CV Lattes
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Institut Pasteur de São Paulo (IPSP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
He has a PhD in sciences in the area of microbiology at the University of São Paulo in 1989 and Postdoctorate in Virology at the CDC-Centers for Disease Control and Prevention, Atlanta, GA, USA (1990 to 1994) and member of the World Health Organization-who as representative of South America in the WHO Biosafety Advisory Group in the year 2004. Currently a Full Professor of virology and Chief of BSL3+ facility at the University of São Paulo-USP, Department of Microbiology of the Institute of Biomedical Sciences-ICB. Responsible for the Graduation on Biosafety of the Department of microbiology of the ICB since 2005. He has experience in the area of microbiology, with emphasis on virology, acting primarily in the following topics: clinical and molecular diagnosis, human and animal viruses, exantemátic viruses, respiratory viruses, wild viruses, emerging viruses, viral genetic diversity, biosafety level BSL 2 and BSL 3. (Source: Lattes Curriculum)
| Articles published in Pesquisa para Inovação FAPESP about the researcher: |
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The International Center Institut Pasteur of São Paulo (CIP IPSP) represents a pioneering, multidisciplinary partnership between researchers from leading institutions: the Institut Pasteur, together with its global network-the Pasteur Network-and the Universidade de São Paulo. These institutions joined forces to create the recently established Institut Pasteur de São Paulo, based at USP. …
Acute respiratory infections (ARI) are the most frequent infectious diseases in humans and respiratory viruses are the main etiological agents responsible for their occurrence. These agents are distributed worldwide and can cause a wide variety of clinical syndromes, such as upper and lower respiratory tract diseases (URTIs and LRTIs). ARIs are the main causes of morbidity and mortality w…
Infectious diseases are a significant burden on public health and economic stability of societiesall over the world. The threat posed by infectious diseases is further deepened by the continuedemergence of new, unrecognized, and old, re-emerging infectious diseases. This becameeven more prominent by the continuously increasing air traffic and the resulting possible globaldissemination of …
In December 2019, an outbreak of pneumonia caused by a new beta coronavirus was announced in Wuhan - China. Since then, the virus has spread to more than 195 countries and territories, and the number of reported cases of the disease has increased exponentially. Several agents for the treatment of the disease are being tested in clinical trials without controlled data on efficacy and safet…
The present grant application for a thematic research project has the main goal to offer financial support to different studies related to the Zika Vírus (ZIKV), presently under development at the Virology (LV) and Vaccine Research Laboratory (LDV) at the University of São Paulo (USP). The work is centered in four main themes: I) generation and application of ZIKV recombinant proteins aim…
The present invention describes the identification, production and testing of a recombinant ZIKV antigen which allows the development of specific serological tests for those infected with the virus. Unlike tests available on the market, the present antigen detected specifically antibodies produced in ZIKV-infected patients even from people which were infected previously by other flaviviru…
(Only some records are available in English at this moment)
O Brasil é um dos países fortemente afetados por doenças parasitárias causadas por patógenos virais. Essas infecções afetam gravemente a saúde pública e o bem-estar em grande parte do mundo tropical. As terapias medicamentosas existentes baseiam-se em substâncias ativas antigas e, muitas vezes, altamente tóxicas, e os relatos sobre o desenvolvimento de resistência por parte dos patógenos …
O projeto visa determinar pelo me¿todo de sequenciamento geno¿mico a circulac¿a¿o de variantes de SARS-COV o -2 , influenza vi¿rus A e vi¿rus sincicial respirato¿rio (VSR-A e VSR-B) isolados de crianc¿as hospitalizadas na cidade de Sa¿o Paulo caracterizando por meio de te¿cnicas de filogene¿tica o potencial pande¿mico de cada um desses agentes bem como avaliar a variabilidade gene¿tica do…
O projeto visa o diagno¿stico utilizando o me¿todo de RT-PCR TaqMan® Multiplex (Reverse Transcription Polymerase Chain Reaction) que sera¿ utilizado para detecc¿a¿o de SARS-COV-2 e mais 15 vi¿rus respirato¿rios: influenza vi¿rus A e B (Inf A e Inf B); coronavi¿rus sazonais (CoV- NL63, CoV-229E, CoV-HKU1 e CoV-OC43); enterovi¿rus (EV); parainfluenza vi¿rus (PIV-1, PIV-2, PIV-3 e PIV-4); me…
(Only some records are available in English at this moment)
Acute respiratory infections (ARIs) are the most frequent infectious diseases in humans and most respiratory infections observed in medical practice around the world are of viral etiology. Despite the vast number of viral agents involved in respiratory infections and its clinical importance, the Influenza virus (Flu) is one of the few that has a known and acceptable treatment. Today, in a…
Brazil is one of the countries strongly haunted by parasitic diseases caused by viralpathogens. These infections severely affect public health and welfare in a wide part ofthe tropical world. Existing drug therapies are based on old and often very toxic activesubstances and reports on developing resistance of pathogens are increasing. Thesearch for new chemical entities with anti-pathogen…
Measles is a highly contagious exanthematic disease (R0 18) caused by the Measles morbillivirus (MeV) virus, requiring a vaccination coverage of 95%, despite being preventable by vaccination since 1963, it still remains an important cause of mortality, causing outbreaks especially when vaccination coverage in populations decreases. The vaccine is also composed of the attenuated virus of t…
(Only some records are available in English at this moment)
Emerging viral hemorrhagic fevers, such as Ebola virus (EBOV) and Marburg virus (MARV), represent a major global threat due to their high fatality rates and potential for rapid outbreaks. These zoonotic viruses, mainly transmitted through direct contact with body fluids, cause severe disease with mortality exceeding 80% in some cases. EBOV has already caused large epidemics, such as the 2…
Brazil has the richest biodiversity of New World primate (NWP) in the Americas, many are endemic and nearly half (48%) with some degree of threat on the IUCN red list. Considering the One Health and the Anthropocene Age, one of the most worrying consequences is the Emergence and/or Reemergence of Infectious Diseases (EDIs and ReDIs). Thus, the metropolitan area of São Paulo is a clear exa…
Mayaro virus (MAYV) of the genus Alphavirus is a mosquito-transmitted emerging virus that causes an acute febrile illness similar to that produced by chikungunya virus (CHIKV), an evolutionary relative in the Semliki Forest virus complex of alphaviruses. MAYV emergence is typically sporadic, but recent isolations and outbreaks, and an increase in its known distribution, indicate that the …
The project will involve the use of several molecular biological methods and bioinformatic tools to study HIV. In Aim #1, long read sequencing methods using nanopore technology will be developed to study different splicing isoforms expressed from a novel HIV vector. Aim #2 will serve to identify host cell genes involved in nuclear retention of HIV mRNAs, as well as host genes that positiv…
(Only some records are available in English at this moment)