CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Licenciatura Em Ciências Biológicas from Instituto de Biociências Letras E Ciências Exatas (1996), master's at Morphology from Universidade Federal de São Paulo (1999) and ph.d. at Ciências (Morfologia) from Universidade Federal de São Paulo (2005). Has experience in Morphology, focusing on Embryology, acting on the following subjects: microtomia, métodos de coloração, fixação, inclusão em parafina and preparado histológico permanente. (Source: Lattes Curriculum)
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Diabetes mellitus (DM) is a global public health issue that leads to systemic dysregulation, causing neurological, cardiovascular, renal, and ocular complications. Hyperglycemia in DM induces mitochondrial dysfunction and increases superoxide production, activating pathological pathways linked to these complications. As DM cases rise, we must deepen our understanding of its mechanisms to …
Annexin A1 (AnxA1) is a Ca²¿-regulated phospholipid-binding protein secreted by epithelial, cancer, and immune cells to mediate survival, proliferation, apoptosis, differentiation, and migration. AnxA1 is found in the cytoplasm, mostly associated with vesicular structures, and is distributed throughout the cell and at the inner leaflet of the plasma membrane. It is translocated into the n…
Exposure to stress during development alters brain maturation, leading to different behavioural phenotypes. Although adversities in childhood and adolescence increase the risk for stress-related psychiatric disorders (SRPD) such as anxiety, panic, depression and posttraumatic stress disorder (PTSD), there is significant individual variability in the outcomes, indicating the existence of s…
One of the focuses of our research group has been to investigate the pathophysiological relevance of the anti-inflammatory protein annexin A1 (AnxA1) and its mimetic peptides in different models of inflammation through a combination of histopathological, pharmacological, and ultrastructural analyses. On the other hand, we also seek to identify targets that mediate endogenous anti-inflamma…
Annexin A1 (AnxA1) is a 37 kDa protein capable of regulating various cellular and molecular stages of the inflammatory response and is involved in endogenous mechanisms that are activated to obtain an adequate resolution. In addition, some synthetic peptides derived from the N-terminal domain of AnxA1 mimic the pharmacological property of the total protein, especially its anti-inflammator…
In the last years, the research by our group has been focused the role of proteins with anti and proinflammatory activities, specially the galectins-1, -3 and annexin A1 (ANXA1), using different experimental models of inflammation. Thus, these investigations have been expanded with a dual approach: 1) on one hand, the patho-physiological relevance of these mediators in different models of…
(Only some records are available in English at this moment)
Type 1 diabetes mellitus (DM1) is an autoimmune disease characterized by the destruction of pancreatic beta cells and consequent absolute insulin deficiency, leading to various metabolic and organic complications, including significant liver changes. Metabolic dysfunction-associated steatotic liver disease (MASLD) and glycogenic hepatopathy are conditions that are increasingly recognized …
Diabetes mellitus (DM) is considered a chronic disease that affects thousands of people and is identified as a risk factor for coronary heart disease. Moreover, it leads to hormonal changes during menopause, where there is a decline in estradiol levels, which increases cardiovascular risk. In this context, Annexin A1 (AnxA1) stands out as an anti-inflammatory protein that, in addition to …
Psoriasis (Pso) is a chronic skin desease that has a genetic predisposition and depends also on environmental factors, with a prevalence of up to 1,3% in the Brazilian population. Its characteristics is the constant peeling of especific areas such as hands, feet, elbows and the back of the neck. Its pathogenesis occurthrough different triggers that will stimulate keratinocytes to secret p…
(Only some records are available in English at this moment)
Type 1 diabetes (T1D) is a global public health problem, which leads to systemic dysregulations that affect multiple tissues, including serious liver complications. Among liver changes, abnormal deposition of lipid droplets, formation of cytoplasmic and/or nuclear vacuoles, mitochondrial damage, increased production of ROS and death by apoptosis stand out. Patients with DM2 have high plas…
In Brazil, there are currently more than 15.5 million people (20-79 years old) living with diabetes mellitus (DM), ranking sixth among the top 10 countries with the disease. In the kidneys, high circulating glucose levels lead to excessive production of reactive oxygen species (ROS) by mitochondria, generating activation of oxidativestress. Furthermore, the production of ROS is associated…
The complex interaction between intestinal microbiota and inflammation is related to intestinal permeability, indicating that endothelial dysfunction is a primary feature of type 1 diabetes (T1D). The annexin A1 (AnxA1) protein, found in inflamed tissues of the intestinal mucosa, acts in the inflammatory response and in the regulation of intercellular junction proteins, such as ZO-1 and c…
(Only some records are available in English at this moment)
Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disease characterized by vascular remodeling and high mortality. Its pathophysiology involves metabolic and mitochondrial imbalances in the cells of the lung, right ventricle, and liver. Inflammation triggered by the NLRP3 inflammasome can induce mitochondrial dysfunction. This study aims to evaluate the therapeutic p…
Introduction: The human genome encodes 12 annexins, including annexin A1 (AnxA1), knownfor its role in inflammation and immune regulation. Previous research indicates theneuroprotective properties of AnxA1 and its N-terminal peptide, Ac2-26, in promoting a proresolving response in neurological diseases. AnxA1 interacts with the NLRP3 inflammasome(NLRP3), forming a pro-resolution regulator…
Diseases that affect the retina have common triggers, such as oxidative stress, inflammation, and neuronal death in the retina. In the search for new potential therapeutic targets, retinal organoids emerge as a robust and technological platform that can aid in the discovery of new therapies. Annexin A1 (AnxA1) belongs to a family of proteins that bind to membrane phospholipids in a calciu…
| 3 / 3 | Ongoing grants |
| 10 / 7 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 24 / 23 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 45 / 41 | All research grants and scholarships |
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