CV Lattes
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Ministério da Ciência, Tecnologia e Inovação (Brasil). Centro Nacional de Pesquisa em Energia e Materiais (CNPEM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from UFSCar (2003) and PhD in Sciences from the Institute of Physics at USP São Carlos, with a specialization in Biomolecular Applied Physics (2008). She completed part of her postdoctoral research at the University of Houston and The Methodist Research Institute (2009), in addition to a second postdoctoral fellowship at the University of São Paulo, in the Protein Crystallography group of IFSC (2008 and 2010). With a solid background in Biochemistry, Cellular and Molecular Biology, Structural Biology, and Biophysical Techniques, as well as Tissue Engineering, she has dedicated her career to the investigation of various areas. Her skills range from the structural characterization of proteins to the assembly and stabilization of protein-protein and protein-DNA complexes, encompassing spectroscopic studies, structural stability analysis, and protein biophysics, as well as the characterization of biopharmaceuticals. She coordinated the Spectroscopy and Calorimetry Laboratory from 2011 to 2024. She actively participated in projects focused on the development of diagnostic tests and contributed to the COVID task force at CNPEM. Since 2020, she has initiated a research line in Tissue Engineering, focusing on the development and characterization of reconstructed skin models, 3D cultures, and organoids, aiming at the pursuit of alternative methodologies to animal use and toxicological studies through microfluidic systems. She works in the field of regenerative medicine, developing biological dressings for skin and heart injuries. Her primary research focus includes metabolic syndrome, obesity, diabetes, tissue bio-printing, and skin remodeling. She currently coordinates the 3D Cultures and Microfluidics Laboratory at LNBio - CNPEM, as well as leading the Tissue Engineering Platform at LNBio/CNPEM. She represents LNBio as a Central Laboratory associated with RENAMA and is affiliated with the International Microfluidic Systems Society (iMPS). Since 2019, she has been a productivity fellow at CNPq. (Source: Lattes Curriculum)
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Diabetic skin problems are a serious health condition with currently poor effective cure. In this project we will develop 1) regenerative scaffolds (advanced materials) with the ability to promote skin healing of diabetic wounds and 2) a three-layered in vitro human skin modeling hypodermis, dermis and epidermis, for usage as a non-clinical in vitro template to study diabetic skin. Molecu…
Obesity, type 2 diabetes, and fatty liver disease are chronic diseases characterized by increased body fat, inflammation, and insulin resistance. Its increasing numbers of new cases are considered alarming and therefore the development of new therapies is of great importance. In this context, PPAR³ is a modulation target, acting effectively in adipogenesis and insulin sensitization. Sever…
Obesity and type 2 diabetes are chronic diseases characterized by increased body fat and insulin resistance. The growing number of new cases per year have been considered alarming and, for this reason, the development of new therapies has considerable importance. In this scenario, nuclear receptors play fundamental roles, being important modulation targets. The PPAR³ is one of these targe…
(Only some records are available in English at this moment)
Pharmacological and toxicological assays are of utmost importance in determining the effectiveness of new chemical composition products and their adverse effects. Although the use of animals and 2D cell cultures has been essential, they have limitations in predicting human responses. Ethical debates such as the "Principle of the 3Rs" have encouraged the search for alternative methods, suc…
Chronic non-healing skin wounds are among the most socially and economically impactful complications of diabetes. However, there is currently no universally effective therapy, primarily due to the lack of comprehensive understanding of the complex pathophysiology of diabetic wound healing. Therefore, there is a critical need to develop more robust and highly predictive non-clinical human …
Diabetic skin problems are considered serious in the health sector, with currently ineffective cures. In this project we will develop dressing models based on regenerative scaffolds (advanced materials) with the ability to promote skin healing in diabetic wounds. Furthermore, we will develop a skin model containing hypodermis, dermis and epidermis, and we will induce diabetic conditions i…
(Only some records are available in English at this moment)
Nuclear receptors are regulators of various processes of animal metabolism and therefore play an important role in acting as drugs for various metabolic diseases. The peroxisome proliferator-activated receptor gamma (PPAR³) is the master regulator of general lipid metabolism and insulin sensitivity, being the main responsible for the process of adipogenesis. Its activation occurs through …
Obesity and metabolic syndrome are global epidemics that tend to grow. In these conditions the transcription of several genes is altered, including that of adiponectin, a protein responsible for a set of metabolic regulations that result in the sensitization of the organism to insulin, whose expression is decreased in obese individuals, being that the main factor for the development of di…
Flexibility and conformational changes are fundamental aspects for understanding how proteins perform their biological functions. Experimental and computational works have extensively studied dynamic properties and interactions that lead proteins to different configurations, and how these changes are related to function. One protein that is known to have a disperse set of accessible confi…
(Only some records are available in English at this moment)
Metabolic syndrome is a cluster of conditions that happens simultaneously within the body and may lead to clinical conditions such as obesity and type II diabetes. This work focus on the structural investigation of the deacetylase SIRT1 and the nuclear receptor PPAR³, a master regulator of adipogenesis and glucose homeostasis. Recently studies demonstrate that PPAR³ controls adipogenesis …
PPAR gamma is the main regulator of adipogenesis and insulin sensitization, and therefore it is widely studied as a therapeutic target for modulating the metabolic processes that involve obesity. PGC-1 alpha is a coregulator partner of PPARgamma, it acts together to regulate genes involved mainly in beta-oxidation and browning processes. Previous results from our group have shown that the…
Nuclear Receptors (NRs) belong to a superfamily of transcription factors regulated by ligands. They act on the transcription of specific genes and they are involved in several processes such as cell proliferation, homeostasis, metabolism and others. The receptors COUP-TFII (Chicken ovalbumin upstream promoter-transcription factor) and GR (glucocorticoid receptor) have been associated to d…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 7 / 6 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 18 / 13 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 36 / 30 | All research grants and scholarships |
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