CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas (FCA) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Professor at the State University of Campinas at the School of Applied Sciences of UNICAMP. Graduated in Physical Education by PUC-Campinas (2002) and completed master's degree (2007), doctorate (2010), and postdoctoral (2011) at the Faculty of Medical Sciences of UNICAMP and concluded post-doctorate at the École Polytechnique Fédérale de Lausanne (EPFL - Switzerland), supervised by Dr. Johan Auwerx. Dr. Ropelle is a researcher at the National Institute of Science and Technology in Obesity and Diabetes and the OCRC - Center for Research on Obesity and Comorbidities (CEPID / FAPESP). Currently, he is coordinating a thematic research project at FAPESP. He has experience in the molecular biology of exercise, investigating the effects of exercise in mouse models of obesity and aging. (Source: Lattes Curriculum)
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Excessive consumption of saturated fat stimulates neuroinflammation and alters the mitochondrial activity in hypothalamic tissue, contributing to increased signals orexigenic and anti-thermogenic, leading to the obese phenotype. In this context, theactivity of the coenzyme nicotinamide adenine dinucleotide (NAD) can be considered a promising therapeutic target, as it has a notable effect …
Excessive consumption of saturated fat alters the functionality of hypothalamic neurons that control energy homeostasis, directly contributing to the onset of the obese phenotype. Mitochondrial activity in subpopulations of hypothalamic neurons is closely related to the control of food intake and energy homeostasis. Consumption of high fat diets promotes deleterious signals that alter the…
The prevalence of overweight and obesity is increasing over the years and one of the main causes is the inappropriate lifestyle including overnutrition and sedentarism. Excessive consumption of saturated fat alters the functionality of hypothalamic cells that control whole-body energy homeostasis. High-fat diets can affect mitochondrial activity in microglia and neurons in the hypothala…
In the last two decades, neuroinflammation was considered a biological response that was only a supporting factor in the etiopathogenesis of Alzheimer's Disease. However, preclinical studies and more recent studies confirm the involvement of the immune system in the pathogenesis of Alzheimer's Disease. In this context, cytokine-10 (IL-10) came to be considered as a key molecule in the con…
Mitonuclear imbalance and UPRmt (mitochondrial Unfolded Protein Response) are cellular phenomena activated under stress conditions and involving mitochondrial metabolism. These responses are largely related to mitochondrial biogenesis, improved mitochondrial function and cell metabolism, and increased longevity in several organisms. Mitonuclear imbalance is characterized by the alteratio…
(Only some records are available in English at this moment)
The intestine is an organ that significantly influences the immune response and other systemicresponses. However, several factors can impact its functionality and alter the microbiota composition and intestinal activity. Individuals with obesity have an imbalance of pro-inflammatory and anti-inflammatory bacteria, modifying the content and activity of tightjunction proteins, compromising …
Liensinine is an alkaloid belonging to the isoquinoline class, obtained fromNelumbo Nucifera Gaertn seed. This substance is extensiveconsumed in Asian countries and with reports of several positive impacts onhealth. Liensinin has recently been studied due to itsanti-inflammatory, antioxidant and anti-apoptotic properties. However, theThe impact of liensinin on mitochondrial metabolism is …
The skeletal muscle plays multiple functions in the human body, including movement production, posture maintenance, energy storage, metabolic control, and body temperature regulation, among others. Therefore, the maintenance or increase of muscle mass can be considered crucial in various situations, whether pathological or related to physical performance. In this context, ActRIIB, a recep…
(Only some records are available in English at this moment)
The hypothalamus plays an important role in the regulation of energy and homeostasis. This structure of the central nervous system is responsible for integrating signals from peripheral hormones, including insulin and leptin, which have a decisive role in controlling food intake and energy expenditure. Subpopulations of neurons located in the arcuate nucleus of the hypothalamus (ARC) are …
(Only some records are available in English at this moment)
Obesity is a metabolic syndrome caused by an imbalance between energy expenditure and consumption, where the hypothalamus play a major role in appetite control and energy homeostasis. Caenorhabiditis elegans is a nematode that can be as obesity model due they fatty acid metabolism. Mitochondria is an important multifunctional organelle related to energy metabolism through ATP production t…
Obesity is classified as a low-grade chronic inflammation, accompanied by resistance to insulin and leptin, hormones directly associated with energy homeostasis. Mitochondrial activity in hypothalamic arcuate nucleus neurons is closely related to the control of food intake and energy homeostasis. Mitochondria is a dynamic organelle and changes its conformation according to cellular energe…
The aging process is characterized by a progressive loss of physiologic integrity, leading to impaired function, reducing the physical and mental capacity, increasing the risk of disease and finally increasing vulnerability to death. Changes in the body composition may influence the lifespan, once there is an increasing in the fat mass and a decrease in muscle mass during the aging proce…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 7 / 7 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 26 / 23 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 45 / 42 | All research grants and scholarships |
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