CV Lattes
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ORCID
Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
undergraduate at Fisioterapia from Universidade do Grande Abc (2001), master's at Physiology from Universidade de São Paulo (2003) and ph.d. at Physiology from Universidade de São Paulo (2007). Has experience in Byophysics, acting on the following subjects: cholesterol, proton, permeability, conductance and black lipid membrane. (Source: Lattes Curriculum)
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This project aims to design new cationic peptide sequences with selective action against cancer cells and bacteria. With a multidisciplinary approach, the present project proposal will allow, besides the determination of structural aspects of the studied peptides, to simultaneously obtain temporal and spatial resolution of the mechanisms involved in the action of cationic peptides in cell…
This project has as main objective to obtain dynamic images of changes in intracellular pH (pHi) in microglia cells. Unlike other pHi measurement methods, the use of fluorescence microscopy will provide us with simultaneously spatial and temporal resolution of the events involved in maintaining the microglial pHi. Three majors will be studied: 1) the relationship between the composition o…
The increasing resistance of bacteria to conventional antibiotics has stimulated efforts to obtain antimicrobial compounds with different mechanisms of action. Among these, it has been notable peptides like amphipathic ±-helix peptides that operate mostly permeabilizing the cell membrane of the pathogen causing him to death. It is believed that electrical factors exert dominant role in pe…
(Only some records are available in English at this moment)
The endocannabinoid system plays a central role in physiological processes by modulating its action. This system comprises highly hydrophobic endocannabinoid ligands (eCBs), cannabinoid receptors (CB1 and CB2) and proteins involved in metabolic issues. Opposite to the canonical vision of the system, which associates the endocannabinoid action with classical receptors, experimental evidenc…
The bullfrog (Lithobates catesbeianus) is originally from North American, but was introduced in Brazil in 1935, and nowadays it is commonly created in commercial ranches. Studies on morphological characterization of the stages of development of the female reproductive tract showed great similarity with the development of the Xenopus laevis frog. In both cases, it was possible to classify …
The voltage gated proton channel (HV1) plays an important role during microbial killing by phagocytes, such as neutrophils and microglia. Besides its physiological functions, recent studies have shown that HV1 channel participates in pathological states, not only increasing tissue damage in ischemic stroke, but also promoting the proliferation and survival of tumoral cells. Even though th…
Even though cancer is the leading cause of death worldwide, there still not efficient treatment alternatives to substitute chemotherapy, the main course of treatment used today. With few alternatives to this kind of treatment, antimicrobial peptides (AMPs) stands out as promising antitumoral drugs. These peptides are products of the immune system of plants, insects and animals, and some t…
(Only some records are available in English at this moment)
| 4 / 4 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 7 / 6 | Completed scholarships in Brazil |
| 12 / 11 | All research grants and scholarships |
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