Dr. Steiner did his undergraduate and graduate training at the University of Sao Paulo (Brazil), having obtained his PharmD in 1999 and his PhD in Physiology in 2002. He did his postdoctoral training at Joseph?s Hospital & Medical Center (Phoenix, AZ, USA) from 2002 to 2007. His first faculty appointment was as an Assistant Professor at the Albany College of Pharmacy & Health Sciences (Albany, NY, USA), where he stayed until 2012. Since then, Dr. Steiner has been a faculty member in Immunology at the Institute of Biomedical Sciences of the University of Sao Paulo, where he currently occupies an Associate Professor position. The Steiner laboratory studies the multilateral interactions among immune system and physiological systems in life-threatening infections (sepsis) and systemic inflammation. The overall goal is to identify the mechanisms by which these systems cooperate or compete with each other under different contexts. Many, but certainly not all, of the cooperative mechanisms rely on the central nervous system as an integrator of immune, physiological and environmental clues. Currently, Dr. Steiner?s research projects fall in one of three lines of investigation: (i) Tissue-specific functions of resident macrophages, their crosstalk, and their neuroendocrine modulation; (ii) Cost-benefit relationship of fever versus hypothermia in bacterial sepsis and fungal infections; (iii) Hemodynamics of septic shock. E-mail: asteiner@usp.br. (Source: Lattes Curriculum)
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By monitoring systemic hemodynamics with the highest temporal resolution in unanesthetized rats, in combination with ex-vivo assessment of vascular function, we found that early development of hypotension following injection of bacterial lipopolysaccharide (LPS) is brought about by a fall in vascular resistance when arterioles are still fully responsive to vasoactive agents. This approach…
Sepsis (systemic inflammation in the setting of infection) is a leading cause of mortality in Brazil and worldwide. A switch in thermal state from fever to hypothermia occurs in the most severe cases of sepsis, which has led to the perception that hypothermia reflects organ failure and is detrimental. We argue that this perception may be premature and incorrect, since there is evidence in…
Sepsis (systemic inflammation in the setting of infection) is a leading cause of mortality in Brazil and worldwide. A switch in thermal state from fever to hypothermia occurs in the most severe cases of Sepsis, which has led to the perception that hypothermia reflects organ failure and is detrimental. We argue that this perception may be premature and incorrect, since there is evidence in…
Septic shock is seen as a condition in which decreases in systemic vascular resistance (SVR) compromise tissue perfusion pressure. In this project, unexpected preliminary results have led us to question the applicability of this model to the most terminal phase of septic shock. We hypothesize that this terminal phase is associated with a switch in hemodynamic profile, with SVR transitioni…
Systemic inflammation is invariably associated with a thermoregulatory response: fever or hypothermia. The mechanisms of the selection between these responses are virtually unknown. We propose that the adipocyte-derived hormone, leptin, links the energy status of a subject to the selection of an appropriate thermoregulatory response during systemic inflammation. Conscious rats will be inj…
The inflammatory response to a widespread infection is an immune response mechanism capable of protecting the body against pathogen infections, but if unregulated, it can also lead to sepsis. The inflammatory reflex pathway has been described as capable of generating the necessary regulation for the acute inflammatory response.The increased predisposition to bacterial infections due to vi…
By monitoring systemic hemodynamics with the highest temporal resolution in unanesthetized rats, in combination with ex-vivo assessment of vascular function, we found that early development of hypotension following injection of bacterial lipopolysaccharide (LPS) is brought about by a fall in vascular resistance when arterioles are still fully responsive to vasoactive agents. This approach…
Inflammation is a protective response of the body, coordinated by cells of the immune system, which is extremely important in containing an infectious process and, therefore, must be precisely regulate, as it can cause collateral damage. For this regulation, the adjustments of the inflammatory process occur through the bidirectional interaction between the Central Nervous System (CNS) and…
(Only some records are available in English at this moment)
Previous results in our laboratory demonstrated a spleen-liver axis regulates TNF production in the bacterial lipopolysaccharide (LPS) induced systemic inflammation model in rats. Our proposal is that humoral signals released by spleen macrophages (which may include leukotriene B4) reach the liver via the bloodstream, where they interact with the liver's resident macrophages (Kupffer cell…
There is a two-way communication between the nervous and immune systems.Recent evidence has revealed that the splanchnic nerve, through its sympathetic fibers,suppresses by up to 80% the inflammatory response to a bacterial component, thelipopolysaccharide (LPS). Considering the intimate relationship between inflammation and immunity, this reflex is likely to have implications for infecti…
Cyclooxygenases (COX) are key enzymes in the biosynthesis of lipid mediators that play key roles in inflammation, especially the inducible isoform, called COX-2. The "constitutive" isoform, called COX-1, is seen asan enzyme of importance for "housekeeping" functions, with no role in inflammation.Recent evidence challenges this paradigm by revealing that COX-1 can also beimportant in infla…
(Only some records are available in English at this moment)
Resident macrophages are sentinel immune cells that sense microbes and the tissue microenvironment, being essential for host defense. They are highly heterogeneous, with each subpopulation playing tissue-specific roles. However, the cellular mechanisms underlying such heterogeneity are not understood, and neither are the mechanisms by which macrophages from distinct organs communicate wit…
As presented in the activity report, the results obtained so far not only question the prematurely accepted pro-inflammatory role of leptin, but, on the contrary, demonstrate that physiological concentrations of leptin exert anti-inflammatory effects. Our results further show that such anti-inflammatory effect does not result from a direct action of leptin on peripheral macrophages. Lepti…
| 3 / 3 | Ongoing grants |
| 2 / 2 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 21 / 14 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 32 / 25 | All research grants and scholarships |
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