Eduardo Maffud Cilli
CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Cilli is director of Institute of Chemistry of Araraquara -UNESP. Cilli is graduate at Bacharelado Em Química from Universidade Estadual Paulista Júlio de Mesquita Filho (1989), master's at Biochemistry from Universidade Federal de São Paulo (1993) and ph.d. at Biochemistry from Universidade Federal de São Paulo (1997). Has experience in Biochemistry, focusing on Proteins, acting on the following subjects: peptide, solid phase peptide synthesis, resin, síntese de peptídeos em fase sólida and epr. (Source: Lattes Curriculum)
(Only some records are available in English at this moment)
- Application of MALDI imaging (MSI) on non-nodulated and nodulated leaves of Psychotria and Hybanthus: localization, analysis of cyclotides and its relationship with endosymbionts bacteria, BP.PD
Abstract
Some taxons of angiosperms biosynthesize peculiar substances known as cyclic peptides. The research on this class of natural products in Brazilian biodiversity species are relevant regarding the functional understanding of these molecules in plants where they occur. Being also relevant for the bioprospection of bioactive natural products, especially insecticidal, antimicrobial and antif...
- Development of multifunctional prodrugs for combination therapy against hepatocellular carcinoma and HCV, BP.DR
Abstract
Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the third leading cause of death worldwide. Alcohol and viral infections are the leading causes of this disease. About 90% of HCC cases are attributed to infection by Hepatitis B and C. Unlike HBV, there is still no vaccine capable of preventing infection by HCV. Most of therapeutic agents (anti-tumor and antiviral) ...
- Synthesis and characterization of bioconjugates containing peptides with antitumor activity, BP.IC
Abstract
Due to the low therapeutic index of cancer treatment, various researches have been conducted for the development of methods / molecules that allow cheaper therapies, faster and less uncomfortable for patients with the disease. In this project, a peptide aptamer, an antimicrobial peptide and a thiosemicarbazone be used as molecules in the development of bioconjugates, in order to increas...
- Synthesis, characterization, study of action mechanism and analysis of different release methods of pBthTX-I, in its monomeric and dimeric forms, BP.PD
Abstract
Animals venoms and poisons are a rich source of pharmacologically active substances. These molecules act independently or synergistically, binding to different cellular receptors and/or in metabolic pathways. The exploration of the mechanisms of action of toxins has proved relevant, not only for providing the molecular basis involved in the mechanism of toxicity of these molecules , as ...
- Experimental evaluation of the action of protein hydrolysates and peptides on the activity of HMG-CoA reductase and regulation of lipid metabolism genes, BP.PD
Abstract
Recent studies have shown that protein vicilin (7S) isolated from soybean (Glycine max) and cowpea beans (Vigna unguiculata, L.) and adzuki (V. angularis, L.), separately, have an effect on concentrations of cholesterol and its fractions in dyslipidemic rats. Although the mechanism of action is not yet known, we found that there were significant modifications in mRNA expression of diffe...
(Only some records are available in English at this moment)
*Updated April 20, 2019
| 1 / 1 | Ongoing research grants |
| 11 / 8 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 12 / 7 | Completed scholarships in Brazil |
| 26 / 18 | All Research Grants and Scholarships |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 23 |
| Citations | 81 |
| Cit./Article | 3.5 |
| Data from Web of Science | |
DE BARROS, NATAN ROBERTO; ROMEIRO MIRANDA, MATHEUS CARLOS; BORGES, FELIPE AZEVEDO; DE MENDONCA, RICARDO JOSE; CILLI, EDUARDO MAFFUD; HERCULANO, RONDINELLI DONIZETTI. Oxytocin Sustained Release Using Natural Rubber Latex Membranes. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, v. 22, n. 4, p. 435-444, DEC 2016. Web of Science Citations: 9. (15/02343-8, 14/17526-8)
PINHEIRO-JUNIOR, ERNESTO LOPES; BOLDRINI-FRANCA, JOHARA; PIRES DE CAMPOS ARAUJO, LUCIANA MATTOSO; SANTOS-FILHO, NORIVAL ALVES; BENDHACK, LUSIANE MARIA; CILLI, EDUARDO MAFFUD; ARANTES, ELIANE CANDIANI. LmrBPP9: A synthetic bradykinin-potentiating peptide from Lachesis muta rhombeata venom that inhibits the angiotensin-converting enzyme activity in vitro and reduces the blood pressure of hypertensive rats. Peptides, v. 102, p. 1-7, APR 2018. Web of Science Citations: 1. (14/16182-3, 14/05538-1, 13/07600-3)
LORENZON, ESTEBAN N.; PICCOLI, JULIA P.; CILLI, EDUARDO M.. Interaction between the antimicrobial peptide Aurein 1.2 dimer and mannans. Amino Acids, v. 46, n. 11, p. 2627-2631, NOV 2014. Web of Science Citations: 8. (12/15346-7)
VICENTE, EDUARDO F.; BASSO, LUIS GUILHERME M.; CESPEDES, GRAZIELY F.; LORENZON, ESTEBAN N.; CASTRO, MARIANA S.; MENDES-GIANNINI, MARIA JOSE S.; JOSE COSTA-FILHO, ANTONIO; CILLI, EDUARDO M.. Dynamics and Conformational Studies of TOAC Spin Labeled Analogues of Ctx(Ile(21))-Ha Peptide from Hypsiboas albopunctatus. PLoS One, v. 8, n. 4, APR 9 2013. Web of Science Citations: 12. (10/17662-8, 09/10997-7, 10/06526-6)
PINTO, MERI EMILI F.; NAJAS, JHENNY Z. G.; MAGALHAES, LUMA G.; BOBEY, ANTONIO F.; MENDONCA, JACQUELINE N.; LOPES, NORBERTO P.; LEME, FLAVIA M.; TEIXEIRA, SIMONE P.; TROVO, MARCELO; ANDRICOPULO, ADRIANO D.; et al. Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria. Journal of Natural Products, v. 81, n. 5, p. 1203-1208, MAY 2018. Web of Science Citations: 1. (14/50265-3, 17/17098-4, 13/07600-3)
VICENTE, EDUARDO F.; SAHU, INDRA D.; CRUSCA, JR., EDSON; BASSO, LUIS G. M.; MUNTE, CLAUDIA E.; COSTA-FILHO, ANTONIO J.; LORIGAN, GARY A.; CILLI, EDUARDO M.. HsDHODH Microdomain-Membrane Interactions Influenced by the Lipid Composition. Journal of Physical Chemistry B, v. 121, n. 49, p. 11085-11095, DEC 14 2017. Web of Science Citations: 1. (14/00206-0, 15/18390-5, 10/06526-6, 10/12953-4)
HUDARI, FELIPE F.; BESSEGATO, GUILHERME G.; BEDATTY FERNANDES, FLAVIO C.; ZANONI, MARIA V. B.; BUENO, PAULO R.. Reagentless Detection of Low-Molecular-Weight Triamterene Using Self-Doped TiO2 Nanotubes. Analytical Chemistry, v. 90, n. 12, p. 7651-7658, JUN 19 2018. Web of Science Citations: 2. (12/22820-7, 15/18109-4, 15/13359-2, 14/03679-7)
CAIAFFA, KARINA SAMPAIO; MASSUNARI, LOIANE; DANELON, MARCELLE; ABUNA, GABRIEL FLORES; LOMBARDO BEDRAN, TELMA BLANCA; SANTOS-FILHO, NORIVAL ALVES; PALOMARI SPOLIDORIO, DENISE MADALENA; VIZOTO, NATALIA LEAL; CILLI, EDUARDO MAFFUD; DUQUE, CRISTIANE. KR-12-a5 is a non-cytotoxic agent with potent antimicrobial effects against oral pathogens. BIOFOULING, v. 33, n. 10, p. 807-818, 2017. Web of Science Citations: 0. (13/24606-5, 12/15346-7)
SANTOS-FILHO, NORIVAL A.; FERNANDES, RAFAELA S.; SGARDIOLI, BRUNA F.; RAMOS, MATHEUS A. S.; PICCOLI, JULIA P.; CAMARGO, ILANA L. B. C.; BAUAB, TAIS M.; CILLI, EDUARDO M.. Antibacterial Activity of the Non-Cytotoxic Peptide (p-BthTX-I)(2) and Its Serum Degradation Product against Multidrug-Resistant Bacteria. Molecules, v. 22, n. 11, NOV 2017. Web of Science Citations: 2. (14/05538-1, 13/07600-3)
SANTOS, ADRIANO; BUENO, PAULO R.; DAVIS, JASON J.. A dual marker label free electrochemical assay for Flavivirus dengue diagnosis. BIOSENSORS & BIOELECTRONICS, v. 100, p. 519-525, FEB 15 2018. Web of Science Citations: 1. (12/22820-7)
MIRANDA, M. C. R.; PREZOTTI, F. G.; BORGES, F. A.; BARROS, N. R.; CURY, B. S. F.; HERCULANO, R. D.; CILLI, E. M.. Porosity effects of natural latex (Hevea brasiliensis) on release of compounds for biomedical applications. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v. 28, n. 18, p. 2117-2130, 2017. Web of Science Citations: 3. (15/02343-8, 11/17411-8, 12/15346-7)
LORENZON, E. N.; RISKE, K. A.; TROIANO, G. F.; DA HORA, G. C. A.; SOARES, T. A.; CILLI, E. M.. Effect of dimerization on the mechanism of action of aurein 1.2. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v. 1858, n. 6, p. 1129-1138, JUN 2016. Web of Science Citations: 7. (12/10442-8, 12/15346-7)
VICENTE, EDUARDO F.; SAHU, INDRA D.; COSTA-FILHO, ANTONIO J.; CILLI, EDUARDO M.; LORIGAN, GARY A.. Conformational changes of the HsDHODH N-terminal Microdomain via DEER Spectroscopy. Journal of Physical Chemistry B, v. 119, n. 28, p. 8693-8697, JUL 16 2015. Web of Science Citations: 5. (10/06526-6)
SANTOS-FILHO, NORIVAL A.; LORENZON, ESTEBAN N.; RAMOS, MATHEUS A. S.; SANTOS, CLAUDIA T.; PICCOLI, JULIA P.; BAUAB, TAIS M.; FUSCO-ALMEIDA, ANA M.; CILLI, EDUARDO M.. Synthesis and characterization of an antibacterial and non-toxic dimeric peptide derived from the C-terminal region of Bothropstoxin-I. Toxicon, v. 103, p. 160-168, SEP 1 2015. Web of Science Citations: 14. (14/05538-1)
MIRANDA, M. C. R.; BORGES, F. A.; BARROS, N. R.; SANTOS FILHO, N. A.; MENDONCA, R. J.; HERCULANO, R. D.; CILLI, E. M.. Evaluation of peptides release using a natural rubber latex biomembrane as a carrier. Amino Acids, v. 50, n. 5, p. 503-511, MAY 2018. Web of Science Citations: 0. (15/02343-8, 11/17411-8, 12/15346-7)
LORENZON, ESTEBAN N.; SANTOS-FILHO, NORIVAL A.; RAMOS, MATHEUS A. S.; BAUAB, TAIS M.; CAMARGO, ILANA L. B. C.; CILLI, EDUARDO M.. C-terminal Lysine-Linked Magainin 2 with Increased Activity Against Multidrug-Resistant Bacteria. PROTEIN AND PEPTIDE LETTERS, v. 23, n. 8, p. 738-747, 2016. Web of Science Citations: 5. (13/07600-3, 12/15346-7)
BOBEY, ANTONIO FERNANDEZ; FERREIRA PINTO, MERI EMILI; CILLI, EDUARDO MAFFUD; LOPES, NORBERTO PEPORINE; BOLZANI, VANDERLAN DA SILVA. A Cyclotide Isolated from Noisettia orchidiflora (Violaceae). Planta Medica, v. 84, n. 12-13, SI, p. 947+, AUG 2018. Web of Science Citations: 0. (14/50926-0, 13/07600-3, 17/17098-4)
INUI KISHI, ROSANGELA NAOMI; STACH-MACHADO, DAGMAR; SINGULANI, JUNYA DE LACORTE; DOS SANTOS, CLAUDIA TAVARES; FUSCO-ALMEIDA, ANA MARISA; CILLI, EDUARDO MAFFUD; FREITAS-ASTUA, JULIANA; PICCHI, SIMONE CRISTINA; MACHADO, MARCOS ANTONIO. Evaluation of cytotoxicity features of antimicrobial peptides with potential to control bacterial diseases of citrus. PLoS One, v. 13, n. 9, SEP 7 2018. Web of Science Citations: 1. (08/52691-9, 12/15346-7, 10/11072-4)
LORENZON, ESTEBAN N.; PICCOLI, JULIA P.; SANTOS-FILHO, NORIVAL A.; CILLI, EDUARDO M.. Dimerizatiori of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity. PROTEIN AND PEPTIDE LETTERS, v. 26, n. 2, p. 98-107, 2019. Web of Science Citations: 0. (13/07600-3, 12/15346-7)
ROS, URIS; CARRETERO, GUSTAVO P. B.; PAULINO, JOANA; CRUSCA, JR., EDSON; PAZOS, FABIOLA; CILLI, EDUARDO M.; LANIO, MARIA E.; SCHREIER, SHIRLEY; ALVAREZ, CARLOS. Self-association and folding in membrane determine the mode of action of peptides from the lytic segment of sticholysins. Biochimie, v. 156, p. 109-117, JAN 2019. Web of Science Citations: 0.
BATISTA, MARIANA NOGUEIRA; DA SILVA SANCHES, PAULO RICARDO; CARNEIRO, BRUNO MOREIRA; SILVA BRAGA, ANA CLAUDIA; FERNANDES CAMPOS, GUILHERME RODRIGUES; CHILLI, EDUARDO MAFFUD; RAHAL, PAULA. GA-Hecate antiviral properties on HCV whole cycle represent a new antiviral class and open the door for the development of broad spectrum antivirals. SCIENTIFIC REPORTS, v. 8, SEP 25 2018. Web of Science Citations: 0. (17/00287-9, 15/23244-8, 13/07600-3, 16/02174-4)
PICCOLI, JULIA; HEIN, ROBERT; EL-SAGHEER, AFAF H.; BROWN, TOM; CILLI, EDUARDO M.; BUENO, PAULO R.; DAVIS, JASON J.. Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface. Analytical Chemistry, v. 90, n. 5, p. 3005-3008, MAR 6 2018. Web of Science Citations: 8. (12/22820-7, 15/02343-8, 13/07600-3)
DE OLIVEIRA, ALINE LIMA; CILLI, EDUARDO MAFFUD; ROS, URIS; CRUSCA, JR., EDSON; LANIO, MARIA ELIANA; ALVAREZ, CARLOS; SCHREIER, SHIRLEY; PERTINHEZ, THELMA AGUIAR; SPISNI, ALBERTO. Insights on the structure-activity relationship of peptides derived from Sticholysin II. PEPTIDE SCIENCE, v. 110, n. 5, SI, SEP 2018. Web of Science Citations: 1.
Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação PCT/BR2016/050337 - Universidade Estadual Paulista (UNESP). Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - December 2016, 19
PEPTÍDEO SINTÉTICO DIMÉRICO ANTIMICROBIANO E ANTIFÚNGICO E SEUS USOS BR1020140217614 - Universidade Estadual Paulista (UNESP). Esteban Nicolás Lorenzon; Eduardo Maffud Cilli; Matheus Aparecido dos Santos Ramos; Taís Maria Bauab - September 2014, 03
PROCESSO DE OBTENÇÃO DE PEPTÍDEOS DIMÉRICOS (p-BthTX-I)2, PEPTÍDEOS DIMÉRICOS (p-BthTX-I)2 E SEU USO COMO ANTIMICROBIANO BR1020140315829 - Universidade Estadual Paulista (UNESP). Esteban Nicolás Lorenzón; Eduardo Maffud Cilli; Matheus Aparecido dos Santos Ramos; Norival Alves Santos Filho; Taís Maria Bauab - December 2014, 17
PROCESSO DE OBTENÇÃO DE MEMBRANA POROSA DE LÁTEX NATURAL, MEMBRANA POROSA DE LÁTEX NATURAL E SEUS USOS BR1020150320477 - Universidade Estadual Paulista (UNESP). EDUARDO MAFFUD CILLI; RONDINELLI DONIZETTI HERCULANO; MATHEUS CARLOS ROMEIRO MIRANDA - December 2015, 21