Bachelor's degree in Biological Sciences Medical Modality (Escola Paulista de Medicina, EPM, 1979), Master's (1983), and Ph. and at the Center for Vaccine Development (Baltimore, USA) (1986). She was a Postgraduate Adjunct Coordinator at the Dean of Postgraduate Studies and Research at the Federal University of São Paulo (UNIFESP) (03/2013-04/2017). She was Head of the Discipline of Microbiology at EPM, UNIFESP (2001-2003 and 2017-2022) and a member of the Graduate Teaching Commission of the Graduate Program in Microbiology and Immunology at UNIFESP (2001-2006 and 2017-current ). She is a Full Professor at UNIFESP, member and vice-coordinator of the Commission for Evaluation of Committee for Admission to the Teaching Career at EPM, member of the Commission for Accreditation and Re-accreditation of the Chamber of Graduate Studies and Research at EPM, UNIFESP (2014-current ). She is a Review Editor for the Frontiers in Cellular in Infection Microbiology Journal. She is a reviewer for several national and international journals. Member of the CNPq Advisory Committee on Microbiology and Parasitology (07/2022 to 06/2025) and coordinator of the Graduate Program in Microbiology and Immunology (EPM, UNIFESP) (06/2023-current). She has experience in the field of Microbiology (bacteriology), with emphasis on genetic diversity, bacterial pathogenicity, and epidemiology, working mainly on the following topics: adherence, invasion, diarrhea, mucus, mucinases, urinary tract infections, enteropathogenic Escherichia coli, enteroaggregative E. coli, uropathogenic E. coli, hybrid strains of E. coli and Escherichia albertii. (Source: Lattes Curriculum)
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Classically, pathogenic strains of Escherichia coli were thought to cause intestinal infections (II) or extraintestinal infections (IEI). However, several recent reports have demonstrated the occurrence of E. coli strains causing II and IEI in the same patient. Typical enteroaggregative E. coli (EAEC), one of the intestinal pathogenic E. coli pathotypes, is characterized by harboring a v…
Escherichia coli are characterized by harboring both commensal and / or symbiotic strains, as well as strains that are pathogenic to the intestinal and extraintestinal sites of humans and warm-blooded animals. This plurality of behavior is due, on the one hand, to the fact that most of its virulence determinants are encoded in mobile genetic elements and, on the other hand, the extreme pe…
Some adapted clones of Escherichia coli carry genes that encode properties that allow them to colonize different host sites, favoring the establishment of intestinal or extraintestinal infections. Intestinal infections are caused by different diarrheogenic E. coli (DEC) pathotypes, while the extraintestinal infections are caused by strains of extraintestinal pathogenic E. coli (ExPEC). Ex…
Enteropathogenic Escherichia coli (EPEC) produce characteristic intestinal lesions (attaching/effacing lesions, A/E), being identified by the production of the localized adherence (LA+) pattern in HeLa cells. LA+ EPEC strains of the O119:H6 serotype constituted, for many decades, one of the most frequent childhood diarrheal agents in our environment. Curiously, we have identified O119:H6 …
(Only some records are available in English at this moment)
Infection of the intestinal epithelium by certain enteropathogens results in a modification in the expression of genes encoding pro-inflammatory cytokines and the production of mucins. Our group demonstrated that some strains of atypical enteropathogenic Escherichia coli (aEPEC) significantly increase mucus production when inoculated into ligated rabbit ileal loops in vivo. In the same st…
Escherichia coli is a globally distributed bacterium that colonizes the gut. E. coli strains can be divided into three groups: commensals, which are harmless to the host; diarrheagenic (diarrheagenic E. coli-DEC), which cause intestinal diseases; and those which cause extraintestinal infections (extraintestinal pathogenic E. coli-ExPEC). ExPEC strains are classified according to the site …
Some Escherichia coli strains present virulence factors that contribute to colonization, invasion and, consequently, the establishment of disease in different parts of the human body. E. coli strains capable of causing intestinal infections are called diarrheagenic E. coli (DEC) while those that cause extraintestinal infections are named extraintestinal pathogenic E. coli (ExPEC). The lat…
Escherichia coli is a gram-negative bacillus that can be classified into commensal strains and disease-causing strains. Diarrheogenic E. coli (DEC) are classified in five distinct pathotypes. One of these pathotypes, denominated enteropathogenic E. coli (EPEC), has two subdivisions, which are based on the presence (typical EPEC) or absence (atypical EPEC) of the EAF (EPEC adherence factor…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 21 / 11 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 21 / 9 | Completed scholarships in Brazil |
| 47 / 25 | All research grants and scholarships |
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