CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC) (Institutional affiliation from the last research proposal) Birthplace: Inglaterra
bachelor's at Ciências Médicas Básicas e Bioquímica from University of London (1983), master's at Cristalografia from University of London (1984) and doctorate at Cristalografia from University of London (1989). Has experience in Byophysics, focusing on Molecular Biophysics, acting on the following subjects: proteínas, schistosoma mansoni, trypanosoma cruzi, transferrins and transferrina. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| The essence of molecules |
| La esencia de las moléculas |
| The essence of molecules |
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| News published in Agência FAPESP Newsletter about the researcher |
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| TITULO |
| Articles published in other media outlets ( ): |
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| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Septins are cytoskeletal GTP-binding proteins involved in key cellular events including cytokinesis, vesicle trafficking and exocytosis. In humans, different septins self associate in a specific manner to form hexameric or octameric heterocomplexes. These interact via their extremities to form filaments which are capable of assembling into higher order structures. It is known that ectopic…
Septins are cytoskeletal GTP-binding proteins involved in key cellular events including cytokinesis, vesicle trafficking and exocytosis. In humans, different septins self associate in a specific manner to form hexameric or octameric heterocomplexes. These interact via their extremities to form filaments which are capable of assembling into higher order structures. It is known that ectopic…
To perform their biological functions, proteins must fold into defined three-dimensional structures. These structures are highly conserved, such that ~92 million protein sequences are classifiable in only ~6,000 structures. In these scaffolds, residues that are essential for the chemical origin of protein function are placed in specific positions, thus being highly conserved between prote…
The Gryphon crystallization robot allows for screening conditions using small protein volumes. This equipment leads to a significant gain in productivity facilitating the crystallization of heretofore intractable samples. (AU)
(Only some records are available in English at this moment)
In recent years, plastics have become one of the products with the greatest accumulation in the environment, with their fragmentation representing one of the main sources of pollution. Polyethylene terephthalate (PET), a plastic widely used mainly in the manufacture of disposable bottles, has become a priority target for decomposition and pollution mitigation strategies. However, the meth…
Ascorbic acid is essential for health, especially due to its antioxidant action. For some animals, such as primates, plants are the main source of ascorbic acid due to the lack of one of the enzymes in the biosynthesis pathway. Thus, Myciaria dubia (Kunth) McVaugh, a native Amazonian plant, stands out as it contains 0.96 to 2.99 grams of ascorbic acid per 100 grams of pulp. The metabolic …
More than 50 years ago, septins were first described in Saccharomyces cerevisiae. Initially, studies showed that they formed a collar around the budding neck, which was important for the recruitment of proteins for cytokinesis. Today, it is known that septins are ubiquitous in fungi and animals, and may be involved in many important processes in the cell besides cytokinesis, such as phago…
The main role of the postdoctoral fellow will be to consolidate the leading position in septin crystallography that the group proposing the thematic project currently occupies. There are still questions concerning the structure/function relationship of septins that need clarification and where the determination of new crystallographic structures has much to contribute. Considering the exi…
In 2016, during the Zika outbreak in Brazil, an increase of 26 times in microcephaly cases was reported, shocking the country. In these cases, during infection, the virus mainly targets neuronal progenitor cells (NPCs), decreasing their proliferation that leads to cell death, which contributes to microcephaly. By identifying the isolated effect of viral proteins on these cells, Li et al. …
(Only some records are available in English at this moment)
Septins are crucial components of the eukaryotic cytoskeleton, involved in a wide range of cellular processes, including cytokinesis, membrane compartmentalization, and vesicle trafficking. To perform their functions, septins need to form heterofilaments, which subsequently assemble into higher-order structures such as rings, networks, and more. Classified into four groups, septin heterof…
Septins are membrane-associated GTP-binding proteins which are important in a wide range of physiologically essential processes such as cytokinesis, microtubule dynamics, formation of diffusion barriers and mechanotransduction. The importance of the coiled-coil domains in the formation and maintenance of septin complexes is still not fully understood. It has been almost 15 years since the…
Septins are GTP binding proteins considered to be a novel component of the cytoskeleton. These proteins interact with each other to form filamentous heterocomplexes and higher order structures which are important for cytokinesis, plasma membrane compartmentalization and a variety of other cellular processes. The oligomers themselves can vary in size and composition from species to species…
Septins are GTPases that interact with one another to form filaments and take part in several fundamental cellular processes such as cytokinesis and plasma membrane compartmentalization. Even though there exist a growing interest in this important cytoskeletal component, several aspects of septin polymerization, bundling and function remain unclear. In an attempt to shed light on these qu…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 15 / 12 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 46 / 23 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 72 / 46 | All research grants and scholarships |
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