bachelor's at Ciências Biológicas from Universidade Federal de São Carlos (1992), master's at Applied Imunology from Universidade de São Paulo (1995) and doctorate at Applied Imunology from Universidade de São Paulo (1999). Has experience in Immunology, focusing on Immunology, acting on the following subjects: mycobacterium tuberculosis, linfócitos t, vacina de dna, interleucina-4 and interferon gama. (Source: Lattes Curriculum)
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Comorbidities are one of the factors related to the development of more severe forms of asthma and tuberculosis. Both diseases are immuno-mediated (immunopathologies), characterized by exacerbation of pulmonary inflammation, but triggered by different effector mechanisms. The Subprojects contained in this Proposal have a clear objective: to determine mechanisms that exacerbate pulmonary i…
Comorbidities are one of the factors related to the development of more severe forms of asthma and tuberculosis. Both diseases are immuno-mediated (immunopathologies), characterized by exacerbation of pulmonary inflammation, but triggered by different effector mechanisms. The Subprojects contained in this proposal have a clear objective: to determine mechanisms that exacerbate pulmonary i…
2019-nCoV infection results in pneumonia marked by intense inflammation. There is still no specific treatment for COVID-19 disease. The fact that 2019-nCoV infection causes intense pathological inflammation shows that surviving the infection is more a matter of tolerating lung damage (damage tolerance) than properly controlling the load viral (pathogen tolerance). New perspectives for the…
This project is based on two distinct goals. The first one is to strengthen our research group. The multidisciplinary nature and its technical and scientific approaches result in the congregation of a large group of scientists, which already interact regularly. The project works with a strong graduate program, being that the maintenance of the animal roons, the flow cytometry, and general…
In our laboratory we have used animals which have different ability to generate Th1 immune responses and distinct ability to controlling Mycobacterium tuberculosis infection with the aim to characterize immunological factors and mechanisms involved in the regulation of immune response. Our results show that BALB/c mice, which do not control infection at the late phase (70 days), had down …
(Only some records are available in English at this moment)
Tuberculosis is a heterogeneous disease that is influenced by genetic factors of the infected host, the strain of mycobacteria, social and economic factors, and comorbidities. Among the comorbidities, obesity and diabetes increase the susceptibility to developing the disease.Initially and based on the literature, I started from the hypothesis that the inflammatory response resulting from …
Obesity comprises a risk factor to Asthma exacerbation through neutrophilic inflammation, which characterizes a phenotype of severe Asthma. However, the mechanisms involved in exacerbation of lung inflammation in the comorbidity Asthma and Obesity is unknown. The adipokine chemerin is increase in the serum of obese patients and several works have demonstrate the role of chemerin in the in…
The asthma is a chronic disease of the world reach, causing inflammation and remodeling in the lung tissue. Recent studies suggest what the inflammation causing of the asthma has systemic effect, affecting the central neurvous system (CNS). The inflammation response in the lung of patient with allergic asthma or Th2 high is characterized by the presence of IL-4, IL-5, IL-13. This cytokine…
Rhinoviruses (RVs) is the main cause of the "common cold". However, RV infections also aggravate respiratory diseases, accounting for 80% of asthma exacerbations in children and 50% of episodes in adults. Although epidemiological data associates this viral infection with asthma crisis, the mechanisms by which the infection triggers these exacerbations have not yet been fully elucidated. R…
Obesity is a risk factor for asthma worsening, a lung chronic inflammatory disease that affects about 334 million people worldwide. Comorbidity asthma and obesity is characterized by neutrophil infiltration in the airways, which is associated with a severe asthma phenotype with low responsiveness to corticosteroids. The mechanisms involved in the asthma exacerbation that occurs with obesi…
(Only some records are available in English at this moment)
Obesity is a risk factor to asthma exacerbation. Obese and asthmatic individuals have a poor responsiveness to corticosteroid treatment as consequences of neutrophil and Th17 cell influx to the lungs. Gut dysbiosis is a hallmark of obesity and it is related to asthma susceptibility and exacerbation. Endothelial glycocalyx (EG) is a network of proteoglycans and glycoproteins anchored in en…
Asthma is a complex and heterogeneous disease. While allergic asthma, generally defined as mild asthma, is characterized by IgE production, Th2 cell activation and eosinophil recruitment, non-allergic asthma, defined as moderate-severe asthma, is characterized by Th17 cell activation and mixed recruitment of eosinophils and neutrophils. Viruses, bacterial infections and pollutants are fac…
| 2 / 2 | Ongoing grants |
| 8 / 7 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 25 / 17 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 39 / 30 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID