CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas (FCM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Medicina from Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo (1981) and ph.d. at Phd Of Philosophy Em Farmacologia from University of London (1986). Has experience in Pharmacology, focusing on Clinical Farmacology, acting on the following subjects: nitric oxide, bioavailability, bradykinin, edrf and endothelin-1. (Source: Lattes Curriculum)
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6-Nitrodopamine (6-ND) is a recently discovered endogenous catecholamine released from vascular tissues, the heart endothelium, and seminal vesicle epithelium. It is the predominant catecholamine released from isolated vascular tissues in both mammals and reptiles, and its release is significantly reduced by the nitric oxide (NO) synthase inhibitor N ¿ -nitro-L-arginine methyl ester (L-NA…
Andreas Papapetropoulos is a full professor of Pharmacology at the Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens. Professor Papapetropoulos is a word expert on the pharmacology of H2S. Hydrogen sulfide has emerged as an endogenous regulator of a broad range of physiological functions; it belongs to the class of molecules known as gasotransmitters, which…
Nitric oxide (NO), is commonly produced within the endothelial cells and is argued to possess potent vasodilatory effects. NO may induce nitration of catecholamine neurotransmitters, resulting in corresponding 6-nitroderivatives. Recently, the 6-nitroderivatives were demonstrated to affect vascular tone and cardiac chronotropy and inotropy. Additionally, a new family of catecholamines, al…
(Only some records are available in English at this moment)
Professor Tobias Wang is currently one of the leading researchers in the field of comparative physiology, and his research encompasses various regulatory and adaptive issues in vertebrates. His collaboration with my research group at UNICAMP aims to expand the scope of our investigations incorporating evolutionary, adaptive, and integrative aspects. Additionally, it aims to broaden the sc…
The endothelium is an organ capable of regulating vascular tone through the release of endothelium-derived relaxing factors (nitric oxide and prostacyclin - PGI2) and endothelium-derived contracting factors (endothelin - ET1 and prostanoid - PGH2). In addition, the current physiological concept poses that such regulation can also occur through the release of exclusively neural-derived cat…
Reptiles are the first amniotes to develop an intromitent penis, however until now the mechanisms involved in the electrical field stimulation-induced contraction on corpora cavernosa isolated from Crotalus durissus terrificus were not investigated. Crotalus and rabbit corpora cavernosa were mounted in 10 mL organ baths for isometric tension recording. Electrical field stimulation (EFS)-i…
(Only some records are available in English at this moment)
Studies on isolated tissues from mammals and reptiles have reported the presence and/or vasoactive function of endothelium-derived catecholamines, such as dopamine, noradrenaline and adrenaline, as well as recent findings (6-nitrodopamine - 6-ND, 6-cyanodopamine, 6-bromodopamine, 6-nitrodopa, and 6-nitroadrenaline). The presence of catecholamines in ectotherms and endotherms vasculature s…
Dopamine (DA), noradrenaline, and adrenaline are known for their sympathomimetic roles. In the heart, the right isolated rat atrium has greater expression of beta-1 adrenoceptors compared to the left atrium of the same animal, making it a source of chronotropism study. 6-nitrodopamine (6-ND) emerges as the main new catecholamine responsible for the positive chronotropic and inotropic effe…
A new set of endogenous mediators known as novel catecholamines has recently been described. The novel catecholamines include the group of 6-nitrocatecholamines (6-NCT) and derivatives with a cyanide group, such as 6-cyanodopamine (6-CD), constituting a broad family of catecholamine-derived mediators.The synthesis of 6-NCT occurs through the nitration of catecholamines by nitric oxide. 6-…
(Only some records are available in English at this moment)
In a directly isolated rat atrium, 6-nitrodopamine has a potent positive chronotropic effect, being more potent than the classic catecholamines norepinephrine, adrenaline and dopamine. Another interesting feature of 6-nitrodopamine (6-ND) is its ability to synergize with classical catecholamines. In anesthetized rats, 6-ND has a potent positive chronotropic effect, however this positive c…
Endothelial cells modulate vascular reactivity through the release of mediators such as nitric oxide and endothelin. The current dogma is that catecholamines modulate vascular tonus, cardiac chronotropism and inotropism through their release from adrenergic terminals, and with action on a and b adrenergic receptors. Using mass spectrometry, we identified basal release of endothelium-depen…
6-nitrocatecholamines are a class of nitrated catecholamine-derived molecules, which includes 6-nitrodopamine, 6-nitroadrenaline and 6-nitronadrenaline. Current evidence indicates that those molecules are endogenously synthesized and constitute important modulators of cell signaling in different tissues. Vas deferens is one of those tissues whose function is potentialy modulated by 6-nitr…
(Only some records are available in English at this moment)
6-nitrodopamine (6-ND) is a novel catecholamine with significant role as a cardiovascular mediator. In the hypertension model with N¿-nitro-L-arginine methyl ester (L-NAME), the chronic treatment with 6-ND prevented the hypertension and heart lesions. In addition, previous studies showed that its basal release is increased with hydrogen peroxide, superoxide dismutase, and decreased with c…
6-Nitrodopamine (6-ND) is a newly identified catecholamine released from vascular tissues. Its release is significantly reduced upon pharmacological blockade of NO synthesis with Nx-nitro-L-arginine methyl ester (L-NAME), and it functions as a vasodilator through dopamine D2-like receptor antagonism. Elevated blood pressure induced by L-NAME administration coincides with decreased heart r…
Endothelial cells modulate vascular reactivity through the release of mediators such as nitric oxide and endothelin. The current dogma is that catecholamines modulate vascular tone, chronotropism and cardiac inotropism through their release from adrenergic terminals, and through their action on ±- and beta-adrenergic receptors. We identified, through mass spectrometry, the basal release o…
The identification of the endothelium as a major source for catecholamines, and their role as main modulators of the cardiovascular system, has provoked a change in our understanding of the physiology and pharmacology of the circulation. 6-Nitrodopamine (6-ND) has been described as the most potent endogenous positive chronotropic and inotropic agent ever described, with different mechanis…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 35 / 23 | Completed research grants |
| 20 / 20 | Ongoing scholarships in Brazil |
| 76 / 27 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 142 / 81 | All research grants and scholarships |
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