Fernando Batista da Costa

• Abstract

  Female hop inflorescences (Humulus lupulus L.) have glandular trichomes that secrete a variety of secondary metabolites that are being used in sedative and cosmetic products, such as phytoestrogens and food supplements. However, most of the commercialization of hops is used in the brewing industry to aromatize and produce bitterness in beer due to the presence of bitter acids and volatile…

  Acclimation of Humulus lupulus in Brazil: development, physiology and metabolomics, AP.R

• Abstract

  The proposed project explores a botanical, Harpagophytum procumbens subsp. procumbens (Burch.) DC. Ex Meisn, family Pedaliaceae (Devil's Claw; Garra do Diabo) for which there is evidence of benefit to human health, namely its use in management of inflammatory arthritis, lower back pain and other musculoskeletal conditions. H. procumbens is one of the most frequently used herbal products f…

  Identification of secondary metabolites in Harpagophytum procumbens extracts that inhibit cyclooxygenases 1/2 and 5 - lipoxygenase expression and/or activities, AP.R SPRINT

• Abstract

  With the fast development of analytical techniques, especially chromatography and spectrometry, the time required for separation, isolation and identification of compounds from natural origin has decreased. Thus, the discovery process of novel biologically active compounds from natural resources has been facilitated, even more when this process is associated with in silico methods, for ex…

  Metabolomics, enzymatic targets and in silico tools in the search of bioactive compounds from plants, AP.R

(Only some records are available in English at this moment)

• Abstract

  Humulus lupulus L., also known as hop, is a plant that belongs to the Cannabaceae family and is known throughout the world as a raw material in the brewing industry, as well as its role in the pharmaceutical, nutritional, food and cosmetics industries. Hop female inflorescences form the hop cones, where the lupulin glands are developed, being responsible for the biosynthesis and storage o…

  Extraction and analysis of essential oil from Humulus lupulus L. cultivars (hops, Cannabaceae), BP.IC
• Acclimation of Humulus lupulus in Brazil: development, physiology and metabolomics, BP.TT

• Abstract

  The northern region of the tropical Andes in South America was subjected to a series of climate fluctuations as a consequence of the recurrent periods of glaciations and inter-glaciations that occurred in the late Pliocene and early Pleistocene, two to five million years ago. This led to the development of a new ecosystem called páramo, which combines the isothermal climatic conditions of…

  Metabolomics and evolution of chemical characters in the subtribe Espeletiinae (Asteraceae), BP.DR

(Only some records are available in English at this moment)

• Abstract

  Smallanthus sonchifolius ("yacón") along with the genus Espeletia (Asteraceae, Millerieae) constitute closely related plant groups native to the South American Andes. These species display not only a remarkable genetic similarity, but also a uniform secondary metabolite chemistry, producing the same structural subtype of sesquiterpene lactones (STLs). This class of secondary metabolites p…

  Metabolic fingerprinting and biosynthesis of sesquiterpene lactones in Smallanthus sonchifolius and Espeletia (Asteraceae): a metabolomic and transcriptomic approach, BE.EP.DR

• Abstract

  The application of informatics methods to solve chemical problems is called chemoinformatics. A large variety of chemoinformatic tools have been developed in the last years, covering from structural representation to data analysis methods. Drug discovery can be based on screening chemical compounds, regarding their physicochemical properties, applying chemoinformatic tools. Quantitative S…

  Chemoinformatic tools applied for the screening of inhibitors of the enzyme DHODH from Leishmania major, BE.EP.DR

• Abstract

  The properties of a chemical substance depend on both its structural characteristics as wellas the conditions that involve it. Quantitative Structure-Retention Relationship (QSRR)studies with the goal of understanding the behavior of natural compounds in different chromatographic conditions are proposed in this study. For this purpose, the use of analytical tools and strategies of chemome…

  Use of chemoinformatic tools to evaluate the behavior of retention times of natural products, BE.EP.DR