João Ruggiero Neto

• Abstract

  The antimicrobial peptide Polybia-MP1 (MP1) extracted from the native wasp Polybia paulista, revealed to be inhibitor of cancer cell proliferation besides its potent antibacterial activity. It selectively recognized leukemic T-limphocytes but not the health ones, displaying thus a potential for pharmaceutical and medical applications. We gathered strong experimental evidences indicating t…

  Effect of aminophospholipids and of the pH on the interfacial activity of the anticancer peptide Polybia-MP1 and analogs in model membranes, AP.R

• Abstract

  Studies of the correlations between structural features of lytic peptides, from the mastoparan family, and their lytic activity in model membrane and antimicrobial activity developed in our laboratory by different experimental approaches, have evidenced different mechanisms of action for the same peptide, depending on the peptide to lipid ratio. These studies have revealed that a group o…

  Interaction of lytic peptides and model membranes: intefacial action and induction of lipid domains, AP.R
• Walter induced enthalpy - entropy compensation on drug intercalation to dna., AR.EXT

(Only some records are available in English at this moment)

• Abstract

  Polybia-MP1, extracted from the venom of a Brazilian wasp Polybia paulista, is highly active on the anionic lipid membrane surface displaying antimicrobial and anticancer activities. Our hypothesis is that changes that occur on the surface of apoptotic cell, as compressibility, elasticity, fluidity modulated by different lipid composition, are the key to a selectivity of Polybia-MP1 to th…

  Interaction membrane/peptide: mechanical and electrostatic properties in system with lipid domains, BP.PD

• Abstract

  Studies of correlations between structural aspects of lytic peptides, mastoparanos the family, and their lytic activity in model membranes, and antimicrobial activities performed by different experimental approaches, showed different mechanism of action for the same peptide depending on the ratio peptide/lipid. These studies revealed that a number of mastoparanos extracted from native was…

  Study of domains formation in model membranes induced by antimicrobial peptides and their action interfacial, BP.DR

• Abstract

  Polybia-MP1 (or simply MP1) is a peptide that displays antimicrobial and anticancer activities. We gathered experimental evidences during the doctorate and post-doctorate projects (FAPESP grants #2012/08147-8, #2015/01508-3 and #2015/25620-7) suggesting that (1) a synergy between the anionic lipid phosphatidylserine and liquid ordered domains significantly influences the lytic activity of…

  Regulation of the activity of antimicrobial peptides by the mechanical properties of the host membrane, BE.EP.PD

• Abstract

  A growing number of studies have shown that some of the cationic antimicrobial peptides (AMPs) have a broad spectrum of cytotoxic activity against cancer cells. The antimicrobial tetradecapeptide Polybia-MP1, extracted from a native wasp, exhibits antitumor activity on prostate and bladder cancer cell cultures and high specificity to leukemic T-lymphocyte. Its inhibitory effect on cancer …

  Interaction of the antimicrobial and antitumor peptide, Polybia-MP1, with lipid-domains, BE.EP.DR