CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor at University of Campinas (UNICAMP). Graduation at Ciencias Biologicas from Universidade de São Paulo (1982), master's at Physiology from Universidade de São Paulo (1985) and doctorate at Physiology from Universidade de São Paulo (1994). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: cancer, carcinossarcoma de walker 256, crescimento e desenvolvimento, metabolismo proteico and gravidez. (Source: Lattes Curriculum)
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The main objective of our laboratory is to elucidate the metabolic and molecular effects of the development of cancer-induced cachexia. Cachexia, imposed by cancer, is considered one of the main problems in treating solid tumours, particularly of the pancreas, stomach, lung and colon; there is an intense wasting of host tissues, especially skeletal muscle. On the other hand, in these pati…
The acquisition of Multi-User Equipment (EMU) is an unquestionable gain for the advancement of science, providing researchers with access to cutting-edge technologies for the development of their projects in different areas of scientific research. In many cases, it is challenging for a researcher to secure resources for the acquisition of permanent materials, especially those related to h…
In our previous works related to cancer and Cachexia the main objectives are to elucidate the metabolic and molecular changes occurred during the development of the cancer cachectic state. Cachexia imposed by cancer, is considered a major problem in the treatment of solid tumors, especially pancreatic, stomach, lung and colon since these patients by intensive mobilization of substrates of…
Background: Cachexia is one of the most important causes of many cancer-related deaths. Cancer-cachexia is a complex metabolic syndrome characterised by involuntary weight loss, mostly due to the skeletal muscle tissue wasting. Leucine supplementation has been used to minimise muscle tissue depletion due to its ability to stimulate protein synthesis pathways and inhibit protein degradatio…
In our laboratory, we have as main objective the elucidation of metabolic and molecular effects of the cachectic state induced by tumour growth. Cancer-cachexia is considered a major problem in the treatment of solid tumours, especially pancreatic, stomach, lung and colon cancer, since these patients have intensive mobilization of host tissues, preferably depleting the skeletal muscle pro…
(Only some records are available in English at this moment)
Cancer-related to pregnancy is becoming more prevalent due to demographic changes such as advanced maternal age. Cachexia, characterized by muscle mass loss, is common in patients with advanced cancer, with cardiac cachexia being one of the most severe forms, associated with heart failure and significant mortality. Nutrition plays a crucial role in cancer treatment, and leucine has been s…
Cancer and pregnancy, individually, already cause significant changes in the offspring. However, in association, they cause hormonal and metabolic alterations that can potentially enhance the adverse effects on the mother and fetus. Recent studies suggest that changes in the gut microbiota can influence cancer and that leucine, a branched-chain amino acid, may positively affect the modula…
Cancer cachexia is a systemic multifactorial syndrome that alters several metabolic pathways and is mainly characterized by intense protein depletion from skeletal muscle. Depending on the progression of the disease, up to 80% of patients are affected by this syndrome, which is responsible for around 30% of all cancer-related deaths. More studies are needed to identify new strategies for …
(Only some records are available in English at this moment)
Breast cancer is the most prevalent type of cancer during pregnancy. In such cases, neoadjuvant chemotherapy treatment is frequently used to halt tumour progression. This treatment involves the administration of doxorubicin and cyclophosphamide. Although these drugs are effective in treating cancer, they can lead to serious cardiotoxic side effects, which limit treatment and significantly…
Problem statement: The incidence of cancer during pregnancy is increasing significantly due to several factors, such as advanced maternal age, cancer treatment, and preservation of fertility. This condition represents a major therapeutic challenge, as maternal and fetal/neonatal health must be taken into consideration. Placental dysfunctions resulting from cancer associated with pregnancy…
(Only some records are available in English at this moment)
Treating cancer during pregnancy poses a clinical conundrum of optimizing maternal health outcomes while safeguarding fetal well-being. The placenta provides a barrier between mother and fetus, and was shown to be affected by chemotherapeutic agents. However, how chemotherapy affects placental trophoblast development and functioning is largely unknown and cannot be readily investigated du…
Cancer cachexia is a complex, systemic, multifactorial syndrome that causes several metabolic alterations, affecting multiple organs, including the heart. Cardiac failures in patients with cancer cachexia have been widely reported, representing a severe problem limiting patient survival, but often underestimated and insufficiently studied. Cancer and heart diseases have been associated wi…
Most ovarian cancers are diagnosed late and have a poor prognosis that hasn't changed significantly over the last 30 years. Screening for ovarian cancer does not appear to reduce mortality therefore, the best chance to reduce mortality from ovarian cancer is prevention and identifying women at high risk. Epidemiology studies have confirmed that 5-10 years of oral contraceptive (OC) use re…
Cachexia is a multi-factorial syndrome that affects up to 80% of cancer patients and is significantly related to decrement of quality of life and cancer deaths. Skeletal muscle wasting is the main consequence of cachexia and largely contributes to involuntary weight loss. This skeletal muscle wasting is a result of an increase in protein breakdown and decrease in protein synthesis. Protei…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 22 / 16 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 42 / 32 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 76 / 60 | All research grants and scholarships |
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