CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciências Biológicas from Universidade de São Paulo (2002) and ph.d. at Microbiology from Universidade de São Paulo (2007). Has experience in Genetics, focusing on Molecular Genetics and of Microorganisms, acting on the following subjects: plasmid vector, xylella fastidiosa and gene disruption. (Source: Lattes Curriculum)
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Bacteria have sophisticated mechanisms to survive in hostile environments. Bacterial pathogens must deal with harsh stress conditions inside the host, such as oxidative stress and limitation of the essential metals iron, zinc, and manganese. This project aims to unravel how the environmental opportunistic pathogen Chromobacterium violaceum coordinates adaptive responses of metal homeostas…
Gram-negative bacteria secrete proteins into the extracellular milieu or into host cells using protein devices called Type I to Type VI secretion systems or by releasing outer membrane vesicles (OMV). In this project, we propose to investigate the role of several of these secretion systems in the physiology and virulence of the opportunistic bacterium Chromobacterium violaceum. Studies ha…
Iron is essential for most organisms but has low solubility and high toxicity in aerobic environments, in which life predominates. Bacteria have sophisticated mechanisms to maintain control of iron levels, whether in the environment or inside vertebrate hosts. In this work, we will investigate the role and regulation of candidate genes for systems of uptake, utilization, and regulation of…
Transcription factors have a central role in the hierarchy of control of gene expression by binding to specific DNA sequences, thereby modulating transcription initiation. The integration of these regulatory proteins in signal transduction pathways allows bacteria to monitor various physico-chemical parameters and develop appropriate adaptive cellular responses. Thus, the study of these p…
Superoxide dismutases (SODs) are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen using metals as cofactors. Combating oxidative stress by SODs is an essential mechanism for life, as it prevents damage to macromolecules caused by the superoxide radical. Opportunistic pathogenic bacteria such as Chromobacterium violaceum are also exp…
(Only some records are available in English at this moment)
The transition metal zinc is an essential micronutrient for all organisms due to its structural and catalytic function in several proteins. However, excess zinc causes intoxication by the mismetallation of proteins. The Zinc Uptake Regulator (Zur) controls at transcriptional level the zinc homeostasis in several bacteria. The discovery of the repertoire of Zur-regulated genes provides nov…
(Only some records are available in English at this moment)
Zinc is a transition metal required as a trace micronutrient for all living organisms. The zinc dual nature - vital for life, toxic in excess - has intriguing implications in host-pathogen interaction. Zinc toxicity can be used by the host as a defense mechanism against pathogens. For instance, immune cells and amoeba can accumulate zinc in the phagosome as part of an antimicrobial respon…
The bacterial cell wall is composed of peptidoglycan, a macromolecule that acts to confer rigidity, resistance, and osmotic stability. The cycle of peptidoglycan synthesis, degradation, and recycling is critical for bacterial cell homeostasis. Used on the front lines against different infections, ²-lactam antibiotics prevent peptidoglycan synthesis. Different forms of bacterial resistance…
The type VI secretion system (T6SS) is a complex nanomachine used by Gram-negative bacteria to deliver effector proteins into target cells. Although some T6SS effectors have anti-host and anti-fungi activity, the T6SS is mainly involved in interbacterial competition through the secretion of antibacterial effectors. Chromobacterium violaceum is a free-living, saprophytic, Gram-negative ²-p…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 5 / 3 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 31 / 26 | Completed scholarships in Brazil |
| 4 / 4 | Completed scholarships abroad |
| 47 / 40 | All research grants and scholarships |
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