CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a Bachelors degree in Fundamental Sciences for Health (20062009) and a Direct PhD in Sciences Human Physiology (20102014), both from the Institute of Biomedical Sciences, University of São Paulo (ICB-USP). During the PhD, completed a research internship in the Division of Nephrology at Massachusetts General Hospital, Harvard Medical School.Completed a postdoctoral fellowship funded by FAPESP at the University of São Paulo Medical School (20152018) and a postdoctoral research internship at the University of Toronto, Li Ka Shing Knowledge Institute, St. Michaels Hospital (20162017).Currently serves as an Assistant Professor (MS 3.2) in the Department of Physiology and Biophysics at the Institute of Biomedical Sciences, University of São Paulo. Works in the field of Organ and Systems Physiology, with an emphasis on Renal Physiology, investigating cellular, molecular, and epigenetic mechanisms involved in the development and progression of chronic kidney disease, as well as glucose metabolism and renal metabolic reprogramming, including studies in experimental models of obesity and diabetes. (Source: Lattes Curriculum)
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Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease in the world. Inflammation has an early onset in most renal failures, initially as a protective mechanism. However, this inflammatory state can exceed the physiological limit, becoming chronic and with undesirable systemic consequences. The pro-inflammatory and pro-fibrotic processes that occur during the develo…
Diabetic Kidney Disease (DKD) and Focal and Segmental Glomerulosclerosis (FSGS) are the main causes of Chronic Kidney Disease (CKD), a condition characterized by progressive loss of renal function and the presence of proteins in the urine. The loss of proteins is closely associated with the dysfunction of podocytes, highly specialized cells that make up the glomerular filtration barrier. …
Diabetic Kidney Disease (DKD) is the leading cause of end-stage renal disease worldwide. It results from chronic hyperglycemia, inflammation, oxidative stress, and hemodynamic changes that lead to fibrosis and renal dysfunction. Obesity and type 2 diabetes further increase the risk through mechanisms such as lipotoxicity and mitochondrial dysfunction. Proximal tubular cells, which play a …
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. Both type 1 and type 2 diabetes lead to the development of DKD; however, the increase in the number of individuals with obesity and type 2 diabetes has been one of the major contributors to the rising prevalence, incidence, and number of deaths from chronic kidney disease. The use of experimental models that r…
Type 2 diabetes mellitus (DMT2) is a chronic metabolic disease characterized by increased blood glucose levels. In DMT2, hyperglycemia is the result of impaired insulin signaling in tissues, which leads to an excess of this hormone in the blood - a metabolic condition known as insulin resistance. The prevalence of DMT2 is higher in men than in women, who are more resistant to the developm…
Diabetic kidney disease (DKD) is a complication that develops in approximately 40% of patients with type 2 diabetes mellitus (T2DM) and represents one of the main causes of progression to chronic kidney disease (CKD). It is known that inflammation, both systemic and local, plays an important role in the development of DKD. Macrophages are among the main types of immune cells present in ki…
Diabetic kidney disease (DKD) is the leading cause of end stage kidney disease in the world. Currently, treatments are mainly based on blood glucose and blood pressure control, but clinical studies suggest that they have a mild or neutral positive effect on the progression of DKD once renal dysfunction has already been established. Hyperglycemia, one of the main supporting elements in the…
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The complement system is a conserved part of innate immunity, critical for protecting the body against pathogens, maintaining tissue homeostasis and orchestrating adaptive immune responses. The kidneys are a main target organ for complement induced injury and are also a major source of local complement factor production. It has been shown that not only systemic, but also local and intrace…
The overall scope of the problem is that as the US population lives longer, kidney disease becomes more abundant. Elderly patients in particular face worse disease outcomes and they are now the largest group to undergo first-time dialysis. The goal of this proposal is to prove that aged terminally differentiated glomerular epithelial cells, called podocytes, are central to the many glomer…
Introduction: Diabetic nephropathy (DN) is the most common cause of endstage renal disease worldwide and new therapies are urgently needed. The studies focusing in new mechanistic insights into the (patho)physiology of renal injury in diabetes, as well as potentially leading to the development of novel therapeutic interventions in DN, through targeting non-coding RNA-regulated epigenetic …