CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
He holds a degree in Pharmacy and Biochemistry from the Pontifical Catholic University of Rio Grande do Sul (2002), a master's degree (2005) and a doctorate (2007) in Pharmacology from the Faculty of Medicine of Ribeirão Preto, University of São Paulo and a postdoctoral degree from the Institute of Infection. , Immunity and Inflammation - University of Glasgow. He is currently Associate Professor at the Department of Pharmacology at FMRP-USP. Member of the Brazilian Society of Experimental Pharmacology and Therapeutics, of the Brazilian Society of Immunology and of the British Society for Immunology. He has experience in immunopharmacology and immunoregulation. His line of research aims to understand the cellular and molecular mechanisms that regulate inflammation and the immune response and how these can be used as therapeutic targets for the treatment of inflammatory diseases. (Source: Lattes Curriculum)
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Immune based therapeutics such as checkpoint inhibitors have proven to work across several cancer types and the potential impact novel immuno-oncology targets can have on inducing anti-cancer responses, either as standalone, or as combination/adjuvant therapies is great. Thus, our central overriding scientific focus is to discover and validate immunoregulatory targets with the potential t…
A more recent global health threat or outbreak in the course of the respiratory disease that was named Coronavirus Disease 2019 (COVID-19), is qualified by the virus called SARS-CoV-2. Scientists in basic and clinical areas around the world are having significant effects on the understanding of the pathophysiology and the investigation or effect of drugs with antiviral action and the repo…
Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowled…
The proposed application aims to consolidate a collaboration between two well-established research groups at the University of São Paulo, Brazil, and the University of Manchester, UK. Here, we propose visits and exchange of faculty staff and PhD students, which will allow us to develop qualitatively ongoing projects, provide training to postgraduate students through seminars and workshops…
(Only some records are available in English at this moment)
Th17 lymphocytes are essential cells for the homeostasis of the organism. However, research has shown that due to the action of cytokines and other inducing factors, such cells can acquire a more pathogenic phenotype, which is directly related to the genesis of several autoimmune diseases, such as multiple sclerosis. It is known that after activation of CD4 T lymphocytes, they undergo met…
Leishmaniasis is a disease caused by several species of protozoa of the genus Leishmania, obligate intracellular parasites of cells of the mononuclear phagocytic system, which cause different clinical symptoms of the disease. Brazil is the country with the highest rates of the disease in Latin America, with cutaneous leishmaniasis being predominant among cases. Currently, the treatment of…
Regulatory T lymphocytes are essential cells in immune homeostasis and in maintaining self-tolerance. These cells are characterized by expressing the FoxP3 transcription factor, which is critical in their development and suppressive function. Therefore, there is considerable interest in studying the functions and mechanisms exercised by this subset of T lymphocytes. DDX41 (Probable ATP-de…
(Only some records are available in English at this moment)
Sepsis is a complex syndrome of infectious origin, causing an uncontrolled systemic inflammatory response. Sepsis has been a serious epidemiological problem for health systems around the world, both economically and socially. In 2017, an estimated 48.9 million incident cases of Sepsis were reported worldwide and 11 million Sepsis-related deaths were reported, representing 19.7% of all glo…
COVID-19, the disease caused by the SARS-CoV-2 virus, is a major cause of public health concern worldwide. Scientists in basic and clinical areas around the world are having significant effects on the understanding of the pathophysiology and the investigation or effect of drugs with antiviral action and the repositioning of drugs that perform anti-inflammatory action, and there is still n…
Nucleic acids are essential carriers of genetic information of living organisms, however, it is known that tissue damage and cell death may result in release of DNA fragments, which in turn may directly activate the immune response. In this context, the adaptor protein STING (STimulator of INterferon Genes) was reported to be an important intracellular sensor for foreign and self-cytoplas…
(Only some records are available in English at this moment)
Th17 cells comprise a subpopulation of CD4 T cells widely described to mediate inflammation in autoimmune diseases. Over the last few years, a range of studies evidenced external and intrinsic factors regulating the transcriptional profile of Th17 cells, thereby affecting their pathogenic potential and revealing their context-dependent plasticity. The adaptor protein STING has been report…
Psoriasis is a chronic inflammatory skin disease with hyperproliferation of keratinocytes and a massive accumulation of inflammatory cells in the dermis. The pathogenesis of psoriasis is very complex, involving genetic and environmental factors, however, the exact mechanism of the disease remains poorly understood. We evaluated different public transcriptomics datasets from psoriatic pat…
Pyruvate kinase type M2 (PKM2) is an enzyme that regulates the final step of glycolysis - converting phosphoenolpyruvate (PEP) in pyruvate - that has a critical role in regulating metabolism and function of immune cells. However, the role of PKM2 in the regulation of neutrophils' functions remains poorly understood. We proposed to investigate the contribution of PKM2 to neutrophil activat…
T regulatory (Tregs) and T helper 17 (Th17) cells have distinct roles in autoimmune pathology. Th17 cells are the major lymphocyte subset that orchestrates the self-reactive tissue injury, while Treg cells are responsible for suppression of the immune response. Thus, the identification of intracellular signalling pathways that regulate the differentiation of Treg and/or Th17 cells could b…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 19 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 39 / 36 | All research grants and scholarships |
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