CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Centro de Biologia Molecular e Engenharia Genética (CBMEG) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Dr. Melo is graduated in Biological Sciences from the University of Campinas (1990), Master and PhD in Biological Sciences from the University of Campinas in 1994 and 1998, respectively. During her PhD, she was a fellow at the Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA. From 2001 to 2007 she was professor at the Faculty of Medical Sciences, Santa Casa de São Paulo and is currently a researcher at the Center of Molecular Biology and Genetic Engineering (CBMEG - UNICAMP). Dr. Melo has research experience in the area of Human and Medical Genetics, specially on the following themes: genetics in hematology and ophthalmology. (Source: Lattes Curriculum)
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The term sickle cell disease (SCD) is used to characterize a group of hemoglobinopathies that have a point mutation in the seventh codon of the beta-globin gene in common, located on chromosome 11p15.5.7. Ophthalmological complications are common in sickle cell diseases, including conjunctiva abnormalities, orbital infarctions, retinopathy, and retinal hemorrhage. Retinal alterations are …
The proposed Thematic Project "Pathophysiological Mechanisms and Treatment of Red Blood Cell Abnormalities" will be developed by the Red Blood Cell Research Group at the Hematology Center, the Department of Clinical Pathology and the Center for Molecular Biology and Genetic Engineering (CBMEG), UNICAMP, in collaboration with various Brazilian and international researchers. The project aim…
The purpose of this project is to manage the portion of the Technical Reserve for Institutional Infrastructure Costs for Research for the Year 2020, aiming at improving the common use infrastructure of CBMEG, as well as performing equipment maintenance. (AU)
Glaucoma is the leading cause of irreversible blindness worldwide, affecting about 70 million people, with at least 6.8 million people showing bilateral blindness. Increased intraocular pressure (IOP) is the main risk factor for primary open-angle glaucoma (POAG), in addition to other factors that include increased age, black race, and family aggregation. POAG follows a pattern of complex…
This new Multi-PI thematic project proposal will be conducted by the Red Blood Cell Research Group, which is formed by researchers from the Hemocentro (Blood Center), the Department of Clinical Pathology, School of Medical Sciences and the Molecular Biology and Genetic Engineering Center (CBMEG) at UNICAMP, in collaboration with several Brazilian and international researchers. The new pro…
(Only some records are available in English at this moment)
Glaucoma encompasses a group of optic neuropathies characterized by increased cupping of the optic disc, reduction of the retinal ganglion cell layer, and progressive loss of the visual field. Considered the leading cause of irreversible blindness worldwide, numerous research studies are being conducted to better understand the genetic factors associated with the disease. Among these, the…
Sickle cell retinopathy (SCR) is the most significant ophthalmological complication concerning ocular morbidity in sickle cell diseases. This complication occurs due to vaso-occlusion of the ocular microvasculature, resulting from endothelial activation, inflammatory cascades, adhesion, and coagulation. Consequently, neovascularization may occur, potentially leading to vitreous hemorrhage…
Proliferative sickle cell retinopathy (PSCR) is the ophthalmological alteration with the most relevance regarding ocular morbidity in the group of sickle cell diseases. The pathophysiology involves the aggregation of sickle red blood cells, activation of the endothelium, and thromboinflammatory cascades, leading to arteriolar occlusion of the peripheral retina. In proliferative SCR, the r…
(Only some records are available in English at this moment)
Among the ophthalmological complications present in sickle cell disease, retinal changes are the most relevant with regard to ocular morbidity. Proliferative sickle cell retinopathy (PSCR) occurs due to vaso-occlusion of the ocular microvasculature, which may lead to neovascularization in its proliferative form, which eventually unfolds into vitreous hemorrhage and detachment of the retin…
Sickle cell anemia (SCA) is a hemoglobinopathy resulting from a homozygous mutation in the seventh codon of the beta-globin gene. However, there is extensive clinical variability, with systemic involvement. Neurological changes are common, and it has been related to the greater severity of the disease, being fatal in 15% of cases. Transient ischemic accidents, infarctions and cerebral hem…
(Only some records are available in English at this moment)
Proliferative sickle cell retinopathy (PSCR) is the most severe ophthalmological disorder in patients with sickle cell anemia (SCA). The pathophysiology of the disorder includes sickle cell aggregation, endothelial activation, and thromboinflammatory cascades, leading to artery occlusion in the peripheral retina. The resulting ischemia stimulates neovascularization with fragile vessels. T…
Glaucoma is a neurodegenerative disease of multifactorial etiology that includes several eye disorders whose common features are the progressive damage of the optic nerve with vision loss. It is a major cause of irreversible blindness in the world. Primary open angle glaucoma (POAG) is the most common type of the disease, while Juvenile Open Angle Glaucoma (JOAG) is an earlier onset and m…
Although sickle cell anemia (SCA) results from the homozygosity of a single mutation in amino acid 6 of the ²-globin locus, this disease presents high phenotypic heterogeneity, so that different patients may have significantly different clinical outcomes. Vascular occlusion occurs systemically, and transient ischemic attacks, stroke and cerebral hemorrhage affect approximately 25% of pati…
| 2 / 2 | Ongoing grants |
| 7 / 5 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 25 / 16 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 43 / 32 | All research grants and scholarships |
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