CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Licenciatura Em Física from Universidade de São Paulo (1971), master's at Material and Metallurgical Engineering from Universidade de São Paulo (1977) and ph.d. at Physic from Universidade de São Paulo (1984). Has experience in Byophysics, focusing on Molecular Biophysics, acting on the following subjects: dna, equação poisson-boltzmann, actinomycin d, peptide and wasp venom. (Source: Lattes Curriculum)
The antimicrobial peptide Polybia-MP1 (MP1) extracted from the native wasp Polybia paulista, revealed to be inhibitor of cancer cell proliferation besides its potent antibacterial activity. It selectively recognized leukemic T-limphocytes but not the health ones, displaying thus a potential for pharmaceutical and medical applications. We gathered strong experimental evidences indicating t…
Studies of the correlations between structural features of lytic peptides, from the mastoparan family, and their lytic activity in model membrane and antimicrobial activity developed in our laboratory by different experimental approaches, have evidenced different mechanisms of action for the same peptide, depending on the peptide to lipid ratio. These studies have revealed that a group o…
(Only some records are available in English at this moment)
Polybia-MP1, extracted from the venom of a Brazilian wasp Polybia paulista, is highly active on the anionic lipid membrane surface displaying antimicrobial and anticancer activities. Our hypothesis is that changes that occur on the surface of apoptotic cell, as compressibility, elasticity, fluidity modulated by different lipid composition, are the key to a selectivity of Polybia-MP1 to th…
Studies of correlations between structural aspects of lytic peptides, mastoparanos the family, and their lytic activity in model membranes, and antimicrobial activities performed by different experimental approaches, showed different mechanism of action for the same peptide depending on the ratio peptide/lipid. These studies revealed that a number of mastoparanos extracted from native was…
Polybia-MP1 (or simply MP1) is a peptide that displays antimicrobial and anticancer activities. We gathered experimental evidences during the doctorate and post-doctorate projects (FAPESP grants #2012/08147-8, #2015/01508-3 and #2015/25620-7) suggesting that (1) a synergy between the anionic lipid phosphatidylserine and liquid ordered domains significantly influences the lytic activity of…
A growing number of studies have shown that some of the cationic antimicrobial peptides (AMPs) have a broad spectrum of cytotoxic activity against cancer cells. The antimicrobial tetradecapeptide Polybia-MP1, extracted from a native wasp, exhibits antitumor activity on prostate and bladder cancer cell cultures and high specificity to leukemic T-lymphocyte. Its inhibitory effect on cancer …
| 7 / 4 | Completed research grants |
| 6 / 2 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 15 / 8 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 13 |
| Citations | 160 |
| Cit./Article | 12.3 |
| Data from Web of Science | |
PUIA ZANIN, LUCIANA MORO; ALVARES, DAYANE DOS SANTOS; JULIANO, MARIA APARECIDA; PAZIN, WALLANCE MOREIRA; ITO, AMANDO SIUITI; RUGGIERO NETO, JOO. Interaction of a synthetic antimicrobial peptide with model membrane by fluorescence spectroscopy. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, v. 42, n. 11-12, p. 819-831, DEC 2013. Web of Science Citations: 10. (11/11640-5, 12/08147-8)
MORO ZANIN, LUCIANA PUIA; DE ARAUJO, ALEXANDRE SUMAN; JULIANO, MARIA APARECIDA; CASELLA, TIAGO; LELLES NOGUEIRA, MARA CORREA; RUGGIERO NETO, JOAO. Effects of N-terminus modifications on the conformation and permeation activities of the synthetic peptide L1A. Amino Acids, v. 48, n. 6, p. 1433-1444, JUN 2016. Web of Science Citations: 3. (10/18169-3, 11/11640-5)
ALVARES, DAYANE S.; RUGGIERO NETO, JOAO; AMBROGGIO, ERNESTO E.. Phosphatidylserine lipids and membrane order precisely regulate the activity of Polybia-MP1 peptide. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1859, n. 6, p. 1067-1074, JUN 2017. Web of Science Citations: 4. (15/01508-3, 12/08147-8, 11/11640-5, 15/25620-7, 11/51684-1, 15/25619-9)
MIASAKI, KENNETH M. F.; WILKE, NATALIA; RUGGIERO NETO, JOAO; ALVARES, DAYANE S.. N-terminal acetylation of a mastoparan-like peptide enhances PE/PG segregation in model membranes. Chemistry and Physics of Lipids, v. 232, OCT 2020. Web of Science Citations: 0. (15/25620-7, 15/25619-9)
ALVARES, DAYANE S.; WILKE, NATALIA; RUGGIERO NETO, JOAO. Effect of N-terminal acetylation on lytic activity and lipid-packing perturbation induced in model membranes by a mastoparan-like peptide. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1860, n. 3, p. 737-748, MAR 2018. Web of Science Citations: 2. (15/25619-9, 15/25620-7)
DOS SANTOS CABRERA, MARCIA P.; ALVARES, DAYANE S.; LEITE, NATALIA B.; DE SOUZA, BIBIANA MONSON; PALMA, MARIO S.; RISKE, KARIN A.; NETO, JOAO RUGGIERO. New Insight into the Mechanism of Action of Wasp Mastoparan Peptides: Lytic Activity and Clustering Observed with Giant Vesicles. Langmuir, v. 27, n. 17, p. 10805-10813, SEP 6 2011. Web of Science Citations: 34. (10/11823-0, 06/57122-7)
DE SOUZA‚ F.P.; NETO‚ A.A.; FOSSEY‚ M.A.; NETO‚ J.R.. The effect of changes in the bulk dielectric constant on the DNA torsional properties. Biopolymers, v. 87, n. 4, p. 244-248, 2007.
LEITE, NATALIA BUENO; DA COSTA, LAIANA CRISTINA; ALVARES, DAYANE DOS SANTOS; DOS SANTOS CABRERA, MARCIA PEREZ; DE SOUZA, BIBIANA MONSON; PALMA, MARIO SERGIO; RUGGIERO NETO, JOAO. The effect of acidic residues and amphipathicity on the lytic activities of mastoparan peptides studied by fluorescence and CD spectroscopy. Amino Acids, v. 40, n. 1, p. 91-100, JAN 2011. Web of Science Citations: 22.
DOS SANTOS CABRERA, MARCIA PEREZ; ARCISIO-MIRANDA, MANOEL; GORJAO, RENATA; LEITE, NATALIA BUENO; DE SOUZA, BIBIANA MONSON; CURI, RUI; PROCOPIO, JOAQUIM; RUGGIERO NETO, JOAO; PALMA, MARIO SERGIO. Influence of the Bilayer Composition on the Binding and Membrane Disrupting Effect of Polybia-MP1, an Antimicrobial Mastoparan Peptide with Leukemic T-Lymphocyte Cell Selectivity. BIOCHEMISTRY, v. 51, n. 24, p. 4898-4908, JUN 19 2012. Web of Science Citations: 18. (10/52077-9, 10/11823-0, 06/57122-7)
ALVARES, DAYANE S.; VIEGAS, TAISA G.; NETO, JOAO RUGGIERO. The effect of pH on the lytic activity of a synthetic mastoparan-like peptide in anionic model membranes. Chemistry and Physics of Lipids, v. 216, p. 54-64, NOV 2018. Web of Science Citations: 1. (15/25619-9, 15/25620-7)
ALVARES, DAYANE S.; WILKE, NATALIA; RUGGIERO NETO, JOAO; FANANI, MARIA LAURA. The insertion of Polybia-MP1 peptide into phospholipid monolayers is regulated by its anionic nature and phase state. Chemistry and Physics of Lipids, v. 207, n. A, p. 38-48, OCT 2017. Web of Science Citations: 8. (11/51684-1, 12/08147-8, 11/11640-5, 15/25619-9, 15/01508-3, 15/25620-7)
DIAS‚ B.; MARCIO‚ V.; ELY‚ F.; PALMA‚ M.S.; DE AZEVEDO‚ W.F.; BASSO‚ L.A.; SANTOS‚ D.S.. Chorismate synthase: an attractive target for drug development against orphan diseases. CURRENT DRUG TARGETS, v. 8, n. 3, p. 437-444, 2007. (01/07532-0)
RIBEIRO MARQUES‚ M.; HENRIQUE PEREIRA‚ J.; OLIVEIRA‚ J.S.; AUGUSTO BASSO‚ L.; FILGUEIRA DE AZEVEDO‚ W.; SANTIAGO SANTOS‚ D.; SERGIO PALMA‚ M.. The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials. CURRENT DRUG TARGETS, v. 8, n. 3, p. 445-457, 2007. (01/07532-0)
ALVARES, DAYANE S.; VIEGAS, TAISA G.; NETO, JOAO RUGGIERO. The effect of pH on the lytic activity of a synthetic mastoparan-like peptide in anionic model membranes. Chemistry and Physics of Lipids, v. 216, p. 54-64, NOV 2018. Web of Science Citations: 1. (15/25620-7, 15/25619-9)
DOS SANTOS CABRERA, MARCIA PEREZ; ARCISIO-MIRANDA, MANOEL; GORJAO, RENATA; LEITE, NATALIA BUENO; DE SOUZA, BIBIANA MONSON; CURI, RUI; PROCOPIO, JOAQUIM; RUGGIERO NETO, JOAO; PALMA, MARIO SERGIO. Influence of the Bilayer Composition on the Binding and Membrane Disrupting Effect of Polybia-MP1, an Antimicrobial Mastoparan Peptide with Leukemic T-Lymphocyte Cell Selectivity. BIOCHEMISTRY, v. 51, n. 24, p. 4898-4908, JUN 19 2012. Web of Science Citations: 18. (10/11823-0, 10/52077-9, 06/57122-7)
LEITE, NATALIA BUENO; DA COSTA, LAIANA CRISTINA; ALVARES, DAYANE DOS SANTOS; DOS SANTOS CABRERA, MARCIA PEREZ; DE SOUZA, BIBIANA MONSON; PALMA, MARIO SERGIO; RUGGIERO NETO, JOAO. The effect of acidic residues and amphipathicity on the lytic activities of mastoparan peptides studied by fluorescence and CD spectroscopy. Amino Acids, v. 40, n. 1, p. 91-100, JAN 2011. Web of Science Citations: 22.
(References retrieved automatically from State of São Paulo Research Institutions)
DIAS, Marcio Vinicius Bertacine. Estudo estrutural de proteínas alvo de Mycobacterium tuberculosis. 125 f. Tese (Doutorado) - Instituto de Biociências, Letras e Ciências Exatas. Universidade Estadual Paulista. São José do Rio Preto. (03/12472-2)
ALVARES, Dayane dos Santos. Estudo da formação de domínios em membranas modelos induzidos por peptídeos antimicrobianos e sua ação interfacial. 157 f. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências, Letras e Ciências Exatas. (12/08147-8)