CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Medicine from Universidade Federal do Rio Grande do Sul (1981) and got his Phd in Pharmacology from the Universidade de São Paulo (1987). At the moment is Full Professor of Pharmacology at the Faculdade de Medicina de Ribeirão Preto, Universidade de São Pauo. Has experience in Pharmacology, focusing on Neuropsicopharmacology, acting on the following subjects: cannabdiol, nitric oxide, anxiety, depression, glutamate and serotonin. He is a member of the Brazilian and São Paulo Academies of Science.javascript:void(0) (Source: Lattes Curriculum)
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Among the more than 200 phytocannabinoids present in the Cannabis sativa plant, the one that has received the most attention regarding therapeutic potential is cannabidiol (CBD). The number of scientific works aimed at investigating this potential has been increasing exponentially. Results obtained in recent decades suggest that CBD may be useful in a large number of neuropsychiatric diso…
The need to develop new therapeutic targets for the treatment of neuropsychiatric disorders is a consensus in the scientific literature. Endocannabinoids (eCBs) and nitric oxide (NO) have been proposed as two of these possible targets. Studies from our group have disclosed the therapeutic potential of drugs that interfere with these two atypical neurotransmitters in anxiety, depressive, p…
In the last 15 years our group has contributed to a better understanding of the role of nitric oxide (NO) and endocannabinoids (eCBs) in physiological and pathophysiological processes of the central nervous system. We showed that manipulations of these atypical neurotransmitters are able to change behavioral and autonomic responses of laboratory animals submitted to animal models of anxie…
(Only some records are available in English at this moment)
Interactions between the gut microbiota and the Central Nervous System (CNS) play a significant role in Autism Spectrum Disorder (ASD), highlighting the Gut-Brain-Microbiota Axis as a crucial pathway for understanding this condition. In this regard, there is growing interest in therapeutic approaches for ASD through the manipulation of the microbiota, and this project proposes cannabidiol…
Neurodevelopment variations have been associated to pathopsysiology of schizophrenia. Variations in the period of brain maturation, specially during the first childhood, further the schizophrenia appearance on the beginning of adulthood. The interference in these variations can be a new and important strategy to prevent this disease. Pre-clinic and clinic studies suggest a cannabinoid com…
Cannabidiol (CBD) is the most abundant non-psychoactive phytocannabinoid in C. sativa, and there is an extensive bibliography on its mechanisms of action in the body and its effects on neuropsychiatric disorders, such as anxiety and obsessive-compulsive disorder. In clinical studies with CBD, most have identified therapeutic effects at high doses and have been conducted with intraperitone…
Cannabidiol is the main non-psychotomimetic constituent of the Cannabis sativa plant and has broad therapeutic potential for neuropsychiatric disorders, including anxiety and depression. However, the mechanisms involved in these effects have not been fully elucidated yet. In vitro results suggest that, among the different mechanisms described, CBD is capable of inhibiting adenosine uptake…
(Only some records are available in English at this moment)
Cannabidiol (CBD), a non-psychotomimetic constituent of Cannabis sativa, has been shown to have various therapeutical effects on neuropsychiatric disorders, including anxiety and depression. However, the molecular mechanisms responsible for these effects have not been fully elucidated. These disorders are associated with alterations in the endocannabinoid system (ECS), which comprises can…
Schizophrenia is a disabling developmental psychiatry disorder that involves alterations in the connectivity between various brain regions. The medial prefrontal cortex (mPFC) and amygdala have reciprocal connections that control their activities. A dysregulation in the connectivity between these brain areas is proposed to play a role in the pathophysiology of SCZ. Abnormalities in neurod…
More than 350 million people worldwide are affected by major depressive disorder (DM), which makes it one of the most prevalent mental illnesses. According to the WHO (World Health Organization, 2017). Brazil is a country with the highest incidence of anxiety and depression in the world and MD will be the second leading cause of disability worldwide. Despite many advances in understanding…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 14 / 8 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 47 / 22 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 73 / 42 | All research grants and scholarships |
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