He holds a degree in Pharmacy and Biochemistry from the Pontifical Catholic University of Rio Grande do Sul (2002), a master's degree (2005) and a doctorate (2007) in Pharmacology from the Faculty of Medicine of Ribeirão Preto, University of São Paulo and a postdoctoral degree from the Institute of Infection. , Immunity and Inflammation - University of Glasgow. He is currently Associate Professor at the Department of Pharmacology at FMRP-USP. Member of the Brazilian Society of Experimental Pharmacology and Therapeutics, of the Brazilian Society of Immunology and of the British Society for Immunology. He has experience in immunopharmacology and immunoregulation. His line of research aims to understand the cellular and molecular mechanisms that regulate inflammation and the immune response and how these can be used as therapeutic targets for the treatment of inflammatory diseases. (Source: Lattes Curriculum)
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The proposed application aims to consolidate collaboration between two well-established research groups at the University of São Paulo, Brazil, and the University Medicine of the Johannes-Gutenberg University Mainz, Germany. Here, we propose visits and exchanges of faculty staff, post-docs, and Ph.D. students, which will allow us to develop qualitatively ongoing projects, provide training…
Immune based therapeutics such as checkpoint inhibitors have proven to work across several cancer types and the potential impact novel immuno-oncology targets can have on inducing anti-cancer responses, either as standalone, or as combination/adjuvant therapies is great. Thus, our central overriding scientific focus is to discover and validate immunoregulatory targets with the potential t…
A more recent global health threat or outbreak in the course of the respiratory disease that was named Coronavirus Disease 2019 (COVID-19), is qualified by the virus called SARS-CoV-2. Scientists in basic and clinical areas around the world are having significant effects on the understanding of the pathophysiology and the investigation or effect of drugs with antiviral action and the repo…
(Only some records are available in English at this moment)
(Only some records are available in English at this moment)
Regulatory T (Treg) cells play important role in the maintenance of immunologic tolerance and control of immune responses. The transcription factor Foxp3 is essential for the development, stability and suppressive function of Treg cells. In the last few years, it has been evidenced different metabolic pathways driving the phenotype of Treg cells, which require mitochondrial integrity and …
Regulatory T lymphocytes (Tregs) are CD4+ T cells characterized by the expression of the transcription factor Foxp3. Tregs have the role of maintaining peripheral immune self-tolerance, preventing the development of autoimmune diseases, as well as suppressing exacerbated immune responses. The DDX41 protein (Probable ATP-dependent RNA helicase DDX41) is an RNA helicase member of the DEAD b…
Macrophages are critical cells in maintaining tissue homeostasis and triggering the immune response against pathogens. Thus, macrophages can be activated by a variety of stimuli and differentiate into functionally distinct phenotypes. Many of the properties of M2-type regulatory macrophages are also characteristic of tumor associated macrophages (TAMs), creating an immunosuppressive tumor…
(Only some records are available in English at this moment)
Leishmaniasis is a disease caused by several species of protozoa of the genus Leishmania, obligate intracellular parasites of cells of the mononuclear phagocytic system, which cause different clinical symptoms of the disease. Brazil is the Country with the highest rates of the disease in Latin America, with Cutaneous Leishmaniasis being predominant among cases. Currently, the treatment of…
(Only some records are available in English at this moment)
FoxP3+ regulatory T cells (Tregs) play crucial in maintaining immune system homeostasis. However, the molecular signaling mechanisms that drive Treg cell proliferation, differentiation, and function remain not fully understood. The Extracellular Signal-Regulated Kinase 5 (ERK5) is an atypical member of the mitogen-activated protein kinase (MAPK) family protein with canonical kinase functi…
Regulatory T lymphocytes (Tregs) are critical immunosuppressive cells that are crucial in regulating inflammatory responses and maintaining immune homeostasis. Understanding the mechanisms involved in the differentiation, activation, function and stability of Tregs can provide novel therapeutic strategies to halt autoimmune diseases. Immune cells express pattern recognition receptors (PRR…
Th17 cells comprise a subpopulation of CD4 T cells widely described to mediate inflammation in autoimmune diseases. Over the last few years, a range of studies evidenced external and intrinsic factors regulating the transcriptional profile of Th17 cells, thereby affecting their pathogenic potential and revealing their context-dependent plasticity. The adaptor protein STING has been report…
Psoriasis is a chronic inflammatory skin disease with hyperproliferation of keratinocytes and a massive accumulation of inflammatory cells in the dermis. The pathogenesis of psoriasis is very complex, involving genetic and environmental factors, however, the exact mechanism of the disease remains poorly understood. We evaluated different public transcriptomics datasets from psoriatic pat…
Pyruvate kinase type M2 (PKM2) is an enzyme that regulates the final step of glycolysis - converting phosphoenolpyruvate (PEP) in pyruvate - that has a critical role in regulating metabolism and function of immune cells. However, the role of PKM2 in the regulation of neutrophils' functions remains poorly understood. We proposed to investigate the contribution of PKM2 to neutrophil activat…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 5 / 5 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 26 / 23 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 51 / 48 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID