André Gustavo Tempone Cardoso
CV Lattes
ResearcherID
ORCID
Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Controle de Doenças (CCD). Instituto Adolfo Lutz (IAL) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Professor of Parasitology at Adolfo Lutz Institute since 2004, coordinator of the the central public health institute of the Secretary of Health of São Paulo State. He has >20 years? experience working with trypanosomatids and an excellent international collaboration track record with UK and USA universities. He has published 86 peer-reviewed primary research articles, 4 reviews and 3 book chapters. Degree in Pharmacy (1997), Master IPEN-University of Sao Paulo (1999) and PhD in Biology of Host-Pathogen Interactions - ICB-University of Sao Paulo (2003), with part of PhD at the London School of Hygiene and Tropical Medicine (2001-2001, - Prof. Simon L. Croft). Post-doctorate in Toxinology at Federal University of Sao Paulo (UNIFESP). Coordinator of the Laboratory Novel Drugs -Neglected Diseases (since 2004) and vice-director of the Centre for Parasitology and Mycology (since 2009). Vice coordinator of the Post-Graduation Program of the Secretary of Health of São Paulo State and coordinator of the Program Laboratory Research in Public Health. Professor at the Post-graduation Program of University of São Paulo-Institute of Tropical Medicine. Current projects with international partners including University of Oxford (UK), University of Dundee (UK), University of Bangor (UK), Ohio State University (EUA), Universität Munster (Alemanha), Universidad San Pablo (Espanha), University of Auckland (NZ). From 2011-2014 coordinated a Drug Discovery project with GlaxoSmithKline (UK). Field of interest- Drug Discovery (natural products and synthetic compounds) for Leishmaniasis and Chagas disease, with emphasis on pre-clinical studies of drugs, mechanism of action, drug repositioning, combination therapy and marine microbiology. Integrates the research network ResNet NPND (Brazil-Germany-Universität Münster) for new drugs against neglected diseases. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| Biocompound from Atlantic Rainforest combats leishmaniasis and Chagas disease |
- Natural metabolites for treating antimicrobial resistant gonorrhoea and visceral leishmaniasis, AP.R
Abstract
Neisseria gonorrhoeae (Ng, gonococcus) is the causative agent of the sexually transmitted disease gonorrhoea and affects 78 million people worldwide. Gonococcal infection is frequently asymptomatic but long-term and/or permanent sequelae can develop in individuals. Effective, accessible and affordable antimicrobial treatment is essential for management and control. However, gonococci ha...
- Selection and optimization of new drug candidates for Leishmaniasis and Chagas Disease, AP.R
Abstract
Considering the morbidity and mortality of visceral leishmaniasis and Chagas' disease, and the therapeutic limitations, these neglected protozoan diseases have been prioritized by WHO. The present proposal aims the search for a new pharmaceutical prototype for each disease, through coordinated activities in Drug Discovery. Based in a multidisciplinary proposal, we propose the continuati...
- Institutional research development plan Adolfo Lutz Institute, AP.PDIP
Abstract
IAL has established itself as a reference institution in Public Health, developing scientific research and performing analytical procedures for diagnostic elucidation and sanitary control, rapidly addressing the demands of Health Surveillance of the different regions of the State of Sao Paulo and other units of the federation. The data regarding the IAL scientific-technical production (...
(Only some records are available in English at this moment)
- Rational pre-clinical study of new drug candidates against neglected protozoan diseases using pharmacokinetic approaches, AP.R
Abstract
Neglected protozoosis as leishmaniasis and Chagas disease, afflict more than 20 million people mainly in developing countries, with a limited, highly toxic and inefficient therapeutic arsenal. Using two approaches in Drug Discovery, as the drug repositioning and combination therapy, this proposal aims to study oral antidepressant drugs, with focus mainly on sertraline, as a potential al...
- Brazilian biodiversity as a source for novel drug scaffolds against neglected protozoan diseases, AP.R
Abstract
Brazilian biodiversity has proved a powerful source of small bioactive molecules, which are valuable lead compounds for the development of useful therapeutics. Based ín these aspects, biodiversity conservation and restoration have been high priorities for ... (AU)
- Natural product-based drug design: novel compounds against Leishmania (L.) infantum, AP.R
Abstract
Natural products in the era of rational drug design still play an important role in the search for new active drugs, representing valuable lead structures that can be developed further into useful therapeutics. Prof. Tempone group together with Prof. João H. G. Lago (UNIFESP) have shown the in vitro potential of natural products gibbilimbol and polygodial from Brazilian plants Piper mal...
(Only some records are available in English at this moment)
- Optimization of natural scaffolds as new therapeutic candidates for Visceral Leishmaniasis, BP.DR
Abstract
Visceral Leishmaniasis is a neglected protozoan disease with high mortality, and the treatment is a serious challenge to public health. Considering that natural products represent a promising source of new pharmaceutical prototypes, this proposal aims to continue the SPRINT:Oxford project (2015/50075-2), attending the research demand in the area of new drugs for VL. It will count on int...
- Selection of new drug candidates in Leishmaniasis, BP.IC
Abstract
Visceral leishmaniasis is a neglected disease that mainly affects developing countries. Available chemotherapy for the treatment of leishmaniasis has a reduced number of drugs, with severe adverse effects and progressive increase of resistance. Drug repositioning consists in the search for new uses for approved drugs and is a great opportunity to introduce new therapies by significantly...
- In vitro study of cellular immune response against synthetic drugs with antileishmanial activities, BP.PD
Abstract
Neglected diseases cause more than 534,000 deaths annually and is prevalent mostly in poor/developing countries. Leishmaniasis fit this frame and cause approximately 2.1 million DALYs (disability-adjusted life year), expressed as the number of years lost due to ill health, disability or early death. Among the various clinical forms that the disease presents, this it is being dependent o...
- Study of the therapeutic potential of drugs and synthetic compounds, free or loaded into NANOLIPOSOMES: an vitro and experimental approach, BP.DR
Abstract
Leishmaniasis is a neglected tropical disease, which includes a spectrum of diseases of varying degrees of severity, resulting from a skin lesion to a progressive fatal visceral infection. The development of new therapies for leishmaniasis is essential due to the limited therapeutic options and the high toxicity of drugs. This project aims to study the in vitro and in experimental model...
- Isolation, characterization, antileishmanial and antitrypanosomal activity of bioactive compounds from brazilian amphibian poisons, BP.MS
Abstract
Among the parasitic infectious diseases, those caused by protozoan parasites are a significant challenge for Public Health and are represented by Leishmaniasis and Chagas disease. It affects mainly the poorest population and thus is not recognized as a potential market. The goal of the present work is to isolate novel natural compounds with antileishmanial and antitrypanosomal activitie...
(Only some records are available in English at this moment)
- Therapeutic potential of drugs entrapped into phosphatidylserine-liposomes: an experimental approach, BE.EP.DR
Abstract
Leishmaniasis is a neglected tropical disease, which includes a diseases spectrum of varying degrees of severity, resulting from a skin lesion to a progressive fatal visceral infection. Estimated at 12 million cases, leishmaniasis affects 98 countries with a limited and toxic therapeutic arsenal. The development of new therapies for leishmaniasis is therefore essential. Liposomes have b...
| 4 / 4 | Ongoing research grants |
| 9 / 8 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 6 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 22 / 20 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 47 |
| Citations | 496 |
| Cit./Article | 10.6 |
| Data from Web of Science | |
PINTO, ERIKA GRACIELLE; ANTONIAZZI, MARTA MARIA; JARED, CARLOS; TEMPONE, ANDRE GUSTAVO. Antileishmanial and antitrypanosomal activity of the cutaneous secretion of Siphonops annulatus. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 20, NOV 24 2014. Web of Science Citations: 5. (09/12236-3, 08/09260-7)
FERREIRA, DAIANE DIAS; MESQUITA, JULIANA TONINI; DA COSTA SILVA, THAIS ALVES; ROMANELLI, MAIARA MARIA; JAEN BATISTA, DENISE DA GAMA; DA SILVA, CRISTIANE FRANCA; SILVA DA GAMA, ALINE NEFERTITI; NEVES, BRUNO JUNIOR; MELO-FILHO, CLEBER CAMILO; CORREIA SOEIRO, MARIA DE NAZARE; et al. Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, OCT 30 2018. Web of Science Citations: 0. (15/23403-9)
REIMAO, JULIANA QUERO; TEMPONE, ANDRE GUSTAVO. Investigation into in vitro anti-leishmanial combinations of calcium channel blockers and current anti-leishmanial drugs. Memórias do Instituto Oswaldo Cruz, v. 106, n. 8, p. 1032-1038, DEC 2011. Web of Science Citations: 8. (08/11434-3, 08/09260-7)
TEMPONE, ANDRE GUSTAVO; TANIWAKI, NOEMI NOSOMI; REIMAO, JULIANA QUERO. Antileishmanial activity and ultrastructural alterations of Leishmania (L.) chagasi treated with the calcium channel blocker nimodipine. Parasitology Research, v. 105, n. 2, p. 499-505, 2009. Web of Science Citations: 28. (08/09260-7)
TEMPONE‚ AG; TREIGER BORBOREMA‚ SE; DE ANDRADE‚ HF; DE AMORIM GUALDA‚ NC; YOGI‚ A.; SALERNO CARVALHO‚ C.; BACHIEGA‚ D.; LUPO‚ FN; BONOTTO‚ SV; FISCHER‚ DCH. Antiprotozoal activity of Brazilian plant extracts from isoquinoline alkaloid-producing families. Phytomedicine, v. 12, n. 5, p. 382-390, 2005.
GEHRKE, SEBASTIAN S.; PINTO, ERIKA G.; STEVERDING, DIETMAR; PLEBAN, KARIN; TEMPONE, ANDRE G.; HIDER, ROBERT C.; WAGNER, GERD K.. Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators. Bioorganic & Medicinal Chemistry, v. 21, n. 3, p. 805-813, FEB 1 2013. Web of Science Citations: 12. (11/50577-7)
PINTO, ERIKA G.; SANTOS, ISABELA O.; SCHMIDT, THOMAS J.; BORBOREMA, SAMANTA E. T.; FERREIRA, VITOR F.; ROCHA, DAVID R.; TEMPONE, ANDRE G.. Potential of 2-Hydroxy-3-Phenylsulfanylmethyl-[1,4]-Naphthoquinones against Leishmania (L.) infantum: Biological Activity and Structure-Activity Relationships. PLoS One, v. 9, n. 8, AUG 29 2014. Web of Science Citations: 32. (11/23703-1, 12/18756-1)
PINTO, ERIKA G.; DA COSTA-SILVA, THAIS A.; TEMPONE, ANDRE GUSTAVO. Histamine H1-receptor antagonists against Leishmania (L.) infantum: an in vitro and in vivo evaluation using phosphatidylserine-liposomes. Acta Tropica, v. 137, p. 206-210, SEP 2014. Web of Science Citations: 10. (11/23703-1, 12/18756-1)
REIMAO, JULIANA QUERO; MESQUITA, JULIANA TONINI; FERREIRA, DAIANE DIAS; TEMPONE, ANDRE GUSTAVO. Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. Evidence-based Complementary and Alternative Medicine, 2016. Web of Science Citations: 1. (08/11434-3, 12/18756-1, 11/21970-2)
SANTOS, LUCIANA DE A.; CAVALHEIRO, ALBERTO J.; TEMPONE, ANDRE G.; CORREA, DANIELA S.; ALEXANDRE, TATIANA R.; QUINTILIANO, NATALIA F.; RODRIGUES-OLIVEIRA, ANDRE F.; OLIVEIRA-SILVA, DIOGO; MARTINS, ROBERTO CARLOS C.; LAGO, JOAO HENRIQUE G.. Antitrypanosomal Acetylene Fatty Acid Derivatives from the Seeds of Porcelia macrocarpa (Annonaceae). Molecules, v. 20, n. 5, p. 8168-8180, MAY 2015. Web of Science Citations: 4. (11/51739-0, 12/18756-1)
MESQUITA, JULIANA TONINI; DA COSTA-SILVA, THAIS ALVES; TREIGER BORBOREMA, SAMANTA ETEL; TEMPONE, ANDRE GUSTAVO. Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole. Molecular and Cellular Biochemistry, v. 389, n. 1-2, p. 293-300, APR 2014. Web of Science Citations: 19. (12/18756-1)
REIMAO, JULIANA QUERO; MIGOTTO, ALVARO ESTEVES; KOSSUGA, MIRIAM H.; BERLINCK, ROBERTO G. S.; TEMPONE, ANDRE GUSTAVO. Antiprotozoan activity of Brazilian marine cnidarian extracts and of a modified steroid from the octocoral Carijoa riisei. Parasitology Research, v. 103, n. 6, p. 1445-1450, NOV 2008. Web of Science Citations: 26. (06/05241-2, 05/00974-9, 05/60175-2)
DA COSTA-SILVA, THAIS ALVES; GALISTEO, JR., ANDRES JIMENEZ; LAULETTA LINDOSO, JOSE ANGELO; BARBOSA, LEANDRO R. S.; TEMPONE, ANDRE GUSTAVO. Nanoliposomal Buparvaquone Immunomodulates Leishmania infantum-Infected Macrophages and Is Highly Effective in a Murine Model. Antimicrobial Agents and Chemotherapy, v. 61, n. 4, APR 2017. Web of Science Citations: 6. (13/50228-8, 13/07275-5, 15/15822-1, 15/23403-9)
BAPTISTA CANUTO, GISELE ANDRE; DORR, FABIANE; GHILARDI LAGO, JOAO HENRIQUE; TEMPONE, ANDRE GUSTAVO; PINTO, ERNANI; PIMENTA, DANIEL CARVALHO; SIMON FARAH, JOAO PEDRO; MANSO ALVES, MARIA JULIA; MAGGI TAVARES, MARINA FRANCO. New insights into the mechanistic action of methyldehydrodieugenol B towards Leishmania (L.) infantum via a multiplatform based untargeted metabolomics approach. METABOLOMICS, v. 13, n. 5, MAY 2017. Web of Science Citations: 2. (14/25494-9, 12/18756-1, 12/04601-6, 15/50075-2, 12/07361-6)
VARELA, MARINA T.; DIAS, ROBERTO Z.; MARTINS, LIGIA F.; FERREIRA, DAIANE D.; TEMPONE, ANDRE G.; UENO, ANDERSON K.; LAGO, JOAO HENRIQUE G.; FERNANDES, JOAO PAULO S.. Gibbilimbol analogues as antiparasitic agents-Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum. Bioorganic & Medicinal Chemistry Letters, v. 26, n. 4, p. 1180-1183, FEB 15 2016. Web of Science Citations: 9. (15/11936-2, 14/16564-3, 12/18756-1, 13/20479-9)
GRECCO, SIMONE S.; COSTA-SILVA, THAIS A.; JERZ, GEROLD; DE SOUSA, FERNANDA S.; ALVES CONSERVA, GEANNE A.; MESQUITA, JULIANA T.; GALUPPO, MARIANA K.; TEMPONE, ANDRE G.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; et al. Antitrypanosomal activity and evaluation of the mechanism of action of dehydrodieugenol isolated from Nectandra leucantha (Lauraceae) and its methylated derivative against Trypanosoma cruzi. Phytomedicine, v. 24, p. 62-67, JAN 15 2017. Web of Science Citations: 7. (15/11936-2, 13/07275-5)
GRECCO, SIMONE S.; COSTA-SILVA, THAIS A.; JERZ, GEROLD; DE SOUSA, FERNANDA S.; LONDERO, VINICIUS S.; GALUPPO, MARIANA K.; LIMA, MARTA L.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; TEMPONE, ANDRE G.; et al. Neolignans from leaves of Nectandra leucantha (Lauraceae) display in vitro antitrypanosomal activity via plasma membrane and mitochondrial damages. Chemico-Biological Interactions, v. 277, p. 55-61, NOV 1 2017. Web of Science Citations: 7. (15/11936-2, 13/50228-8, 15/50075-2)
UENO, ANDERSON K.; BARCELLOS, ALINE F.; COSTA-SILVA, THAIS A.; MESQUITA, JULIANA T.; FERREIRA, DAIANE D.; TEMPONE, ANDRE G.; ROMOFF, PAULETE; ANTAR, GUILHERME M.; LAGO, JOAO HENRIQUE G.. Antitrypanosomal activity and evaluation of the mechanism of action of diterpenes from aerial parts of Baccharis retusa (Asteraceae). Fitoterapia, v. 125, p. 55-58, MAR 2018. Web of Science Citations: 7. (15/11936-2, 14/08961-2, 15/23403-9)
VARELA, MARINA T.; ROMANELI, MAIARA M.; LIMA, MARTA L.; BORBOREMA, SAMANTA E. T.; TEMPONE, ANDRE G.; FERNANDES, JOAO P. S.. Antiparasitic activity of new gibbilimbol analogues and SAR analysis through efficiency and statistical methods. European Journal of Pharmaceutical Sciences, v. 122, p. 31-41, SEP 15 2018. Web of Science Citations: 3. (16/00195-4, 16/25028-3, 15/23403-9)
ALVES CONSERVA, GEANNE A.; DA COSTA-SILVA, THAIS A.; AMARAL, MAIARA; ANTAR, GUILHERME M.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G.. Butenolides from Nectandra oppositifolia (Lauraceae) displayed anti-Trypanosoma cruzi activity via deregulation of mitochondria. Phytomedicine, v. 54, p. 302-307, FEB 15 2019. Web of Science Citations: 1. (16/20633-6, 18/07885-1, 15/23403-9)
LIMA, MARTA L.; ROMANELLI, MAIARA M.; BORBOREMA, SAMANTA E. T.; JOHNS, DEIDRE M.; MIGOTTO, ALVARO ESTEVES; LAGO, JOAO HENRIQUE G.; TEMPONE, ANDRE G.. Antitrypanosomal activity of isololiolide isolated from the marine hydroid Macrorhynchia philippina (Cnidaria, Hydrozoa). BIOORGANIC CHEMISTRY, v. 89, AUG 2019. Web of Science Citations: 1. (18/10279-6)
MORAIS, THIAGO R.; COSTA-SILVA, THAIS A.; FERREIRA, DAIANE D.; NOVAIS, BIANCA J.; TORRECILHAS, ANA CLAUDIA T.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G.. Antitrypanosomal activity and effect in plasma membrane permeability of (-)-bornyl p-coumarate isolated from Piper cernuum (Piperaceae). BIOORGANIC CHEMISTRY, v. 89, AUG 2019. Web of Science Citations: 0. (18/10279-6, 18/07885-1)
VARELA, MARINA T.; COSTA-SILVA, THAIS A.; LAGO, JOAO HENRIQUE G.; TEMPONE, ANDRE G.; FERNANDES, JOAO PAULO S.. Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives. BIOORGANIC CHEMISTRY, v. 89, AUG 2019. Web of Science Citations: 0. (18/03918-2, 16/25028-3, 18/07885-1, 15/23403-9)
REIMAO, JULIANA Q.; COLOMBO, FABIO A.; PEREIRA-CHIOCCOLA, VERA L.; TEMPONE, ANDRE G.. Effectiveness of liposomal buparvaquone in an experimental hamster model of Leishmania (L.) infantum chagasi. Experimental Parasitology, v. 130, n. 3, p. 195-199, MAR 2012. Web of Science Citations: 27. (08/11434-3, 08/09260-7)
TEMPONE, ANDRE GUSTAVO; PIMENTA, DANIEL CARVALHO; LEBRUN, IVO; SARTORELLI, PATRICIA; TANIWAKI, NOEMI N.; DE ANDRADE, JR., HEITOR FRANCO; ANTONIAZZI, MARTA MARIA; JARED, CARLOS. Antileishmanial and antitrypanosomal activity of bufadienolides isolated from the toad Rhinella jimi parotoid macrogland secretion. Toxicon, v. 52, n. 1, p. 13-21, JUL 2008. Web of Science Citations: 70. (05/00974-9)
TEMPONE, ANDRE GUSTAVO; MORTARA, RENATO ARRUDA; DE ANDRADE, JR., HEITOR FRANCO; REIMAO, JULIANA QUERO. Therapeutic evaluation of free and liposome-loaded furazolidone in experimental visceral leishmaniasis. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v. 36, n. 2, p. 159-163, AUG 2010. Web of Science Citations: 19. (08/09260-7)
REIMAO, JULIANA Q.; SCOTTI, MARCUS T.; TEMPONE, ANDRE G.. Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study. Bioorganic & Medicinal Chemistry, v. 18, n. 22, p. 8044-8053, NOV 15 2010. Web of Science Citations: 41. (08/11434-3, 08/09260-7)
MARTINS, LIGIA F.; MESQUITA, JULIANA T.; PINTO, ERIKA G.; COSTA-SILVA, THAIS A.; BORBOREMA, SAMANTA E. T.; GALISTEO JUNIOR, ANDRES J.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; AL SHUHAIB, ZAINAB; BENNETT, ELLIOT L.; et al. Analogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular Amastigotes. Journal of Natural Products, v. 79, n. 9, p. 2202-2210, SEP 2016. Web of Science Citations: 18. (11/23703-1, 13/50228-8, 13/07275-5, 12/18756-1)
LONDERO, VINICIUS S.; DA COSTA-SILVA, THAIS A.; GOMES, KAIO S.; FERREIRA, DAIANE D.; MESQUITA, JULIANA T.; TEMPONE, ANDRE G.; YOUNG, MARIA CLAUDIA M.; JERZ, GEROLD; LAGO, JOAO HENRIQUE G.. Acetylenic fatty acids from Porcelia macrocarpa (Annonaceae) against trypomastigotes of Trypanosoma cruzi: Effect of octadec-9-ynoic acid in plasma membrane electric potential. BIOORGANIC CHEMISTRY, v. 78, p. 307-311, AUG 2018. Web of Science Citations: 2. (15/23403-9)
CUNHA-JUNIOR, EDEZIO FERREIRA; ANDRADE-NETO, VALTER VIANA; LIMA, MARTA LOPES; DA COSTA-SILVA, THAIS ALVES; GALISTEO JUNIOR, ANDRES J.; ABENGOZAR, MARIA A.; BARBAS, CORAL; RIVAS, LUIS; ALMEIDA-AMARAL, ELMO EDUARDO; TEMPONE, ANDRE GUSTAVO; et al. Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice. PLoS Neglected Tropical Diseases, v. 11, n. 1, JAN 2017. Web of Science Citations: 7. (15/23403-9)
WULSTEN, IMKE E.; COSTA-SILVA, THAIS A.; MESQUITA, JULIANA T.; LIMA, MARTA L.; GALUPPO, MARIANA K.; TANIWAKI, NOEMI N.; BORBOREMA, SAMANTA E. T.; DA COSTA, FERNANDO B.; SCHMIDT, THOMAS J.; TEMPONE, ANDRE G.. Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones. Molecules, v. 22, n. 5, MAY 2017. Web of Science Citations: 7. (13/50228-8, 12/18756-1)
TEMPONE, ANDRE GUSTAVO; FERREIRA, DAIANE DIAS; LIMA, MARTA LOPES; COSTA SILVA, THAIS ALVES; BORBOREMA, SAMANTA E. T.; REIMAO, JULIANA QUERO; GALUPPO, MARIANA K.; GUERRA, JULIANA MARIOTTI; RUSSELL, ANGELIE J.; WYNNE, GRAHAM M.; et al. Efficacy of a series of alpha-pyrone derivatives against Leishmania (L.) infantum and Trypanosoma cruzi. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 139, p. 947-960, OCT 20 2017. Web of Science Citations: 14. (13/07275-5, 15/50075-2, 15/23403-9)
VARELA, MARINA T.; LIMA, MARTA L.; GALUPPO, MARIANA K.; TEMPONE, ANDRE G.; DE OLIVEIRA, ALBERTO; LAGO, JOAO HENRIQUE G.; FERNANDES, JOAO PAULO S.. New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum. CHEMICAL BIOLOGY & DRUG DESIGN, v. 90, n. 5, p. 1007-1011, NOV 2017. Web of Science Citations: 8. (15/11936-2, 13/50228-8, 16/00195-4, 12/18756-1)
PINTO, ERIKA GRACIELLE; PIMENTA, DANIEL C.; ANTONIAZZI, MARTA MARIA; JARED, CARLOS; TEMPONE, ANDRE GUSTAVO. Antimicrobial peptides isolated from Phyllomedusa nordestina (Amphibia) alter the permeability of plasma membrane of Leishmania and Trypanosoma cruzi. Experimental Parasitology, v. 135, n. 4, p. 655-660, DEC 2013. Web of Science Citations: 23. (09/12236-3, 08/09260-7)
MESQUITA, JULIANA TONINI; PINTO, ERIKA GRACIELLE; TANIWAKI, NOEMI NOSOMI; GALISTEO, JR., ANDRES JIMENEZ; TEMPONE, ANDRE GUSTAVO. Lethal action of the nitrothiazolyl-salicylamide derivative nitazoxanide via induction of oxidative stress in Leishmania (L.) infantum. Acta Tropica, v. 128, n. 3, p. 666-673, DEC 2013. Web of Science Citations: 11. (12/18756-1)
DA COSTA-SILVA, THAIS ALVES; GRECCO, SIMONE S.; DE SOUSA, FERNANDA S.; LAGO, JOAO HENRIQUE G.; MARTINS, EUDER G. A.; TERRAZAS, CESAR A.; VARIKUTI, SANJAY; OWENS, KATHERINE L.; BEVERLEY, STEPHEN M.; SATOSKAR, ABHAY R.; et al. Immunomodulatory and Antileishmanial Activity of Phenylpropanoid Dimers Isolated from Nectandra leucantha. Journal of Natural Products, v. 78, n. 4, p. 653-657, APR 2015. Web of Science Citations: 25. (13/50318-7, 12/18756-1, 13/07275-5)
MORAIS, THIAGO R.; DA COSTA-SILVA, THAIS A.; TEMPONE, ANDRE G.; BORBOREMA, SAMANTA ETEL T.; SCOTTI, MARCUS T.; DE SOUSA, RAQUEL MARIA F.; ARAUJO, ANA CAROLINA C.; DE OLIVEIRA, ALBERTO; DE MORAIS, SERGIO ANTONIO L.; SARTORELLI, PATRICIA; et al. Antiparasitic Activity of Natural and Semi-Synthetic Tirucallane Triterpenoids from Schinus terebinthifolius (Anacardiaceae): Structure/Activity Relationships. Molecules, v. 19, n. 5, p. 5761-5776, MAY 2014. Web of Science Citations: 8. (11/51739-0, 12/18756-1, 13/16320-4)
REIMAO, JULIANA Q.; COLOMBO, FABIO A.; PEREIRA-CHIOCCOLA, VERA L.; TEMPONE, ANDRE G.. In vitro and experimental therapeutic studies of the calcium channel blocker bepridil.: Detection of viable Leishmania (L.) chagasi by real-time PCR. Experimental Parasitology, v. 128, n. 2, p. 111-115, JUN 2011. Web of Science Citations: 24. (08/11434-3, 08/00520-6, 08/09260-7)
OLIVEIRA, EMERSON A.; BRITO, IVANILDO A.; LIMA, MARTA L.; ROMANELLI, MAIARA; MOREIRA-FILHO, JOSE T.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; SARTORELLI, PATRICIA; TEMPONE, ANDRE G.; COSTA-SILVA, THAIS A.; et al. Antitrypanosomal Activity of Acetogenins Isolated from the Seeds of Porcelia macrocarpa Is Associated with Alterations in Both Plasma Membrane Electric Potential and Mitochondrial Membrane Potential. Journal of Natural Products, v. 82, n. 5, p. 1177-1182, MAY 2019. Web of Science Citations: 0. (18/10279-6, 18/07885-1)
MENDES, VIVIANE DE MELO; TEMPONE, ANDRE GUSTAVO; TREIGER BORBOREMA, SAMANTA ETEL. Antileishmanial activity of Hi-antihistamine drugs and cellular alterations in Leishmania (L.) infantum. Acta Tropica, v. 195, p. 6-14, JUL 2019. Web of Science Citations: 0. (18/10279-6, 14/24908-4)
LIMA, MARTA L.; ABENGOZAR, MARIA A.; NACHER-VAZQUEZ, MONTSERRAT; MARTINEZ-ALCAZAR, MARIA P.; BARBAS, CORAL; TEMPONE, ANDRE G.; LOPEZ-GONZALVEZ, ANGELES; RIVAS, LUIS. Molecular Basis of the Leishmanicidal Activity of the Antidepressant Sertraline as a Drug Repurposing Candidate. Antimicrobial Agents and Chemotherapy, v. 62, n. 12, DEC 2018. Web of Science Citations: 2. (15/23403-9)
GOMES, KAIO S.; DA COSTA-SILVA, THAIS A.; OLIVEIRA, IGOR H.; AGUILAR, ANDREA M.; OLIVEIRA-SILVA, DIOGO; UEMI, MIRIAM; SILVA, WENDER A.; MELO, LENNINE R.; ANDRADE, CARLOS KLEBER Z.; TEMPONE, ANDRE G.; et al. Structure-activity relationship study of antitrypanosomal chalcone derivatives using multivariate analysis. Bioorganic & Medicinal Chemistry Letters, v. 29, n. 12, p. 1459-1462, JUN 15 2019. Web of Science Citations: 0. (18/10279-6, 18/07885-1)
ERIKA G. PINTO; ANDRE G. TEMPONE. Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, p. -, 2018. (15/23403-9)
AMARAL, MAIARA; DE SOUSA, FERNANDA S.; SILVA, THAIS A. COSTA; JUNIOR, ANDRES JIMENEZ G.; TANIWAKI, NOEMI N.; JOHNS, DEID RE M.; LAGO, JOAO HENRIQUE G.; ANDERSON, EDWARD A.; TEMPONE, ANDRE G.. A semi-synthetic neolignan derivative from dihydrodieugenol B selectively affects the bioenergetic system of Leishmania infantum and inhibits cell division. SCIENTIFIC REPORTS, v. 9, APR 16 2019. Web of Science Citations: 1. (18/10279-6, 15/50075-2, 18/07885-1)
GUIMARAES GONCALVES, GIULIA ELISA; MORAIS, THIAGO RAHAL; GOMES, KAIO DE SOUZA; COSTA-SILVA, THAIS ALVES; TEMPONE, ANDRE GUSTAVO; GHILARDI LAGO, JOAO HENRIQUE; CASELI, LUCIANO. Antitrypanosomal activity of epi-polygodial from Drimys brasiliensis and its effects in cellular membrane models at the air-water interface. BIOORGANIC CHEMISTRY, v. 84, p. 186-191, MAR 2019. Web of Science Citations: 0. (15/23446-0, 13/14262-7, 18/07885-1, 15/23403-9)
DA COSTA-SILVA, THAIS A.; ALVES CONSERVA, GEANNE A.; GALISTEO, JR., ANDRES J.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G.. Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae). Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, AUG 19 2019. Web of Science Citations: 0. (16/20633-6, 18/10279-6, 18/07885-1)
BRITO, JULIANA R.; DA COSTA-SILVA, THAIS A.; TEMPONE, ANDRE G.; FERREIRA, EDGARD A.; LAGO, JOAO HENRIQUE G.. Dibenzylbutane neolignans from Saururus cernuus L. (Saururaceae) displayed anti-Trypanosoma cruzi activity via alterations in the mitochondrial membrane potential. Fitoterapia, v. 137, SEP 2019. Web of Science Citations: 0. (18/10279-6, 18/07885-1)
GRECCO, SIMONE S.; COSTA-SILVA, THAIS A.; SOUSA, FERNANDA S.; CARGNELUTTI, STEFANO B.; UMEHARA, ERIC; MENDONCA, POLIANA S.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G.. Neolignans isolated from twigs of Nectandra leucantha Ness & Mart (Lauraceae) displayed in vitro antileishmanial activity. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, SEP 27 2018. Web of Science Citations: 0. (18/07885-1, 15/23403-9)
FERREIRA, DAIANE D.; SOUSA, FERNANDA S.; COSTA-SILVA, THAIS A.; REIMAO, JULIANA Q.; TORRECILHAS, ANA C.; JOHNS, DEIDRE M.; SEAR, CLAIRE E.; HONORIO, KATHIA M.; LAGO, JOAO HENRIQUE G.; ANDERSON, EDWARD A.; et al. Dehydrodieugenol B derivatives as antiparasitic agents: Synthesis and biological activity against Trypanosoma cruzi. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 176, p. 162-174, AUG 15 2019. Web of Science Citations: 1. (18/10279-6, 16/24524-7, 15/50075-2, 18/07885-1)