Abstract
Myelodysplastic syndrome (MDS) is a heterogeneous group of hematological malignancies characterized by ineffective hematopoiesis, cytopenias and risk of progression to acute myeloid leukemia, which mainly affects the elderly population. Mitochondrial dysfunction and stem cell exhaustion are two features of aging commonly found in MDS. Clonal hematopoiesis is perpetuated by inflammation an…