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Ministério da Ciência, Tecnologia e Inovações (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Ana Carolina Migliorini Figueira in research grants and scholarships supported by FAPESP.
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Obesity and type 2 diabetes are chronic diseases characterized by increased body fat and insulin resistance. The growing number of new cases per year have been considered alarming and, for this reason, the development of new therapies has considerable importance. In this scenario, nuclear receptors play fundamental roles, being important modulation targets. The PPAR³ is one of these targe…
Obesity and type 2 diabetes are chronic diseases characterized by increased body fat and insulin resistance. The growing number of new cases per year have been considered alarming and, for this reason, the development of new therapies has considerable importance. In this scenario, nuclear receptors play fundamental roles, being important modulation targets. The PPAR³ is one of these targe…
Nuclear Receptors (RNs) are proteins that compose a superfamily of transcription factors generally modulated by ligands. The RNs are involved in several functions of the life organisms, regulating gene transcription related to many processes as differentiation, development, metabolism, and reproduction, among others. Additionally, the RNs are directly related to pathologies, being targets…
(Only some records are available in English at this moment)
The Metabolic Syndrome is a cluster of conditions that happens together. These conditions disrupt the body glycose levels homeostasis, which leads to a resistance to respond to insulin. The thiazolidinediones (TZDs) are the main drug for the treatment of Metabolic Syndrome. It targets the ligate-dependent nuclear receptor (RN) PPAR³ where it acts as a strong agonist. The PPAR³ is a key pl…
Nuclear receptors are regulators of various processes of animal metabolism and therefore play an important role in acting as drugs for various metabolic diseases. The peroxisome proliferator-activated receptor gamma (PPAR³) is the master regulator of general lipid metabolism and insulin sensitivity, being the main responsible for the process of adipogenesis. Its activation occurs through …
Obesity and metabolic syndrome are global epidemics that tend to grow. In these conditions the transcription of several genes is altered, including that of adiponectin, a protein responsible for a set of metabolic regulations that result in the sensitization of the organism to insulin, whose expression is decreased in obese individuals, being that the main factor for the development of di…
Flexibility and conformational changes are fundamental aspects for understanding how proteins perform their biological functions. Experimental and computational works have extensively studied dynamic properties and interactions that lead proteins to different configurations, and how these changes are related to function. One protein that is known to have a disperse set of accessible confi…
Nuclear Receptors (NRs) correspond to a superfamily of ligand modulated transcription factors that act in the regulation of specific genes. The orphan receptor, Coup-TFII (Chiken ovalbumin upstream promoter transcription factor) has been suggested as one of the key factors involved in cardiac development, controlling slow myosin heavy chain (SMyHC III) gene. The promoter involved in the a…
(Only some records are available in English at this moment)
PPAR gamma is the main regulator of adipogenesis and insulin sensitization, and therefore it is widely studied as a therapeutic target for modulating the metabolic processes that involve obesity. PGC-1 alpha is a coregulator partner of PPARgamma, it acts together to regulate genes involved mainly in beta-oxidation and browning processes. Previous results from our group have shown that the…
Nuclear Receptors (NRs) belong to a superfamily of transcription factors regulated by ligands. They act on the transcription of specific genes and they are involved in several processes such as cell proliferation, homeostasis, metabolism and others. The receptors COUP-TFII (Chicken ovalbumin upstream promoter-transcription factor) and GR (glucocorticoid receptor) have been associated to d…
PPARs and LXRs are lipid-activated transcription factors that belong to the nuclear receptor superfamily. Both types of receptors are activated by ligands from dietary lipids, such as fatty acids and cholesterol metabolites (oxysterols), respectively. They are intrinsically involved in metabolic pathways related to inflammation, diabetes, obesity and cardiovascular diseases, which make th…
The Peroxisome Proliferator-activated Receptor beta/delta (PPAR²) is a transcription factor, member of the nuclear receptor's superfamily. This protein can be found in several human tissues, mainly in those involved in high lipid metabolism and dependent on cell proliferation and differentiation, such as skin, intestine, placenta, adipose tissue, brain and skeletal muscle. PPAR² heterodim…
(Only some records are available in English at this moment)
| 5 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 17 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 29 / 23 | All research grants and scholarships |
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