomical region where life begins in most mammal species, as it is the meeting point between sperm and oocytes for fertilization, in addition to providing the appropriate environment for early embryonic development. The reproductive events that occur in the oviduct depend on synchronized signaling processes, which involve communication between the different types of c…
In vitro maturation (MIV) is one of the primordial steps for the success of in vitro production (PIV) of bovine Embrys, since there is the triggering of severe processes that collaborate for the development and the quality of the future embryo. Epigenetic reprogramming is one of the processes carried out in MIV, in which the bovine oocyte goes through an intense regulation of Epigenetic m…
(Only some records are available in English at this moment)
The existence of early embryomaternal communication already in the oviducts has been for too long underestimated. It is observed that the oviducts are cyclically prepared to receive a pregnancy in each estrous cycle, but when the embryo is indeed present, it is now known that a two-way communication is established between the oviductal cells and the embryo. Even though this communication …
The epigenetic reprogramming that occurs during the earliest stages of the embryonic development has been described as crucial for the initial events of cell specification and differentiation. Recently, the metabolic status of the embryo has gained attention as one of the main factors coordinating epigenetic events. For this present proposal, we start from previous results with the hypoth…
During the first cleavages of bovine embryos, the DNA demethylation (active and passive) occurs and will be responsible for the production of totipotent cells, until around 8-16 cells. Then the DNA of these embryos must be methylated again until, at the blastocyst stage, when its blastomeres are classified as pluripotent and differentiated as belonging to the internal cell mass or trophec…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 11 / 8 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 14 / 10 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 39 / 32 | All research grants and scholarships |
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