CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor's at Biology from Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP (1968), master's at Biologia Celular from Universidade de São Paulo - USP 1987) and doctorate at Histology from Universidade de São Paulo - USP(1993). He is currently full professor at Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP. Has experience in Morphology, focusing on Histology, acting on the following subjects: inflammation cells (mast cells and leukocytes) and annexin 1 and galectin 1 proteins, . (Source: Lattes Curriculum)
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Annexin A1 (ANXA1) is a 37 kDa protein that exhibits calcium and membrane phospholipid binding sites and is involved in the inhibition of glucocorticoid-induced eicosanoid and phospholipase A2 synthesis, which gives antiinflammatory properties to this protein. Several studies have shown the protective effect of ANXA1 on acute and chronic inflammatory processes in response to infection and…
Biocompatibility of two newly developed porcine skin scaffolds was assessed after 3, 14, 21 and 90 days of implantation in rats. Both scaffolds showed absence of cells, preservation of ECM and mechanical properties comparable to non-decellularised skin before implantation. Host cell infiltration was much prominent on both scaffolds when compared to Permacol (surgical control). At day 3, t…
. The protein annexin A1 (AnxA1) acts on the resolution of inflammation and has beenassociated to gastrointestinal mucosa protection. Several surveys have shown the protective effect ofAnxA1 in acute inflammation, regulating the influx of neutrophils, monocytes and mast celldegranulation and, in chronic inflammatory processes acting in response to infections and neoplasias. Forthese reaso…
(Only some records are available in English at this moment)
Studies that allow the understanding of mechanisms that play a role in placental pathophysiology are extremely relevant and may help to understand the many complications that compromise pregnancy and fetal health. Known factors that may compromise the development of placenta and, consequently, the fetus include: nutrient deficiency, glycemic disorders, viral and bacterial infections, hype…
Angiogenesis is the formation of new blood vessels from pre-existing vasculature, and the vascular endothelial growth factor (VEGF) is a key regulator in this process, being a survival factor for endothelial cells, stimulating the origin of new microvascular network. The angiogenesis process is extremely necessary for the success of transplants, regeneration and repair of damaged tissues,…
Tissue Engineering is an important field of modern medicine that develops biological substitutes for tissues and organs. The advances in this area have led to the development of various products, both synthetic and biological, with the goal of improving the quality of life of the patient, either through restoration and maintenance of tissues or improving the functions of tissues and trans…
(Only some records are available in English at this moment)
Studies that allow the understanding of the mechanisms that play a role in placental pathophysiology are extremely relevant and may help to understand the many complications that compromise pregnancy and fetal health. Viral infections during pregnancy have been demonstrated to cause spontaneous abortions, stillbirth, fetal infection, intrauterine growth restriction (IUGR), preterm prematu…
The clinical impact of various lesions such as loss of skin due to non-healing ulcers, abdominal wall defects resulting from trauma, extensive tumor resection, necrotizing infections, or extensive burns associated with limited use of autografts, has led an enormous advance in the development of tissue-engineered skin derivatives or acellular matrices. Designed as skin substitutes, both ep…
In tills project we will address the question of LC1 localization in mast cell (MC) using an ultra structural approach, combining histological techniques with electron microscopic analysis. In particular we will use not only isolated MC but, more importantly, tissues rich in MC in the absence or presence of inflammation. In tile latter samples we will try to correlated the extent of MC in…
| 1 / 1 | Ongoing research grants |
| 16 / 10 | Completed research grants |
| 32 / 18 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 53 / 32 | All research grants and scholarships |
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