CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
He holds a degree in Pharmacy and Biochemistry from the Pontifical Catholic University of Rio Grande do Sul (2002), a master's degree (2005) and a doctorate (2007) in Pharmacology from the Faculty of Medicine of Ribeirão Preto, University of São Paulo and a postdoctoral degree from the Institute of Infection. , Immunity and Inflammation - University of Glasgow. He is currently a Full Professor at the Department of Pharmacology at FMRP-USP. Member of the Brazilian Society of Experimental Pharmacology and Therapeutics and the Brazilian Society of Immunology. He has experience in immunopharmacology and immunoregulation. His line of research aims to understand the cellular and molecular mechanisms that regulate inflammation and the immune response and how these can be used as therapeutic targets for the treatment of inflammatory diseases. (Source: Lattes Curriculum)
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The "Transitions" International Research Center focuses on interdisciplinary efforts to tackle complex global challenges. Spanning fields like humanities, biology, oceanography, quantum technologies, environmental science, and computational methodologies, the goal is to foster significant scientific breakthroughs and prepare a new generation of scientific leaders. The center's structure i…
Imaging technologies allow researchers to study from cell and molecular biology to complex biological and pathophysiological systems, contributing significantly to the state of the art in research and to obtaining new insights into scientific and medical problems and challenges not accessible in other ways. In this sense, there is an immense demand for innovation in super-resolution micro…
(Only some records are available in English at this moment)
The proposed application aims to consolidate collaboration between two well-established research groups at the University of São Paulo, Brazil, and the University Medicine of the Johannes-Gutenberg University Mainz, Germany. Here, we propose visits and exchanges of faculty staff, post-docs, and Ph.D. students, which will allow us to develop qualitatively ongoing projects, provide training…
(Only some records are available in English at this moment)
Psoriasis is a systemic inflammatory disease, primarily affecting the skin. It is characterized by hyperactivation and high proliferation of keratinocytes, along with an increased infiltration of inflammatory cells in the skin. Despite recent advancements in understanding the pathophysiology and treatment of the disease, the mechanisms of disease development and chronicity remain poorly u…
p53 is a transcription factor necessary for maintaining the integrity of the genome, and theactivation of its pathway is triggered through signals of cellular stress and genomic instability, which act on specific mechanisms that define the cell's fate, such as blocking the cell cycle, senescence, DNA repair and apoptosis. In turn, the STING protein (STimulator of INterferonGenes) plays an…
(Only some records are available in English at this moment)
Regulatory T lymphocytes (Tregs) are CD4+ T cells characterized by the expression of the transcription factor Foxp3. Tregs have the role of maintaining peripheral immune self-tolerance, preventing the development of autoimmune diseases, as well as suppressing exacerbated immune responses. The DDX41 protein (Probable ATP-dependent RNA helicase DDX41) is an RNA helicase member of the DEAD b…
(Only some records are available in English at this moment)
FoxP3+ regulatory T cells (Tregs) play crucial in maintaining immune system homeostasis. However, the molecular signaling mechanisms that drive Treg cell proliferation, differentiation, and function remain not fully understood. The Extracellular Signal-Regulated Kinase 5 (ERK5) is an atypical member of the mitogen-activated protein kinase (MAPK) family protein with canonical kinase functi…
Regulatory T lymphocytes (Tregs) are critical immunosuppressive cells that are crucial in regulating inflammatory responses and maintaining immune homeostasis. Understanding the mechanisms involved in the differentiation, activation, function and stability of Tregs can provide novel therapeutic strategies to halt autoimmune diseases. Immune cells express pattern recognition receptors (PRR…
Th17 cells comprise a subpopulation of CD4 T cells widely described to mediate inflammation in autoimmune diseases. Over the last few years, a range of studies evidenced external and intrinsic factors regulating the transcriptional profile of Th17 cells, thereby affecting their pathogenic potential and revealing their context-dependent plasticity. The adaptor protein STING has been report…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing grants |
| 9 / 9 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 33 / 30 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 60 / 57 | All research grants and scholarships |
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