CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Science, Area Biomedicine at Universidade Estadual de Londrina (1980), master's degree in Molecular Biology (1984) and Doctorate /PhD in Microbiology and Immunology at Federal University of Sao Paulo (UNIFESP) (1988), post-doctoral training at Tufts University (1989-1990), Boston, MA, under supervision of Dr Charles Dinarello, and Stanford University (1991-1992), Stanford, CA, USA, under supervision of Dr Steven Sherwood. Has experience in Biochemistry, Cell and Molecular Biology and Immunology. He is co-discover the Dermcidin, an antibiotic peptide, with multiple biological functions, which is produced by eccrine glands and relased in the sweat and other biological fluids. His work is focused on the role of dermcidin as oncogene for skin cancer and breast cancer through its modulation of cell death pathways (apoptosis and necrosis), antimicrobial activity, anti-inflammation activity and immune-modulating properties on the innate and adaptive responses. He is a professor at the multicenter postgraduate program in Biochemistry and Molecular Biology at the School of Arts, Sciences and Humanities (EACH) at the University of São Paulo. He is a partner and co-founder of the startup Crixpir Biotecnologia Ltda. (Source: Lattes Curriculum)
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With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set of tools to accurately predict signaling network and clinical outcomes. H…
The human body is the residence of a large number of commensal (non-pathogenic) and pathogenic microbial species that have co-evolved with the human genome, adaptive immune system and diet. With recent advances in DNA-based technologies, we initiated the exploration of bacterial gene functions and their role in human health. The main goal of the human microbiome project is to characterize…
(Only some records are available in English at this moment)
Cutaneous melanoma is a skin neoplasm with greater mortality and great unpredictability in its evolution. In disseminated disease, treatment options are ineffective. The search for new tumor markers may allow the prediction of evolution, a better understanding of the pathogenesis of melanoma and enables the discovery of molecular targets. The DCD protein is one of the 200 genes to identi…
The protein dermicidina (DCD) is encoded by a gene localized in chromosome 12q13.1 portion 12, present only in primates and humans. The protein is secreted by exocrine cells of the skin melanocytes, neurons and epithelial cells of normal breast. Some studies have shown the importance of protein in oncogenic processes in DCD with breast, prostate and melanoma, revealed by its role as a gro…
The dermicidina (DCD) is a protein encoded by a gene located on loci 12q13.1 of chromossome 12 of primates and humans. The precursor of 11 kDa and their peptides are produced by cells of eccrine glands of the skin, melanocytes, neurons and epithelial cells of breast and placenta. Studies in our laboratory showed that the superexpression od DCD gene or stimulation of cells with recombinan…
(Only some records are available in English at this moment)
| 17 / 13 | Completed research grants |
| 12 / 4 | Completed scholarships in Brazil |
| 29 / 17 | All research grants and scholarships |
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