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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Fausto Bruno dos Reis Almeida in research grants and scholarships supported by FAPESP.
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Avian Influenza Viruses (AIVs) is one of the widely spread viruses in poultry, which threats the global economy and healthy security. Extracellular vesicles (EVs) play important role in the biology of all domains of life. During viral infections, the mechanisms by which EVs from infected cells modulates the host immune system are still poorly explored. Our groups have concentrated efforts…
Cryptococcus neoformans is an encapsulated fungal pathogen that causes fatal meningoencephalitis. Extracellular vesicles (EVs) play an important role in the biology of all domains of life, including fungi. In C. neoformans, they are required for the trafficking of molecules across the capsule and cell wall. The mechanisms by which C. neoformans modulate the immune response are still obscu…
Extracellular Vesicles (EVs) play an important role in export systems. They act as vehicles for the transference of complex cargoes with broad biological functions. These vesicles cross the fungal cell wall to reach the extracellular space and transport its major virulence factors contributing to fungal infection outcomes. Since we had the FAPESP young investigator grant phase 1, our grou…
Iron has a central position at the pathogen-host interface. Mammals have high affinity systems for iron sequestration from pathogens, and pathogen resistance to iron deprivation is a virulence factor. During iron deprivation, members of the Paracoccidioides complex, etiological agents of paracoccidioidomycosis disease induce iron acquisition systems, including siderophores production, hem…
Cryptococcus neoformans is the causative agent of cryptococcosis and a major pathogen for immunosuppressed individuals. C. neoformans represents a unique model in cell biology studies since it is the only eukaryotic pathogen with a polysaccharide capsule, furthermore produces vesicles containing its major virulence factor. These vesicles cross the cell wall to reach the extracellular spac…
Candida auris is a newly discovered pathogen that has attracted international media attention due to its multidrug resistance to classic antifungals used in the treatment of candidiasis and prevalence in intensive care units. The successful establishment of the infection is due to strategies developed by this fungus to deal with defensive molecules secreted by the host. During the course …
The study of fungal extracellular vesicles (EVs) is crucial to understanding the complex pathogen-host interactions, particularly in the face of the growing challenge of antifungal resistance. EVs play multifaceted roles, transporting biologically active molecules and influencing key biological mechanisms. A growing number of studies have investigated the occurrence of a phenomenon known …
Fungal infections are associated with around 1.6 million deaths per year, affecting more than 1 billion people. Among the main pathogenic fungi, Cryptococcus spp., Aspergillus spp. and Candida spp. are notable for their high mortality. Extracellular vesicles (EVs) are structures formed by a lipid bilayer that carry several biomolecules that play important roles in fungal pathophysiology. …
(Only some records are available in English at this moment)
Cell-to-cell communication is essential for the pathogenic fungi adaptation to hostile environments and stress conditions, such as changes in pH, temperature, radiation and the presence of inhibitors, which facilitates their survival and successful infection. Cryptococcus neoformans, which causes cryptococcosis, a serious and potentially fatal disease, especially in immunecompromised indi…
Mechanisms involved in cell-cell communication are important for pathogenic fungi during their adaptation to hostile environments and harsh conditions (differences in pH, incubation temperature, radiation, and inhibitory molecules), allowing their survival in the host and consequently their success in infection. This interaction, even at a distance, can regulate various processes, some of…
Pathogenic fungi cause thousands of deaths each year. Extracellular vesicles (EVs) are structures formed by a lipid bilayer that carry in their interior proteins, nucleic acids, carbohydrates, pigments, and lipids. EVs are related to biofilm formation, stimuli of cytokine production, virulence transference, antifungal resistance, and cell-cell communication, contributing to pathogenicity …
(Only some records are available in English at this moment)
Cell-to-cell communication is essential for pathogenic fungi to adapt to environmental stressors such as pH changes, temperature shifts, radiation, and inhibitors. Cryptococcus neoformans, the pathogen responsible for cryptococcosis -a serious and potentially fatal disease- uses extracellular vesicles (EVs) for cellular signaling. These EVs, identified in fungi like Candida, Aspergillus, …
Cancer represents a set of malignant neoplastic diseases and is a leading cause of death worldwide. Kidney cancer represents 4.6% of the total number of cancer diagnoses in 2020, according to WHO. Despite the low percentage, it represents approximately 430,000 cases, which 90% correspond to Renal Cell Carcinoma (RCC). This neoplasm originates in the tubular epithelial cells of the nephron…
Cryptococcus neoformans is the causative agent of cryptococcosis and a major pathogen for immunosuppressed individuals. C. neoformans represents a unique model in cell biology studies because it is the only eukaryotic pathogen with a polysaccharide capsule, furthermore produces vesicles containing its major virulence factor. These vesicles cross the cell wall to reach the extracellular sp…
| 3 / 3 | Ongoing grants |
| 7 / 2 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 15 / 15 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 34 / 29 | All research grants and scholarships |
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