CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Faculdade de Ciências e Tecnologia (FCT) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Educação Física from FACULDADE DE EDUCAÇÃO FÍSICA - MACKENZIE (2004) and master's at Biologia Celular e Tecidual from Instituto de Ciências Biomédicas da Universidade de São Paulo (2008). Has experience in Fitness, focusing on Fitness, acting on the following subjects: treinamento aeróbio, treinamento aeróbio, ciclo estral, consumo energét, competencia profissional, cla and fígado. (Source: Lattes Curriculum)
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Obesity is a chronic inflammatory condition associated with insulin resistance, liver dysfunction, and increased risk of neoplasms. This project proposes a clinical and translational approach to investigate the effects of bariatric surgery on systemic inflammation, liver metabolism, and the immunometabolic role of adipose tissue.In the clinical component, patients with obesity will be eva…
The association between sedentary behavior, physical inactivity and high caloric intake favors the accumulation of fat in the central region, increasing the risk of developing non-communicable chronic diseases. In addition, this condition affects the neuro-immune axis, impacting macrophage ¿-adrenergic signaling, and mitochondrial metabolism, favoring polarization toward a persistent infl…
Our proposal is the creation of the Multiprofessional Center for Paralympic and Para-sport Studies (CMEPP): Health, Education, High Performance, and Technology. We believe that CMEPP can generate a significant impact on the development of Paralympic and para-sports, based on four guiding pillars: Health, Education, High Performance, and Technology. We understand that these areas have the …
Central adiposity and poor cardiorespiratory fitness are modifiable risk factors for variousdiseases. This study investigated their impact on CD4+ differentiated T regulatory (Treg) cellresponses. Thirty-nine young adults were classified into high cardiorespiratory fitness/lowvisceral adipose tissue (High V ¿ O2-Low VAT, n=20) and low cardiorespiratory fitness/highV AT (Low V ¿ O2-High VA…
The principal aim of the project is to examine how regular physical exercise impacts immunometabolic profiles and how these changes influence the function of natural killer (NK) cells. Through comprehensive analysis of metabolic pathways, gene expression patterns, and functional assays, we aim to reveal the specific metabolic adaptations and remodelling processes in NK cells that contribu…
Tumorigenesis involves profound changes in intracellular mechanisms in different tissues,including metabolic disturbance, disruption of cell cycle, and resistance to apoptosis, being closelyrelated to external factors, such as smoking, alcoholism and lifestyle. The higher prevalence ofcancer in elderly individuals points to an immunosenescence role. Antitumor events are triggeredby natura…
(Only some records are available in English at this moment)
Although there is data on the metabolic profile of individuals with different body compositions (normal weight compared with overweight and obese) and cardiorespiratory fitness levels (low and high VO¿max), little is known about the metabolic and inflammatory responses following an acute high-intensity exercise session. In this context, the aim of the present study is to investigate the e…
Our proposal is the creation of the Multiprofessional Center for Paralympic and Parasport Studies (CMEPP): Health, Education, High Performance, and Technology. We believe that CMEPP can generate a significant impact on the development of Paralympic and parasport activities through four guiding pillars: Health, Education, High Performance, and Technology. These areas have strong potential …
The association between sedentary behavior, physical inactivity and high caloric intake favors the accumulation of fat in the central region, increasing the risk of developing non-communicable chronic diseases. In addition, this condition affects the neuro-immune axis, impacting macrophage ²-adrenergic signaling, and mitochondrial metabolism, favoring polarization toward a persistent infl…
(Only some records are available in English at this moment)
Sex hormones are known to interact with the immune system on multiple levels given that sex hormone receptors (SHRs) have been found in several types of immune cells including mononuclear cells, such as monocytes. Nonetheless, it is not clear how the level of physical fitness may control the inflammatory response in women at different stages of their reproductive life. In this sense, info…
A adolescência representa um período crítico para estabelecer hábitos de saúde ao longo da vida, como a rotina de exercícios físicos. O exercício durante o crescimento desempenha um papel importante em diferentes sistemas fisiológicos, incluindo o sistema imunológico. Períodos prolongados de inatividade física podem levar a uma diminuição na função das células imunológicas, prejudicando a…
During the period of the COVID-19 pandemic, studies have shown a high rate of sedentary behavior, physical inactivity, mood disorders and reduced sleep quality, in parallel with a reduction in physical exercise. The importance of physical exercise for the maintenance of physical and mental health is well established in the literature, exerting positive effects in the treatment of cognitiv…
(Only some records are available in English at this moment)
Cancer imposes a severe public health and economic burden, with hematologic malignancies often requiring high-cost procedures such as allogeneic hematopoietic cell transplantation (allo-HCT) and donor lymphocyte infusion (DLI). Mitochondrial function plays a pivotal role in post-transplant immunity, influencing both antitumor effects and graft-versus-host disease risk. Exercise, a low-cos…
The association between sedentary behavior, physical inactivity and high caloric intake favors the accumulation of fat in the central region, increasing the risk of developing non-communicable chronic diseases. In addition, this condition affects the neuro-immune axis, impacting macrophage mitochondrial metabolism, favoring polarization toward a persistent inflammatory state. On the other…
Ageing is associated with progressive alterations in cellular metabolism and immune system regulation, contributing to chronic low-grade inflammation and increased susceptibility to age-related diseases. Evidence indicates that regular physical exercise throughout life can attenuate these processes, promoting improved immune function and greater metabolic resilience. In this context, extr…
The major aim of this study is to explore the mechanisms involved in the metabolic programming of CD4+ T cells dependent on regular exercise as a potential determinant for better immune function. The questions that we propose to address in this proposal are:1) Does metabolic preferences of CD4+T cells change over time (from adolescence to old age) and explain their functionality changes? …
The major aim of this study is to investigate the immunometabolic mechanisms of the antitumoral effects of NK cells in individuals engaged in lifelong exercise. The question that we propose to address is this proposal is: Can regular physical exercise create a metabolic and immune environment that suppresses tumorigenesis? We hypothesized that exercise-induced delay in immunosenescence, s…
Derived from a myeloid lineage in the bone marrow, monocytes are blood cells of the immune system that in tissues differentiate into macrophages with an anti-inflammatory (M2) or pro-inflammatory (M1) state. The polarization of macrophages to the inflammatory state in metabolic disorder, or repair in tissue and systemic homeostatic situations, is well established in the literature, showin…
(Only some records are available in English at this moment)