Abstract
The bone marrow (BM) is composed by specific microenvironments: the osteoblastic niche, which is responsible for the maintenance of quiescent primitive hematopoietic stem cells, and vascular niche which maintains progenitor and stem cells proliferating and ready to begin the differentiation process. CXCL12 is an important chemo active factor produced by the BM cells; the action of this fa…