Luiz Carlos Dias
CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Química from Universidade Federal de Santa Catarina (1988) and doctorate at Chemistry from Universidade Estadual de Campinas (1993). He is currently full professor at Universidade Estadual de Campinas. Has experience in Chemistry, focusing on Organic Synthesis, acting on the following subjects: alilestanana quiral, alilsilano quiral, antitumor agents, natural product and condensacao aldolica. (Source: Lattes Curriculum)
- FAPESP/MMV/DNDi/UNICAMP/USP Consortium to discover new drugs for the treatment of tropical parasitic diseases, AP.PITE
Abstract
We propose to establish a FAPESP/MMV/DNDi/UNICAMP/USP consortium with the ultimate goal to discover novel drug candidates for clinical development. To this end, the consortium will place high priority on selecting team members from the state of Sao Paulo with a proven track record of high quality research. This group will work in collaboration with expert scientists from the Drugs for N...
- CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID
Abstract
The Center for Innovation in Biodiversity and Drug Discovery (CIBFar) is a joint initiative resulting from existing collaborative research projects, including the Physics Institute of São Carlos (IFSC) and the School of Pharmaceutical Sciences of Ribeirão Preto at the University of São Paulo (USP), the Institute of Chemistry at the State University of São Paulo (UNESP), the Institute of...
- New approaches toward sustainable catalysis in the synthesis of bioactive small molecules, AP.R
Abstract
In this proposal, the principal investigators will seek to develop new catalysts and strategies for the stereocontrolled preparation of small molecule building blocks. The main areas of investigation align with the strengths of the Pls and the goals articulated in this request for proposals. The creation of novel and selective methods for carbon-carbon and carbon-heteroatom bond constru...
- Journal of the Brazilian Chemical Society, PUB.PER
Abstract
Finantial proposal for the Journal of the Brazilian Chemical Society. (AU)
- Total synthesis of bioactive compounds: biological tests and design of new analogs, AP.R
Abstract
In this work we intend to investigate short and efficient synthetic routes that allow the total synthesis of marinisporolide A, natrangins A and B, tautomycetin, the antiasthmatic agent IMC-977 (LDP-977) and analogues of isomigrastatin and migrastatin. We intend to investigate synthetic alternatives that provide larger amounts of material for further biological studies, particularly ass...
(Only some records are available in English at this moment)
- Optimization of lead compounds for treatment of tropical parasitic diseases in collaboration with the Drugs for Neglected Diseases Initiative (DNDi), BP.DR
Abstract
The objective of the project is to continue the search for pharmacological innovations for the treatment of neglected diseases, especially CD and Leishmaniasis, through the synthesis of new analogues of target molecules sent by DNDi, as starting points. It is expected that the synthesized compounds will be able to progress in the drug development chain, reaching a suitable profile for a...
- Compounds synthesis for the treatment of Chagas Disease at RIDCs/FAPESP/DNDi, BP.PD
Abstract
The approach of this proposal is to use drug discovery leads from DNDi as starting points to deliver clinical candidates meeting the target product profiles (TPPs) for Chagas disease and visceral leishmaniasis (VL). The goal of this project is to deliver an optimised lead compound ready for preclinical and subsequently clinical development for the treatment of Chagas disease and/or visc...
- Synthesis of marine compounds ieodomycines A-D, comosusols A-D, comosone a and analogues: structure /activity relationships, BP.PD
Abstract
The synthesis of marine natural products has been a challenge to organic chemists, since these compounds may have highly complex structures. Some marine natural products have cytotoxic activity against cancer cells, bacterial and fungal. The ieodomycins A-D have been isolated from marine bacteria cultures and exhibit antimicrobial activity. Others marine compounds biologically active a...
- Total synthesis of marinisporolide a, BP.DR
(Only some records are available in English at this moment)
- Synthesis of anhydride fragment from tautomycetin, BE.EP.DR
Abstract
Tautomycetin (TTN) is natural polyketide isolated in 1989 from Streptomyces griseochromogenes. TTN is more seletive inhibitor of PP1 (serine/threonine phosphatase) known until now and it is a potent protein tyrosine phosphatase-2 (SHP2) inhibitor. The phosphatases protein have been investigated as a new strategy for cancer therapy. This project aim to develop a convergent synthetic rout...
| 2 / 2 | Ongoing research grants |
| 19 / 11 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 56 / 12 | Completed scholarships in Brazil |
| 2 / 1 | Completed scholarships abroad |
| 80 / 27 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 13 |
| Citations | 121 |
| Cit./Article | 9.3 |
| Data from Web of Science | |
MARILIA VALLI; WANESSA ALTEI; RICARDO N. DOS SANTOS; EMILIO C. DE LUCCA JR.; MARCO A. DESSOY; RENAN M. PIOLI; FERNANDO COTINGUIBA; XAVIER CACHET; SYLVIE MICHEL; MAYSA FURLAN; et al. Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration. Journal of the Brazilian Chemical Society, v. 28, n. 3, p. 475-484, Mar. 2017. (03/02176-7, 13/07600-3, 10/17329-7, 10/06741-4)
DIAS, LUIZ C.; DE LUCCA, JR., EMILIO C.. Total Synthesis of the Oxopolyene Macrolide (-)-Marinisporolide C. ORGANIC LETTERS, v. 17, n. 24, p. 6278-6281, DEC 18 2015. Web of Science Citations: 8. (12/02230-0, 11/06721-6, 13/07600-3)
ROSSINI, ALLAN F. C.; DIAS, LUIZ C.. Synthesis of the C(7)-C(20) Fragment of Spirotoamides A, B and C. Journal of the Brazilian Chemical Society, v. 30, n. 8, p. 1567-1578, AUG 2019. Web of Science Citations: 0. (15/50655-9)
DIAS, LUIZ C.; DE LUCCA, EMILIO C.. Total Synthesis of (-)-Marinisporolide C. Journal of Organic Chemistry, v. 82, n. 6, p. 3019-3045, MAR 17 2017. Web of Science Citations: 11. (12/02230-0, 11/06721-6, 13/07600-3)
DIAS, L. C.; KUROISHI, P. K.; DE LUCCA, JR., E. C.. The total synthesis of (-)-cryptocaryol A. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 13, n. 12, p. 3575-3584, 2015. Web of Science Citations: 12. (12/02230-0, 13/07600-3)
ZHOU, YONGJUN; PREDIGER, PATRICIA; DIAS, LUIZ CARLOS; MURPHY, ANNABEL C.; LEADLAY, PETER F.. Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 54, n. 17, p. 5232-5235, APR 20 2015. Web of Science Citations: 14. (12/02230-0, 12/04616-3)
MARTINEZ, PABLO D. G.; KRAKE, SUSANN H.; POGGI, MAITIA L.; CAMPBELL, SIMON F.; WILLIS, PAUL A.; DIAS, LUIZ C.. 2,3,8-Trisubstituted Quinolines with Antimalarial Activity. Anais da Academia Brasileira de Ciências, v. 90, n. 2, p. 1215-1231, 2018. Web of Science Citations: 1. (13/07600-3, 15/50655-9)
DIAS, LUIZ C.; VIEIRA, ADRIANO S.; BARREIRO, ELIEZER J.. The total synthesis of calcium atorvastatin. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 14, n. 7, p. 2291-2296, 2016. Web of Science Citations: 13. (12/02230-0)
SUPPO, JEAN-SIMON; DE SANT'ANA, DANILO PEREIRA; DIAS, LUIZ CARLOS; DE FIGUEIREDO, RENATA MARCIA; CAMPAGNE, JEAN-MARC. Efficient and Practical Procedure for the Esterification of the Free alpha-Carboxylic Acid of Amino Acid Residues with beta-(Trimethylsilyl)ethoxymethyl Chloride and Triisopropylsilyl Chloride. SYNTHESIS-STUTTGART, v. 46, n. 22, p. 3075-3084, NOV 2014. Web of Science Citations: 0. (12/11220-9)
FERREIRA, MARCO A. B.; DIAS, LUIZ C.; LEONARCZYK, IVES A.; POLO, ELLEN C.; DE LUCCA, JR., EMILIO C.. Exploring the Aldol Reaction in the Synthesis of Bioactive Compounds. CURRENT ORGANIC SYNTHESIS, v. 12, n. 5, p. 547-564, 2015. Web of Science Citations: 6. (12/02230-0, 11/06721-6, 13/02311-3, 11/06722-2)
FERREIRA, RAFAELA S.; DESSOY, MARCO A.; PAULI, IVANI; SOUZA, MARIANA L.; KROGH, RENATA; SALES, ANA I. L.; OLIVA, GLAUCIUS; DIAS, LUIZ C.; ANDRICOPULO, ADRIANO D.. Synthesis, Biological Evaluation, and Structure-Activity Relationships of Potent Noncovalent and Nonpeptidic Cruzain Inhibitors as Anti-Trypanosoma cruzi Agents. Journal of Medicinal Chemistry, v. 57, n. 6, p. 2380-2392, MAR 27 2014. Web of Science Citations: 24. (12/02230-0, 10/16778-2, 13/07600-3)
ZHOU, YONGJUN; MURPHY, ANNABEL C.; SAMBORSKYY, MARKIYAN; PREDIGER, PATRICIA; DIAS, LUIZ CARLOS; LEADLAY, PETER F.. Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin. CHEMISTRY & BIOLOGY, v. 22, n. 6, p. 745-754, JUN 18 2015. Web of Science Citations: 23. (12/02230-0, 12/04616-3)
DIAS, LUIZ C.; POLO, ELLEN C.. Nhatrangin A: Total Syntheses of the Proposed Structure and Six of Its Diastereoisomers. Journal of Organic Chemistry, v. 82, n. 8, p. 4072-4112, APR 21 2017. Web of Science Citations: 5. (12/02230-0, 13/07600-3, 11/06722-2)
AIMOLA, TULIO J.; LIMA, DIMAS J. P.; DIAS, LUIZ C.; TORMENA, CLAUDIO F.; FERREIRA, MARCO A. B.. H-1 chemical shift differences of Prelog-Djerassi lactone derivatives: DFT and NMR conformational studies. ORGANIC & BIOMOLECULAR CHEMISTRY, v. 13, n. 7, p. 2140-2145, 2015. Web of Science Citations: 4. (13/02311-3)