graduate at Educação Física from FACULDADE DE EDUCAÇÃO FÍSICA - MACKENZIE (2004) and master's at Biologia Celular e Tecidual from Instituto de Ciências Biomédicas da Universidade de São Paulo (2008). Has experience in Fitness, focusing on Fitness, acting on the following subjects: treinamento aeróbio, treinamento aeróbio, ciclo estral, consumo energét, competencia profissional, cla and fígado. (Source: Lattes Curriculum)
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The principal aim of the project is to examine how regular physical exercise impacts immunometabolic profiles and how these changes influence the function of natural killer (NK) cells. Through comprehensive analysis of metabolic pathways, gene expression patterns, and functional assays, we aim to reveal the specific metabolic adaptations and remodelling processes in NK cells that contribu…
Tumorigenesis involves profound changes in intracellular mechanisms in different tissues,including metabolic disturbance, disruption of cell cycle, and resistance to apoptosis, being closelyrelated to external factors, such as smoking, alcoholism and lifestyle. The higher prevalence ofcancer in elderly individuals points to an immunosenescence role. Antitumor events are triggeredby natura…
Background: different long-lasting (>3months) physical and mental disorders, such as pain, fatigue and depression, and cognitive impairment may be triggered by coranavirus infection (ProjectCovid data). Transcranial direct current stimulation (tDCS), an easy-to-apply, nonpharmacology, and safe technique, have been used to attenuate these disorders caused by other disease. Our hypothesis i…
Monocytes are blood cells of the immune system, when infiltrating tissues are distinguished in macrophages M1 or M2, linked to a pro or anti-inflammatory activity, respectively. The M1 phenotype is predominant in white adipose tissue (TAB) of obese subjects, it participates directly in the release of proinflammatory cytokines during the process of chronic inflammation of low grade and exh…
The brain-derived neurotrophic factor (BDNF) is known to be related to neuroprotection and neurogenesis, as well as being involved in cognition, mood, cardiovascular function and energy metabolism. BDNF plays "cross-talk" between the nervous system and immune system, which BDNF signaling pathway in lymphocytes could reflect at least in part, the same signal in the cortex, and this relatio…
(Only some records are available in English at this moment)
Sex hormones are known to interact with the immune system on multiple levels given that sex hormone receptors (SHRs) have been found in several types of immune cells including mononuclear cells, such as monocytes. Nonetheless, it is not clear how the level of physical fitness may control the inflammatory response in women at different stages of their reproductive life. In this sense, info…
Immunosenescence is the progressive dysfunction of the immune system that occurs with aging and results in greater susceptibility to infections, autoimmune diseases, and cancer. There is evidence that exercise is a safe intervention to reduce immunosenescence. The purpose of this study is to explore the effects of lifelong exercise on several markers of immunosenescence and inflammation w…
A adolescência representa um período crítico para estabelecer hábitos de saúde ao longo da vida, como a rotina de exercícios físicos. O exercício durante o crescimento desempenha um papel importante em diferentes sistemas fisiológicos, incluindo o sistema imunológico. Períodos prolongados de inatividade física podem levar a uma diminuição na função das células imunológicas, prejudicando a…
Preliminary studies indicate that physically active individuals have a better response to the SARS-CoV-2 compared to sedentary ones, although the long-term effects of virus on the inflammatory, metabolic, cardiovascular and mental health profile are lacking in better and complete knowledge. Additionally, overweight and obesity are consistently associated with more severe forms of manifest…
During the period of the COVID-19 pandemic, studies have shown a high rate of sedentary behavior, physical inactivity, mood disorders, and reduced sleep quality, in parallel with a reduction in physical exercise. The importance of physical exercise for the maintenance of physical and mental health is well established in the literature, exerting positive effects in the treatment of cogniti…
(Only some records are available in English at this moment)
The major aim of this study is to explore the mechanisms involved in the metabolic programming of CD4+ T cells dependent on regular exercise as a potential determinant for better immune function. The questions that we propose to address in this proposal are:1) Does metabolic preferences of CD4+T cells change over time (from adolescence to old age) and explain their functionality changes? …
The major aim of this study is to investigate the immunometabolic mechanisms of the antitumoral effects of NK cells in individuals engaged in lifelong exercise. The question that we propose to address is this proposal is: Can regular physical exercise create a metabolic and immune environment that suppresses tumorigenesis? We hypothesized that exercise-induced delay in immunosenescence, s…
Derived from a myeloid lineage in the bone marrow, monocytes are blood cells of the immune system that in tissues differentiate into macrophages with an anti-inflammatory (M2) or pro-inflammatory (M1) state. The polarization of macrophages to the inflammatory state in metabolic disorder, or repair in tissue and systemic homeostatic situations, is well established in the literature, showin…
The level of cardiorespiratory fitness is considered a potential modifier of the inverse association between visceral obesity and mortality. Combined with this factor, low-grade inflammation promotes insulin resistance and adiponectin as well as dysregulation of the adaptive immune system such as T lymphocytes. The energy demand of T lymphocytes is regulated by nutrient sensors such as mT…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 9 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 21 / 20 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 8 / 8 | Completed scholarships abroad |
| 43 / 39 | All research grants and scholarships |
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CV Lattes
ORCID