CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Full Professor in the Department of Physiology and Biophysics of the Institute of Biomedical Sciences (ICB) at the University of São Paulo (USP). He coordinates the Laboratory of Neuroendocrinology and Metabolism (LaNeM; https://sites.usp.br/lanem/). He holds a master's degree in Food Sciences (2002-2005) and a doctorate in Morphofunctional Sciences (2005-2008) from the University of São Paulo, and completed a postdoctoral fellowship at the University of Texas Southwestern Medical Center (2008-2011). His research focuses on how neural circuits that regulate energy and glucose homeostasis are affected by the action of various hormones, such as leptin and GH, among others. He has published more than 180 scientific articles, including more than 75 as last/senior author. José Donato Jr. has advised 10 doctoral theses, four master's students, and nine postdoctoral fellows. He has received several national and international awards, including a Return Home Fellowship (from IBRO), Early Investigators Awards (from the Endocrine Society), ASPIRE Young Investigator Research Awards in Endocrinology (from Pfizer Inc.), the 2019 Excellence Award for New Leadership in Research (from the University of São Paulo), and advisor for the winning thesis award for Outstanding Thesis in Biological Sciences from the University of São Paulo (2019). He is currently coordinating his third FAPESP Thematic Research Grant and is a principal investigator at the INCT (National Institute of Translational Neuroscience). He is a member of the Advisory Committee (BF) Biophysics, Biochemistry, Pharmacology, Physiology, and Neurosciences of the CNPq (National Council for Scientific and Technological Development). He is a member of several scientific societies, including the Endocrine Society, the Society for Neuroscience, the Pan American Neuroendocrine Society, the European Society of Endocrinology, and the Brazilian Society of Endocrinology and Metabolism. He is currently an associate editor of the journal Endocrinology and head of the Department of Physiology and Biophysics. (Source: Lattes Curriculum)
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The somatotrophic axis is composed of specific neural populations (including cells that express the neuropeptides somatostatin and growth hormone-releasing hormone - GHRH), pituitary cells that produce growth hormone (GH), and GH target cells, particularly hepatocytes, which are responsible for secreting insulin-like growth factor 1 (IGF-1) in response to variations in the pattern of GH s…
The growth hormone (GH) is secreted by the anterior pituitary gland and is related to the regulation of several important physiological functions, such as cell proliferation, tissue growth, protein synthesis, carbohydrate and lipid metabolism, among others. Classically, the main target tissues of GH are the liver, skeletal muscle, bones and adipose tissue which, taken as a whole, were bel…
The growth hormone (GH) is secreted by the anterior pituitary gland and is related to the regulation of several important physiological functions, such as cell proliferation, tissue growth, protein synthesis, carbohydrate and lipid metabolism, among others. Classically, the main target tissues of GH are the liver, skeletal muscle, bones and adipose tissue which, taken as a whole, were bel…
(Only some records are available in English at this moment)
The Minispec LF50 (compact magnetic resonance device), manufactured by Bruker, allows the analysis of the body composition of mice up to 60 grams (therefore it is not compatible with rats) using an MRI method, but without generating images. The data provided by the equipment refers to the amount of fat, lean mass and body water in the analyzed animal, in relation to its body weight. Analy…
GH is the most abundant factor secreted by the pituitary gland and plays an important role controlling somatic and tissue growth, as well as cell proliferation and differentiation. Despite the presence of the GH Receptor (GHR) in the brain, little is known about the effects of this hormone on the nervous system. Thus, we propose in this project that GH has a previously unrecognized role i…
Weight regain frequently follows interventions that reduce body weight, leading to a failure in long-term obesity treatment. Inhibitory proteins of the leptin signaling pathway, such as the suppressor of cytokine signaling 3 (SOCS3), have been studied in conditions that predispose animals to obesity. However, whether SOCS3 modulates post-restriction hyperphagia and weight regain remains u…
(Only some records are available in English at this moment)
The study of feeding behaviours and energy metabolism is complex and involves many biological systems. In regards of that, the neural control of such parameters comprises different nuclei and brain circuits with a significant contribution from areas such as the extended amygdala (EAc) and the parabrachial nucleus (PBN).The PBN, located at the junction of the midbrain and pons, acts alongs…
Growth hormone (GH) has several metabolic effects, including an anti-insulin or diabetogenic action. Consequently, excessive GH secretion induces insulin resistance and may predispose an individual to diabetes mellitus. On the other hand, obesity is characterized by a condition of low circulating GH levels (Hjelholt et al., Endocrinology and metabolism clinics of North America 49:239-250,…
Growth hormone (GH) has several metabolic effects, including an anti-insulin or diabetogenic action. Consequently, excessive GH secretion induces insulin resistance and may predispose an individual to diabetes mellitus. In a study under review in PNAS, we show that ablation of the GH receptor (GHR) in Sim1-expressing cells, which include the hypothalamic paraventricular nucleus (PVH), led…
(Only some records are available in English at this moment)
Growth hormone (GH) is produced by the anterior pituitary gland and when released into the circulation, it acts on its target tissues. GH secretion is regulated by two hypothalamic hormones: GH-releasing hormone (GHRH) with a stimulating action and somatostatin (SST) with an inhibitory action on GH secretion by the pituitary gland (Hataya et al., 2001). GH has some functions in metabolism…
Reproduction plays a fundamental role in the maintenance of species, making it important to understand aspects involving reproductive processes. In the hypothalamus, nuclei such as the hypothalamic arcuate (ARH), anteroventral periventricular, and anterior periventricular (AVPV/PeN) nuclei are prominent in controlling reproduction. These nuclei contain neurons expressing the leptin recept…
Reproductive activity is coordinated by the interaction between the hypothalamic-pituitary-gonadal (HPG) axis, hormone secretion and neuronal stimuli. The gonadotrophic hormones, among other pituitary hormones, act in the gonads through the bloodstream so that gametogenesis and secretion of gonadal hormones are maintained in a proper way to propitiate reproduction. It is known that altera…
(Only some records are available in English at this moment)
Obesity is strongly associated with a variety of adverse health outcomes and the increase in childhood obesity is particularly alarming. More than 42 million children under 5 years of age are estimated to be overweight (World Health Organization) and childhood obesity tracks strongly with adolescent and adulthood obesity. Of particular concern is a growing prevalence of obesity in women o…
Approximately 17% of U.S. children and adolescents are obese, and are thus at high risk of developing further complications in adulthood. Animal models recapitulate epidemiological observations in humans that rapid early growth rates (1-3 weeks in rodents and 1-2 years of age in children) are associated with later obesity risk, independent of birth weight. Using the mouse model system, th…
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