CV Lattes
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Universidade de São Paulo (USP). Faculdade de Zootecnia e Engenharia de Alimentos (FZEA) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Biological Sciences from PUCRS-Brazil, has a master's degree in Genetics and Applied Toxicology from ULBRA-Brazil, a doctorate in Biomedical Sciences from Colorado State University-USA, post-doctorate at the University of São Paulo and free professor at the University of São Paulo. I am currently an associate professor at the Department of Veterinary Medicine at the Faculty of Animal Science and Food Engineering at the University of São Paulo. My research focuses on understanding intercellular communication within the ovarian follicle, oviduct, and uterus. The ultimate goals are to decode the role of extracellular vesicles during folliculogenesis and early embryo development in order to understand female reproductive biology, develop new biomarkers and supplements for use in the in vitro production system. Furthermore, we investigated the role of miRNAs during folliculogenesis and early embryo development in order to find new biological pathways associated with oocyte quality and embryo viability. Member of the board of directors of the Brazilian Society of Embryo Technology for the 2020-2021 biennium. (Source: Lattes Curriculum)
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In vitro production of embryos (IVP) is widely used in humans and animals as alternatives to infertility problems and a tool to increase the production efficiency of livestock animals, especially in cattle. Since its beginning, IVP relied on the constant evolution of cell culture media composition based on the observed composition of reproductive biofluids. Extracellular vesicles (EVs) ar…
In vitro production of embryos (IVP) is widely used in humans and animals as alternatives to infertility problems and a tool to increase the production efficiency of livestock animals, especially in cattle. Since its beginning, IVP relied on the constant evolution of cell culture media composition based on the observed composition of reproductive biofluids. Extracellular vesicles (EVs) ar…
In vitro production of embryos (IVP) is widely used in humans and animals as alternatives to infertility problems and a tool to increase the production efficiency of livestock animals, especially in cattle. Since its beginning, IVP relied on the constant evolution of cell culture media composition based on the observed composition of reproductive biofluids. Extracellular vesicles (EVs) ar…
Although reproductive processes are modulated by mechanisms involving endocrine cell communication, recently molecular mechanisms complementary to the endocrine ones have also been related to reproductive functions. Similar to endocrine hormone communication, there are moleculesimportant to the reproductive processes that act in a paracrine way, being carried primarily through extracellul…
Dr. Bouma has extensive experience in the study of trophoblast formation in ruminants. In its most recent studies, the CRISPR / CAS9 technique is used as a tool for genome molecular manipulation to understand pathways involved with normal or abnormal placental formation. Our intention with the coming of Dr. Bouma is to implement strategies to study the effects of in vitro embryo productio…
In 30 years, the global population growth associated with the high demand for animal protein will claim for a high evolution of the beef cattle production indexes. The increase in livestock efficiency is based on several factors, among which the reproductive index of the herd represents a great intercession of this segment. Reproductive biotechnologies are tools capable of optimizing the …
(Only some records are available in English at this moment)
In cattle, an antral follicle requires approximately 40 days to develop into a pre-ovulatory follicle. However, when the follicle is aspirated and cumulus-oocyte complexes (COCs) are placed in in vitro maturation (IVM) media, nuclear maturation occurs in less than 24 hours, resulting in a desynchronization between nuclear and cytoplasmic maturation. Cytoplasmic immaturity leads to inadequ…
A large proportion of high-production dairy cows exhibit negative energy balance (NEB) in the postpartum period. The mobilization of body reserves during this period aims to meet the energy demands of milk production. This mobilization increases metabolites such as non-esterified fatty acids (NEFAs) and beta-hydroxybutyrate (BHB). These metabolites are toxic to reproductive cells when in …
Reproductive biotechnologies such as in vitro embryo production accelerate genetic improvement, but its success is directly linked to the ability to mimic the in vivo environment. Among the events that occur during follicular maturation and oocyte growth is the intercellular communication in the follicular environment and consequently the transfer of biomolecules between somatic cells and…
(Only some records are available in English at this moment)
Beef production efficiency and reproductive system are directly influenced by nutritional factors. The factors that regulate ovarian function, embryonic quality, and the establishment of the pregnancy can be affected by energy level and body condition. During the period of pre-implantation, the embryo migrates from the oviduct to the uterus in cattle. At this time, about 40% of embryonic …
The search for reproductive biotechniques has become a mean to achieve an efficient increase in the productivity of cattle herds. Among them, in vitro embryo production stands out, a biotechnique widely used in Brazil. With this, the importance of improving this technique arises, through the study of the cellular mechanisms involved in the intercellular communication within the follicular…
(Only some records are available in English at this moment)
High-producing dairy cows often undergo a process of Negative Energy Balance (NEB). During this period, the animals experience intense mobilization of body reserves to maintain milk production and meet the energy demands of this process. During this mobilization of body reserves, the animal experiences an increase in metabolites such as non-esterified fatty acids (NEFAs), with palmitic ac…
The assessment of embryo quality is of paramount importance in the context of assisted reproductive technologies (ART) in order to optimize implantation and pregnancy outcomes. Extracellular vesicles (EVs) are involved in intercellular communication and have been identified as a potential biomarker for the non-invasive assessment of embryo quality. The objective of this project is to deve…
Embryo development occurs within a dynamic environment, characterized by molecular exchanges between the embryo and maternal structures. However, this scenario is often disrupted in vitro, where embryos can also be cultured. Consequently, the inability to fully replicate the in vivo environment likely accounts for the reduced developmental potential observed in in vitro-produced embryos, …
The livestock industry in Brazil holds a prominent global position, with a significant focus on improving efficiency. Reproductive biotechnologies, especially in vitro embryo production, have gained attention for enhancing productivity. Co-culturing with bovine oviductal epithelial cells has shown promise, as they interact with embryos and oviductal fluid, containing extracellular vesicle…
Dairy cows milk production has increased over the past decade as a result of intense genetic selection. However, the advances in genetic selection of dairy herds did not come with an improvement of reproductive parameters. Negative energy balance (NEB) during postpartum period is important risk factor in the establishment of reproductive failure in high producing dairy cows and has signif…
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 9 / 9 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 15 / 15 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 41 / 41 | All research grants and scholarships |
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